Who We Are
The Marinelli Lab at MCW's Biophysics Department explores how cells function at a molecular level, focusing on membrane transport, signaling, and morphological changes. This research relies on state-of-the-art and novel computer simulation methods, rooted in statistical mechanics and machine-learning. Methodological developments constitute an integral part of the lab research agenda and encompass advanced computational approaches to integrate molecular modeling and wet-lab experiments. A hallmark of the lab work, both in understanding mechanisms and developing methods, is its synergistic collaboration with wet-lab researchers. The lab uses this interdisciplinary approach to advance our understanding of proteins and cellular membranes across molecular and supramolecular scales, aiding the discovery of new therapies against diseases.
Purpose
The Marinelli Lab is offering a Postdoctoral Researcher position to develop advanced computational methods for studying biomolecular systems. The role involves designing innovative machine learning techniques to integrate molecular simulations with experimental data, such as DEER, HDX-MS, NMR, and EM, and may include advancing enhanced sampling and analysis techniques. The successful candidate will have the opportunity to apply these methods to investigate mechanisms of membrane proteins and their interactions with the lipid bilayer, particularly in the contexts of infectious diseases, drug resistance, and cancer.
The role includes contributing to the execution and design of research projects in this area, collaborate with experimental partners, analyze data, present findings at scientific meetings, and prepare manuscripts for peer-reviewed publication.
The lab is committed to providing a rich learning experience while supporting professional growth and transition to career independence.
The position offers a competitive compensation salary aligned with National Institutes of Health (NIH) standards, along with healthcare and other benefits.
Resources
Lab members have access to both dedicated and shared high-performance computing resources, including advanced GPU servers reserved for the lab, through the MCW Research Computing Center.
Characteristics of a Postdoctoral Appointment
It is expected that postdocs at MCW, with the assistance of their supervisor, will:
- Transition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.
- Be supervised by at least one senior scholar who actively promotes the postdoc's professional development.
- Establish an individual development plan (IDP) that incorporates equally the postdoc's career and training goals and the mentor's research goals.
- Pursue basic, clinical, or translational projects so long as effort is focused primarily on research.
- Publish results of the postdoc's research and scholarship during their appointment.
The postdoctoral appointment is temporary by nature, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).
As postdocs are important members of the host institution's community, appropriate levels of compensation, health care, and other benefits commensurate with their essential status should be afforded, independent of the postdoc's source of funding.
Primary Functions
- Plan, design and execute complex research studies, procedures and protocols.
- Participate in discovery projects.
- Coordinate research study activities; lead and manage projects.
- Oversee organization, synthesis and analysis of data and findings.
- Prepare scientific reports, outcome findings and scientific manuscripts.
- Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures.
- Maintain supplies, may require negotiation with vendors, and track purchase orders.
- May oversee the work of laboratory personnel including training and development as well as daily work direction, delegation and establishing priorities.
Knowledge – Skills – Abilities
Required knowledge: biology, chemistry, mathematics, statistics, documentation, records management, data utilization, complex problem solving, critical thinking, resource management, and writing skills
Skills and abilities: This will vary based on the hiring manager’s preferences and should include things that can be learned or trained for.
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