Dr. Hyde. The Institute of Biophysics received department status in 2003, under the leadership of Balaraman Kalyanaraman, PhD.
The Department of Biophysics occupies approximately 20,000 gross square feet on the second floor of the MACC Fund Research Center at the Medical College of Wisconsin. The space includes chemical, biochemical, and two tissue culture labs; an engineering complex; a microwave lab; six EPR spectroscopy labs; a machine shop; a lab for MRI and MRS (magnetic resonance spectroscopy) coil fabrication; and office space and preparation areas. Attached is a high-field magnetic resonance facility managed by the Center for Imaging Research.
The research interests of our faculty are broadly based, with strong programs in the following areas:
- Free radicals and mitochondria, cancer bioenergetics, neuroprotective drugs; metallo antitumor agents; adducts and dynamics of copper complexes; EPR of mixed-valence centers in proteins
- Site-directed spin labeling EPR spectroscopy of peptide–protein interactions, membrane protein structure and dynamics
- Biological chemistry of nitric oxide and related species in physiology and pathology; oxidative biology of sickle cell disease
- EPR instrumentation; functional MRI, functional connectivity MRI at high spatial resolution
- Protein structure and functional dynamics studies using site-directed spin labeling EPR spectroscopy
- Molecular mechanisms of protein function, particularly with respect to the functional role of protein conformational heterogeneity
- MRI and data analysis to measure brain function and structural network organizations
- Spin label studies on membrane dynamics and organization; spin label oximetry
- Cell-specific redox mechanisms disrupting normal cellular homeostasis
- Methods of detection of reactive oxygen and nitrogen species, development of new inhibitors of NADPH oxidases and other enzymes for cardioprotection, neuroprotection, and cancer treatment