Ophthalmology and Visual Sciences

Recent Publications

• Kif17 phosphorylation regulates photoreceptor outer segment turnover.

  (Lewis TR, Kundinger SR, Link BA, Insinna C, Besharse JC.) BMC Cell Biol. 2018 Nov 20;19(1):25.

• Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1.

  (Lewis TR, Zareba M, Link BA, Besharse JC.) Mol Biol Cell. 2018 01 15;29(2):180-190.

• Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.

  (Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC.) Dev Biol. 2017 05 15;425(2):176-190.

• Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.

  (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC.) Invest Ophthalmol Vis Sci. 2016 12 01;57(15):6805-6814.

• The Retina and Other Light-sensitive Ocular Clocks.

  (Besharse JC, McMahon DG.) J Biol Rhythms. 2016 06;31(3):223-43.

• Yap and Taz regulate retinal pigment epithelial cell fate.

  (Miesfeld JB, Gestri G, Clark BS, Flinn MA, Poole RJ, Bader JR, Besharse JC, Wilson SW, Link BA.) Development. 2015 Sep 01;142(17):3021-32.

• Subretinal infiltration of monocyte derived cells and complement misregulation in mice with AMD-like pathology.

  (Fogerty J, Besharse JC.) Adv Exp Med Biol. 2014;801:355-63.

• The kinesin superfamily protein KIF17: one protein with many functions.

  (Wong-Riley MT, Besharse JC.) Biomol Concepts. 2012 Jun 01;3(3):267-282.

• Kinesin-2 family motors in the unusual photoreceptor cilium.

  (Malicki J, Besharse JC.) Vision Res. 2012 Dec 15;75:33-6.

• Analysis of KIF17 distal tip trafficking in zebrafish cone photoreceptors.

  (Bader JR, Kusik BW, Besharse JC.) Vision Res. 2012 Dec 15;75:37-43.

• The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light.

  (Scoma HD, Humby M, Yadav G, Zhang Q, Fogerty J, Besharse JC.) PLoS One. 2011;6(9):e25382.

• 174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy.

  (Fogerty J, Besharse JC.) Invest Ophthalmol Vis Sci. 2011 Sep 14;52(10):7256-66.

• Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina.

  (Huckenpahler A, Wilk M, Link B, Carroll J, Collery R.) Adv Exp Med Biol. 2018;1074:151-156.

• A case of congenital retinal macrovessel in an otherwise normal eye.

  (Strampe MR, Wirostko WJ, Carroll J.) Am J Ophthalmol Case Rep. 2017 Dec;8:18-21.

• Photoreceptor disruption and vision loss associated with central serous retinopathy.

  (Sun LW, Carroll J, Lujan BJ.) Am J Ophthalmol Case Rep. 2017 Dec;8:74-77.

• CELLULAR IMAGING OF THE TAPETAL-LIKE REFLEX IN CARRIERS OF RPGR-ASSOCIATED RETINOPATHY.

  (Kalitzeos A, Samra R, Kasilian M, Tee JJL, Strampe M, Langlo C, Webster AR, Dubra A, Carroll J, Michaelides M.) Retina. 2017 Nov 22.

• Adaptive optics imaging of inherited retinal diseases.

  (Georgiou M, Kalitzeos A, Patterson EJ, Dubra A, Carroll J, Michaelides M.) Br J Ophthalmol. 2018 Aug;102(8):1028-1035.

• Foveal Development in Infants Treated with Bevacizumab or Laser Photocoagulation for Retinopathy of Prematurity.

  (Vogel RN, Strampe M, Fagbemi OE, Visotcky A, Tarima S, Carroll J, Costakos DM.) Ophthalmology. 2018 03;125(3):444-452.

• Imaging the adult zebrafish cone mosaic using optical coherence tomography-CORRIGENDUM.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2017 01;34:E005.

• Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.

  (Litts KM, Cooper RF, Duncan JL, Carroll J.) Invest Ophthalmol Vis Sci. 2017 05 01;58(6):BIO255-BIO267.

• Open source software for automatic detection of cone photoreceptors in adaptive optics ophthalmoscopy using convolutional neural networks.

  (Cunefare D, Fang L, Cooper RF, Dubra A, Carroll J, Farsiu S.) Sci Rep. 2017 Jul 26;7(1):6620.

• Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.

  (Tanna P, Kasilian M, Strauss R, Tee J, Kalitzeos A, Tarima S, Visotcky A, Dubra A, Carroll J, Michaelides M.) Invest Ophthalmol Vis Sci. 2017 07 01;58(9):3608-3615.

• Unsupervised identification of cone photoreceptors in non-confocal adaptive optics scanning light ophthalmoscope images.

  (Bergeles C, Dubis AM, Davidson B, Kasilian M, Kalitzeos A, Carroll J, Dubra A, Michaelides M, Ourselin S.) Biomed Opt Express. 2017 Jun 01;8(6):3081-3094.

• INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY.

  (Strampe MR, Kaehr MM, Carroll J, Kim JE.) Retin Cases Brief Rep. 2017 Jun 19.

• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.

  (Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC.) Transl Vis Sci Technol. 2018;7(5):4.

• Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

  (Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.) Adv Exp Med Biol. 2018;1074:465-471.

• The Effect of Retinal Melanin on Optical Coherence Tomography Images.

  (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J.) Transl Vis Sci Technol. 2017 Apr;6(2):8.

