Ophthalmology and Visual Sciences

Recent Publications

• Photobiomodulation preserves mitochondrial redox state and is retinoprotective in a rodent model of retinitis pigmentosa.

  (Gopalakrishnan S, Mehrvar S, Maleki S, Schmitt H, Summerfelt P, Dubis AM, Abroe B, Connor TB Jr, Carroll J, Huddleston W, Ranji M, Eells JT.) Sci Rep. 2020 11 23;10(1):20382 PMID: 33230161 PMCID: PMC7684292 SCOPUS ID: 2-s2.0-85096441946 11/25/2020

• Promises and pitfalls of evaluating retinal diseases with adaptive optics scanning light ophthalmoscopy (AOSLO).

  (Wynne N, Carroll J, Duncan JL.) Prog Retin Eye Res. 2020 Nov 05:100920 PMID: 33161127 11/09/2020

• Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation.

  (Szpernal J, Carroll J, Spellecy R, Bachman Groth JA.) J Empir Res Hum Res Ethics. 2020 Nov 02:1556264620968989 PMID: 33135560 SCOPUS ID: 2-s2.0-85094978504 11/03/2020

• Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics.

  (Kraker JA, Omoba BS, Cava JA, Gilat Schmidt T, Chui TY, Rosen RB, Kim JE, Carroll J, Linderman RE.) Transl Vis Sci Technol. 2020 10;9(11):7 PMID: 33101784 PMCID: PMC7545061 10/27/2020

• Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome.

  (Ferre-Fernández JJ, Sorokina EA, Thompson S, Collery RF, Nordquist E, Lincoln J, Semina EV.) Hum Mol Genet. 2020 Sep 29;29(16):2723-2735 PMID: 32720677 PMCID: PMC7530528 SCOPUS ID: 2-s2.0-85092681312 07/29/2020

• Seeking clarity on retinal findings in patients with COVID-19.

  (Collison FT, Carroll J.) Lancet. 2020 09 19;396(10254):e38 PMID: 32950100 PMCID: PMC7498232 SCOPUS ID: 2-s2.0-85090929857 09/21/2020

• Noninvasive Imaging of Cone Ablation and Regeneration in Zebrafish.

  (Huckenpahler AL, Lookfong NA, Warr E, Heffernan E, Carroll J, Collery RF.) Transl Vis Sci Technol. 2020 09;9(10):18 PMID: 32983626 PMCID: PMC7500127 SCOPUS ID: 2-s2.0-85091664660 09/29/2020

• Long-Term Investigation of Retinal Function in Patients with Achromatopsia.

  (Georgiou M, Singh N, Kane T, Zaman S, Hirji N, Aboshiha J, Kumaran N, Kalitzeos A, Carroll J, Weleber RG, Michaelides M.) Invest Ophthalmol Vis Sci. 2020 Sep 01;61(11):38 PMID: 32960951 PMCID: PMC7509756 SCOPUS ID: 2-s2.0-85091579976 09/23/2020

• On the axial location of Gunn's dots.

  (Hammer DX, Liu Z, Cava JA, Carroll J, Saeedi O.) Am J Ophthalmol Case Rep. 2020 Sep;19:100757 PMID: 32551400 PMCID: PMC7287238 06/20/2020

• Preservation of the Foveal Avascular Zone in Achromatopsia Despite the Absence of a Fully Formed Pit.

  (Linderman RE, Georgiou M, Woertz EN, Cava JA, Litts KM, Tarima S, Rajendram R, Provis JM, Michaelides M, Carroll J.) Invest Ophthalmol Vis Sci. 2020 08 03;61(10):52 PMID: 32866266 PMCID: PMC7463179 SCOPUS ID: 2-s2.0-85090108455 09/01/2020

• Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT.

  (Castanos MV, Zhou DB, Linderman RE, Allison R, Milman T, Carroll J, Migacz J, Rosen RB, Chui TYP.) Invest Ophthalmol Vis Sci. 2020 06 03;61(6):48 PMID: 32574351 PMCID: PMC7416910 SCOPUS ID: 2-s2.0-85086976580 06/24/2020

• Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat.

  (Zhang H, Sajdak BS, Merriman DK, McCall MA, Carroll J, Lipinski DM.) Invest Ophthalmol Vis Sci. 2020 06 03;61(6):6 PMID: 32492111 PMCID: PMC7415905 SCOPUS ID: 2-s2.0-85085963234 06/04/2020

• Intraobserver Repeatability and Interobserver Reproducibility of Foveal Cone Density Measurements in CNGA3- and CNGB3-Associated Achromatopsia.

