Ophthalmology and Visual Sciences

Vision Research at the Eye Institute is organized according to our four Core Modules: Biochemistry/Molecular Biology, Morphology & Microscopic Imaging, Noninvasive Assessment of Animal Modules, and Engineering & Translational Imaging. Our Adaptive Optics Imaging Program (AOIP), Ocular Gene Therapy (OGT) Laboratory, transgenic mouse and rat facility and zebrafish vivarium are just a few of our featured technologies.

Biochemistry - Molecular Biology Transgenic and gene knockout zebrafish technologies Proteomics/Mass spectrometry Precision CRISPR/Cas9 gene editing (rat, zebrafish, human, iPSCs) Mouse and rat transgenic facility
Noninvasive Assessment of Animal Models Imaging of small and large animal models Expertise in zebrafish, ground squirrel, mini swine, rats and mice. Bruker 9.4T MRI Dedicated to small animals
Engineering and Translational Imaging Clinical devices OCT, OCT angiography, fundus imaging, ERG/VEP, microperimetry, visual fields Three adaptive optics imaging systems Enables noninvasive imaging of the living human retina, with sufficient resolution to resolve individual rod and cone photoreceptors
Morphology and Microscopic Imaging Electron microscopy Complete tissue processing facilities Immunoelectron microscopy Negative staining Enzyme cytochemistry Ultrastructural electron tomography Confocal microscopy Multichannel, high-resolution acquisition of fluorescent structures Antibody detection of native proteins Fixed and live cell imaging Super resolution microscope Structured illumination microscopy