Ophthalmology and Visual Sciences

Recent Publications

• Pathognomonic macular ripples are revealed by polarized infrared retinal imaging.

  (Ansari D, Borkar PP, Davis PL, Collison FT, Wynne N, Zangler N, Fishman GA, Carroll J, Yao X, Grassi MA.) Exp Biol Med (Maywood). 2021 Jul 07:15353702211021089 PMID: 34233520 SCOPUS ID: 2-s2.0-85109410596 07/09/2021

• Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO).

  (Wynne N, Carroll J, Duncan JL.) Prog Retin Eye Res. 2021 Jul;83:100920 PMID: 33161127 SCOPUS ID: 2-s2.0-85101352648 11/09/2020

• Optical Coherence Tomography Angiography in the Thirteen-Lined Ground Squirrel.

  (Salmon AE, Chen RC, Atry F, Gaffney M, Merriman DK, Gil DA, Skala MC, Collery R, Allen KP, Buckland E, Pashaie R, Carroll J.) Transl Vis Sci Technol. 2021 07 01;10(8):5 PMID: 34232271 PMCID: PMC8267221 07/08/2021

• Aberrant visual population receptive fields in human albinism.

  (Duwell EJ, Woertz EN, Mathis J, Carroll J, DeYoe EA.) J Vis. 2021 May 03;21(5):19 PMID: 34007988 PMCID: PMC8142699 SCOPUS ID: 2-s2.0-85106168104 05/20/2021

• Comparison of confocal and non-confocal split-detection cone photoreceptor imaging.

  (Sredar N, Razeen M, Kowalski B, Carroll J, Dubra A.) Biomed Opt Express. 2021 Feb 01;12(2):737-755 PMID: 33680539 PMCID: PMC7901313 03/09/2021

• Retinal alterations in patients with Lafora disease

  (Heitkotter H, Linderman RE, Cava JA, Woertz EN, Mastey RR, Summerfelt P, Chui TY, Rosen RB, Patterson EJ, Vincent A, Carroll J, Minassian BA.) American Journal of Ophthalmology Case Reports. September 2021;23 SCOPUS ID: 2-s2.0-85108265763 09/01/2021

• Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy

  (Salmon AE, Cooper RF, Chen M, Higgins B, Cava JA, Chen N, Follett HM, Gaffney M, Heitkotter H, Heffernan E, Schmidt TG, Carroll J.) Biomedical Optics Express. 1 June 2021;12(6):3142-3168 SCOPUS ID: 2-s2.0-85106351305 06/01/2021

• Color vision.

  (Carroll J, Conway BR.) Handb Clin Neurol. 2021;178:131-153 PMID: 33832674 SCOPUS ID: 2-s2.0-85103712796 04/10/2021

• Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia.

  (Litts KM, Woertz EN, Georgiou M, Patterson EJ, Lam BL, Fishman GA, Pennesi ME, Kay CN, Hauswirth WW, Michaelides M, Carroll J.) Transl Vis Sci Technol. 2021 01;10(1):11 PMID: 33510950 PMCID: PMC7804582 SCOPUS ID: 2-s2.0-85099829771 01/30/2021

• Comparison of confocal and non-confocal split-detection cone photoreceptor imaging

  (Sredar N, Razeen M, Kowalski B, Carroll J, Dubra A.) Biomedical Optics Express. 2021;12(2):737-755 SCOPUS ID: 2-s2.0-85100294082 01/01/2021

• Examining whether aoslo-based foveal cone metrics in achromatopsia and albinism are representative of foveal cone structure

  (Litts KM, Woertz EN, Wynne N, Brooks BP, Chacon A, Connor TB, Costakos D, Dumitrescu A, Drack AV, Fishman GA, Hauswirth WW, Kay CN, Lam BL, Michaelides M, Pennesi ME, Stepien KE, Strul S, Summers CG, Carroll J.) Translational Vision Science and Technology. 2021;10(6) SCOPUS ID: 2-s2.0-85106940811 01/01/2021

• Assessing Interocular Symmetry of the Foveal Cone Mosaic.

  (Cava JA, Allphin MT, Mastey RR, Gaffney M, Linderman RE, Cooper RF, Carroll J.) Invest Ophthalmol Vis Sci. 2020 12 01;61(14):23 PMID: 33331861 PMCID: PMC7746960 SCOPUS ID: 2-s2.0-85098742066 12/18/2020

• Photobiomodulation preserves mitochondrial redox state and is retinoprotective in a rodent model of retinitis pigmentosa.

  (Gopalakrishnan S, Mehrvar S, Maleki S, Schmitt H, Summerfelt P, Dubis AM, Abroe B, Connor TB Jr, Carroll J, Huddleston W, Ranji M, Eells JT.) Sci Rep. 2020 11 23;10(1):20382 PMID: 33230161 PMCID: PMC7684292 SCOPUS ID: 2-s2.0-85096441946 11/25/2020

• Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome.