  (Georgiou M, Litts KM, Singh N, Kane T, Patterson EJ, Hirji N, Kalitzeos A, Dubra A, Michaelides M, Carroll J.) Transl Vis Sci Technol. 2020 06;9(7):37 PMID: 32832242 PMCID: PMC7414701 SCOPUS ID: 2-s2.0-85090673745 08/25/2020

• Validating a low-cost laser speckle contrast imaging system as a quantitative tool for assessing retinal vascular function.

  (Patel DD, Lipinski DM.) Sci Rep. 2020 04 28;10(1):7177 PMID: 32346043 PMCID: PMC7188677 04/30/2020

• Quantitative proteomic analysis of aqueous humor after rabbit lensectomy reveals differences in coagulation and immunomodulatory proteins.

  (Young JB, Keppel TR, Waas M, Salmon AE, Buchberger AR, Skumatz CMB, Gundry RL, Kassem IS.) Mol Omics. 2020 04 01;16(2):126-137 PMID: 32031200 SCOPUS ID: 2-s2.0-85083358728 02/08/2020

• Longitudinal Assessment of Remnant Foveal Cone Structure in a Case Series of Early Macular Telangiectasia Type 2.

  (Litts KM, Okada M, Heeren TFC, Kalitzeos A, Rocco V, Mastey RR, Singh N, Kane T, Kasilian M, Fruttiger M, Michaelides M, Carroll J, Egan C.) Transl Vis Sci Technol. 2020 03;9(4):27 PMID: 32818114 PMCID: PMC7396184 08/21/2020

• Zone of retinal vascularization and refractive error in premature eyes with and without spontaneously regressed retinopathy of prematurity.

  (Dikopf MS, Machen LA, Hallak JA, Chau FY, Kassem IS.) J AAPOS. 2019 08;23(4):211.e1-211.e6 PMID: 31229607 PMCID: PMC6778011 SCOPUS ID: 2-s2.0-85070210736 06/24/2019

• Managing a Slipped Muscle Following an Adjustable Suture Medial Rectus Recession.

  (Dotan G, Kassem I, Weaver D, Wagner RS.) J Pediatr Ophthalmol Strabismus. 2019 07 01;56(4):209-211 PMID: 31322707 SCOPUS ID: 2-s2.0-85070099756 07/20/2019

• Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease.

  (Miller JJ, Aoki K, Reid CA, Tiemeyer M, Dahms NM, Kassem IS.) Sci Rep. 2019 06 28;9(1):9392 PMID: 31253878 PMCID: PMC6599056 SCOPUS ID: 2-s2.0-85068107461 06/30/2019

• Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1.

  (Hasan N, Pangeni G, Cobb CA, Ray TA, Nettesheim ER, Ertel KJ, Lipinski DM, McCall MA, Gregg RG.) Cell Rep. 2019 06 11;27(11):3107-3116.e3 PMID: 31189098 PMCID: PMC6628893 06/13/2019

• Sustained Anti-Vascular Endothelial Growth Factor Activity of Aflibercept (Eylea) After Storage in Polycarbonate Syringes Used for Intravitreal Injection: A Pathway to Safety and Efficiency.

  (Han DP, Skumatz C, Besharse JC, Kassem IS.) J Ocul Pharmacol Ther. 2019 06;35(5):278-282 PMID: 30916605 PMCID: PMC6588124 SCOPUS ID: 2-s2.0-85067020226 03/28/2019

• Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

  (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA.) Am J Pathol. 2019 02;189(2):320-338 PMID: 30472209 PMCID: PMC6412726 SCOPUS ID: 2-s2.0-85060099082 11/26/2018

• Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein.

  (Collery RF, Link BA.) Front Cell Dev Biol. 2019;7:167 PMID: 31457013 PMCID: PMC6700241 SCOPUS ID: 2-s2.0-85072723134 08/29/2019

• Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

  (Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM.) PLoS Genet. 2019 01;15(1):e1007939 PMID: 30695061 PMCID: PMC6368336 SCOPUS ID: 2-s2.0-85061272556 01/30/2019

• Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy.

  (Bogaard JD, Young JB, Movahedan A, Kassem IS.) Transl Vis Sci Technol. 2019 Jan;8(1):5 PMID: 30637175 PMCID: PMC6327344 01/15/2019

• A Comparison of Inducible Gene Expression Platforms: Implications for Recombinant Adeno-Associated Virus (rAAV) Vector-Mediated Ocular Gene Therapy.

  (Lipinski DM.) Adv Exp Med Biol. 2019;1185:79-83 PMID: 31884592 12/31/2019

• A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy.

  (Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD.) Invest Ophthalmol Vis Sci. 2018 10 01;59(12):4909-4920 PMID: 30347085 PMCID: PMC6181441 10/23/2018

• Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD.

  (Reid CA, Nettesheim ER, Connor TB, Lipinski DM.) Sci Rep. 2018 08 06;8(1):11763 PMID: 30082848 PMCID: PMC6079038 SCOPUS ID: 2-s2.0-85051247613 08/08/2018

• Findings in Persistent Retinopathy of Prematurity.

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surg Lasers Imaging Retina. 2018 07 01;49(7):497-503 PMID: 30021036 PMCID: PMC6196355 SCOPUS ID: 2-s2.0-85050358307 07/19/2018

• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.

  (Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC.) Transl Vis Sci Technol. 2018;7(5):4 PMID: 30197836 PMCID: PMC6126953 09/11/2018

• Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

  (Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.) Adv Exp Med Biol. 2018;1074:465-471 PMID: 29721977 SCOPUS ID: 2-s2.0-85046643012 05/04/2018

• Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina.

  (Huckenpahler A, Wilk M, Link B, Carroll J, Collery R.) Adv Exp Med Biol. 2018;1074:151-156 PMID: 29721939 PMCID: PMC6363109 SCOPUS ID: 2-s2.0-85046645800 05/04/2018

• Findings in Persistent Retinopathy of Prematurity

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surgery, Lasers, and Imaging Retina.. 05/09/2018

• Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications.

  (Reid CA, Lipinski DM.) Methods Mol Biol. 2018;1715:19-31 PMID: 29188503 12/01/2017

• Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.

  (Reid CA, Ertel KJ, Lipinski DM.) Invest Ophthalmol Vis Sci. 2017 12 01;58(14):6429-6439 PMID: 29260200 PMCID: PMC5736327 12/21/2017

• miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity.

  (Reid CA, Boye SL, Hauswirth WW, Lipinski DM.) Gene Ther. 2017 08;24(8):462-469 PMID: 28617420 06/16/2017

• Biometry Characteristics in Adults and Children With Marfan Syndrome: From the Marfan Eye Consortium of Chicago.

  (Kinori M, Wehrli S, Kassem IS, Azar NF, Maumenee IH, Mets MB.) Am J Ophthalmol. 2017 May;177:144-149 PMID: 28257833 PMCID: PMC5648325 SCOPUS ID: 2-s2.0-85015385280 03/05/2017

• The Effect of Retinal Melanin on Optical Coherence Tomography Images.

  (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J.) Transl Vis Sci Technol. 2017 Apr;6(2):8 PMID: 28392975 PMCID: PMC5381330 04/11/2017

• Imaging the adult zebrafish cone mosaic using optical coherence tomography-CORRIGENDUM.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2017 01;34:E005 PMID: 28965523 SCOPUS ID: 2-s2.0-85057402023 10/03/2017

• Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.

  (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC.) Invest Ophthalmol Vis Sci. 2016 12 01;57(15):6805-6814 PMID: 28002843 PMCID: PMC5215506 SCOPUS ID: 2-s2.0-85007349845 12/22/2016

• Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

  (De Silva SR, Charbel Issa P, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE.) Gene Ther. 2016 11;23(11):767-774 PMID: 27416076 PMCID: PMC5097463 11/04/2016

• Engineering a Light-Attenuating Artificial Iris.

  (Shareef FJ, Sun S, Kotecha M, Kassem I, Azar D, Cho M.) Invest Ophthalmol Vis Sci. 2016 Apr 01;57(4):2195-202 PMID: 27116547 PMCID: PMC4849870 SCOPUS ID: 2-s2.0-84964770541 04/27/2016

• Imaging the adult zebrafish cone mosaic using optical coherence tomography.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2016 01;33:E011 PMID: 28177275 PMCID: PMC5659228 SCOPUS ID: 2-s2.0-85020503535 02/09/2017

• A Case Report of Ablepharon-Macrostomia Syndrome with Amniotic Membrane Grafting.

  (Feinstein E, Traish AS, Aakalu V, Kassem IS.) Case Rep Ophthalmol. 2015 Sep-Dec;6(3):366-72 PMID: 26600791 PMCID: PMC4649710 11/26/2015

• Zebrafish Models of Retinal Disease.

  (Link BA, Collery RF.) Annu Rev Vis Sci. 2015 Nov 24;1:125-153 PMID: 28532376 11/24/2015

• Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection.

  (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW.) Hum Gene Ther. 2015 Nov;26(11):767-76 PMID: 26359319 PMCID: PMC4651034 09/12/2015