  (Ferre-Fernández JJ, Sorokina EA, Thompson S, Collery RF, Nordquist E, Lincoln J, Semina EV.) Hum Mol Genet. 2020 09 29;29(16):2723-2735 PMID: 32720677 PMCID: PMC7530528 SCOPUS ID: 2-s2.0-85092681312 07/29/2020

• Noninvasive Imaging of Cone Ablation and Regeneration in Zebrafish.

  (Huckenpahler AL, Lookfong NA, Warr E, Heffernan E, Carroll J, Collery RF.) Transl Vis Sci Technol. 2020 09;9(10):18 PMID: 32983626 PMCID: PMC7500127 SCOPUS ID: 2-s2.0-85091664660 09/29/2020

• Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat.

  (Zhang H, Sajdak BS, Merriman DK, McCall MA, Carroll J, Lipinski DM.) Invest Ophthalmol Vis Sci. 2020 06 03;61(6):6 PMID: 32492111 PMCID: PMC7415905 SCOPUS ID: 2-s2.0-85085963234 06/04/2020

• Validating a low-cost laser speckle contrast imaging system as a quantitative tool for assessing retinal vascular function.

  (Patel DD, Lipinski DM.) Sci Rep. 2020 04 28;10(1):7177 PMID: 32346043 PMCID: PMC7188677 04/30/2020

• Quantitative proteomic analysis of aqueous humor after rabbit lensectomy reveals differences in coagulation and immunomodulatory proteins.

  (Young JB, Keppel TR, Waas M, Salmon AE, Buchberger AR, Skumatz CMB, Gundry RL, Kassem IS.) Mol Omics. 2020 04 01;16(2):126-137 PMID: 32031200 SCOPUS ID: 2-s2.0-85083358728 02/08/2020

• Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis.

  (Clark BS, Miesfeld JB, Flinn MA, Collery RF, Link BA.) Front Cell Dev Biol. 2020;8:608112 PMID: 33634099 PMCID: PMC7900515 SCOPUS ID: 2-s2.0-85101223534 02/27/2021

• Zone of retinal vascularization and refractive error in premature eyes with and without spontaneously regressed retinopathy of prematurity.

  (Dikopf MS, Machen LA, Hallak JA, Chau FY, Kassem IS.) J AAPOS. 2019 08;23(4):211.e1-211.e6 PMID: 31229607 PMCID: PMC6778011 SCOPUS ID: 2-s2.0-85070210736 06/24/2019

• Managing a Slipped Muscle Following an Adjustable Suture Medial Rectus Recession.

  (Dotan G, Kassem I, Weaver D, Wagner RS.) J Pediatr Ophthalmol Strabismus. 2019 07 01;56(4):209-211 PMID: 31322707 SCOPUS ID: 2-s2.0-85070099756 07/20/2019

• Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease.

  (Miller JJ, Aoki K, Reid CA, Tiemeyer M, Dahms NM, Kassem IS.) Sci Rep. 2019 06 28;9(1):9392 PMID: 31253878 PMCID: PMC6599056 SCOPUS ID: 2-s2.0-85068107461 06/30/2019

• Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1.

  (Hasan N, Pangeni G, Cobb CA, Ray TA, Nettesheim ER, Ertel KJ, Lipinski DM, McCall MA, Gregg RG.) Cell Rep. 2019 06 11;27(11):3107-3116.e3 PMID: 31189098 PMCID: PMC6628893 06/13/2019

• Sustained Anti-Vascular Endothelial Growth Factor Activity of Aflibercept (Eylea) After Storage in Polycarbonate Syringes Used for Intravitreal Injection: A Pathway to Safety and Efficiency.

  (Han DP, Skumatz C, Besharse JC, Kassem IS.) J Ocul Pharmacol Ther. 2019 06;35(5):278-282 PMID: 30916605 PMCID: PMC6588124 SCOPUS ID: 2-s2.0-85067020226 03/28/2019

• Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

  (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA.) Am J Pathol. 2019 02;189(2):320-338 PMID: 30472209 PMCID: PMC6412726 SCOPUS ID: 2-s2.0-85060099082 11/26/2018

• Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein.

  (Collery RF, Link BA.) Front Cell Dev Biol. 2019;7:167 PMID: 31457013 PMCID: PMC6700241 SCOPUS ID: 2-s2.0-85072723134 08/29/2019

• Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

  (Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM.) PLoS Genet. 2019 01;15(1):e1007939 PMID: 30695061 PMCID: PMC6368336 SCOPUS ID: 2-s2.0-85061272556 01/30/2019

• Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy.

  (Bogaard JD, Young JB, Movahedan A, Kassem IS.) Transl Vis Sci Technol. 2019 Jan;8(1):5 PMID: 30637175 PMCID: PMC6327344 01/15/2019

• A Comparison of Inducible Gene Expression Platforms: Implications for Recombinant Adeno-Associated Virus (rAAV) Vector-Mediated Ocular Gene Therapy.

  (Lipinski DM.) Adv Exp Med Biol. 2019;1185:79-83 PMID: 31884592 12/31/2019

• A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy.

  (Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD.) Invest Ophthalmol Vis Sci. 2018 10 01;59(12):4909-4920 PMID: 30347085 PMCID: PMC6181441 10/23/2018

• Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD.

  (Reid CA, Nettesheim ER, Connor TB, Lipinski DM.) Sci Rep. 2018 08 06;8(1):11763 PMID: 30082848 PMCID: PMC6079038 SCOPUS ID: 2-s2.0-85051247613 08/08/2018

• Findings in Persistent Retinopathy of Prematurity.

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surg Lasers Imaging Retina. 2018 07 01;49(7):497-503 PMID: 30021036 PMCID: PMC6196355 SCOPUS ID: 2-s2.0-85050358307 07/19/2018

• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.

  (Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC.) Transl Vis Sci Technol. 2018;7(5):4 PMID: 30197836 PMCID: PMC6126953 09/11/2018

• Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

  (Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.) Adv Exp Med Biol. 2018;1074:465-471 PMID: 29721977 SCOPUS ID: 2-s2.0-85046643012 05/04/2018

• Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina.

  (Huckenpahler A, Wilk M, Link B, Carroll J, Collery R.) Adv Exp Med Biol. 2018;1074:151-156 PMID: 29721939 PMCID: PMC6363109 SCOPUS ID: 2-s2.0-85046645800 05/04/2018

• Findings in Persistent Retinopathy of Prematurity

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surgery, Lasers, and Imaging Retina.. 05/09/2018

• Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications.

  (Reid CA, Lipinski DM.) Methods Mol Biol. 2018;1715:19-31 PMID: 29188503 12/01/2017

• Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.

  (Reid CA, Ertel KJ, Lipinski DM.) Invest Ophthalmol Vis Sci. 2017 12 01;58(14):6429-6439 PMID: 29260200 PMCID: PMC5736327 12/21/2017

• miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity.

  (Reid CA, Boye SL, Hauswirth WW, Lipinski DM.) Gene Ther. 2017 08;24(8):462-469 PMID: 28617420 06/16/2017

• Biometry Characteristics in Adults and Children With Marfan Syndrome: From the Marfan Eye Consortium of Chicago.

  (Kinori M, Wehrli S, Kassem IS, Azar NF, Maumenee IH, Mets MB.) Am J Ophthalmol. 2017 May;177:144-149 PMID: 28257833 PMCID: PMC5648325 SCOPUS ID: 2-s2.0-85015385280 03/05/2017

• The Effect of Retinal Melanin on Optical Coherence Tomography Images.

  (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J.) Transl Vis Sci Technol. 2017 Apr;6(2):8 PMID: 28392975 PMCID: PMC5381330 04/11/2017

• Imaging the adult zebrafish cone mosaic using optical coherence tomography-CORRIGENDUM.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2017 01;34:E005 PMID: 28965523 PMCID: PMC8054337 SCOPUS ID: 2-s2.0-85057402023 10/03/2017

• Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

  (De Silva SR, Charbel Issa P, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE.) Gene Ther. 2016 11;23(11):767-774 PMID: 27416076 PMCID: PMC5097463 11/04/2016

• Engineering a Light-Attenuating Artificial Iris.

  (Shareef FJ, Sun S, Kotecha M, Kassem I, Azar D, Cho M.) Invest Ophthalmol Vis Sci. 2016 Apr 01;57(4):2195-202 PMID: 27116547 PMCID: PMC4849870 SCOPUS ID: 2-s2.0-84964770541 04/27/2016

• Imaging the adult zebrafish cone mosaic using optical coherence tomography.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2016 01;33:E011 PMID: 28177275 PMCID: PMC5659228 SCOPUS ID: 2-s2.0-85020503535 02/09/2017

• A Case Report of Ablepharon-Macrostomia Syndrome with Amniotic Membrane Grafting.

  (Feinstein E, Traish AS, Aakalu V, Kassem IS.) Case Rep Ophthalmol. 2015 Sep-Dec;6(3):366-72 PMID: 26600791 PMCID: PMC4649710 11/26/2015

• Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection.

  (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW.) Hum Gene Ther. 2015 Nov;26(11):767-76 PMID: 26359319 PMCID: PMC4651034 09/12/2015