• Imaging the adult zebrafish cone mosaic using optical coherence tomography.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2016 01;33:E011.

• Zebrafish Models of Retinal Disease.

  (Link BA, Collery RF.) Annu Rev Vis Sci. 2015 Nov 24;1:125-153.

• Rapid, accurate, and non-invasive measurement of zebrafish axial length and other eye dimensions using SD-OCT allows longitudinal analysis of myopia and emmetropization.

  (Collery RF, Veth KN, Dubis AM, Carroll J, Link BA.) PLoS One. 2014;9(10):e110699.

• Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology.

  (Collery RF, Cederlund ML, Kennedy BN.) Exp Eye Res. 2013 Mar;108:120-8.

• JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia.

  (Cayo MA, Cai J, DeLaForest A, Noto FK, Nagaoka M, Clark BS, Collery RF, Si-Tayeb K, Duncan SA.) Hepatology. 2012 Dec;56(6):2163-71.

• Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma.

  (Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA.) PLoS Genet. 2011 Feb;7(2):e1001310.

• Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish.

  (Collery RF, Link BA.) Dev Dyn. 2011 Mar;240(3):712-22.

• Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

  (Yu FPS, Sajdak B, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA.) Am J Pathol. 2018 Nov 23.

• Findings in Persistent Retinopathy of Prematurity.

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surg Lasers Imaging Retina. 2018 Jul 01;49(7):497-503.

• Findings in Persistent Retinopathy of Prematurity

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surgery, Lasers, and Imaging Retina.. .

• Biometry Characteristics in Adults and Children With Marfan Syndrome: From the Marfan Eye Consortium of Chicago.

  (Kinori M, Wehrli S, Kassem IS, Azar NF, Maumenee IH, Mets MB.) Am J Ophthalmol. 2017 May;177:144-149.

• Engineering a Light-Attenuating Artificial Iris.

  (Shareef FJ, Sun S, Kotecha M, Kassem I, Azar D, Cho M.) Invest Ophthalmol Vis Sci. 2016 Apr 01;57(4):2195-202.

• A Case Report of Ablepharon-Macrostomia Syndrome with Amniotic Membrane Grafting.

  (Feinstein E, Traish AS, Aakalu V, Kassem IS.) Case Rep Ophthalmol. 2015 Sep-Dec;6(3):366-72.

• Animal models of benign essential blepharospasm and hemifacial spasm

  (Evinger C, Kassem IS.) . Animal Models of Movement Disorders.

• One Year of Pediatric Ophthalmology and Strabismus Research in Review.

  (Kassem IS, Miller MT, Archer SM.) Asia Pac J Ophthalmol (Phila). 2013 Nov-Dec;2(6):388-400.

• Traumatic eye injuries from collapsible wire laundry hampers.

  (Prickett AL, Salar S, Chow CC, Traish AS, Leiderman YI, Chau FY, Kassem IS.) Pediatrics. 2013 Aug;132(2):e522-5.

• Exotropia in children with high hyperopia.

  (Kassem IS, Rubin SE, Kodsi SR.) J AAPOS. 2012 Oct;16(5):437-40.

• Anterior capsular rupture following blunt ocular injury.

  (Gremida A, Kassem I, Traish A.) Digit J Ophthalmol. 2011;17(4):66-8.

• Marcus Gunn jaw winking with trigemino-oculomotor synkinesis of the inferior division of the oculomotor nerve.

  (Kassem IS, Kodsi SR.) J AAPOS. 2009 Jun;13(3):315-6.

• A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy.

  (Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD.) Invest Ophthalmol Vis Sci. 2018 Oct 01;59(12):4909-4920.

• Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD.

  (Reid CA, Nettesheim ER, Connor TB, Lipinski DM.) Sci Rep. 2018 Aug 06;8(1):11763.

• Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.

  (Reid CA, Ertel KJ, Lipinski DM.) Invest Ophthalmol Vis Sci. 2017 12 01;58(14):6429-6439.

• Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications.

  (Reid CA, Lipinski DM.) Methods Mol Biol. 2018;1715:19-31.

• miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity.

  (Reid CA, Boye SL, Hauswirth WW, Lipinski DM.) Gene Ther. 2017 08;24(8):462-469.

• Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4 mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

  (De Silva SR, Charbel Issa P, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE.) Gene Ther. 2016 11;23(11):767-774.

• Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection.

  (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW.) Hum Gene Ther. 2015 Nov;26(11):767-76.

• CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.

  (Lipinski DM, Barnard AR, Singh MS, Martin C, Lee EJ, Davies WIL, MacLaren RE.) Mol Ther. 2015 Aug;23(8):1308-1319.

• Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors.

  (Lipinski DM, Barnard AR, Charbel Issa P, Singh MS, De Silva SR, Trabalza A, Eleftheriadou I, Ellison SM, Mazarakis ND, MacLaren RE.) Hum Gene Ther. 2014 Jan;25(1):50-62.

• Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo.

  (Tolmachova T, Tolmachov OE, Barnard AR, de Silva SR, Lipinski DM, Walker NJ, Maclaren RE, Seabra MC.) J Mol Med (Berl). 2013 Jul;91(7):825-37.

• Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina.

  (Charbel Issa P, De Silva SR, Lipinski DM, Singh MS, Mouravlev A, You Q, Barnard AR, Hankins MW, During MJ, Maclaren RE.) PLoS One. 2013;8(4):e60361.

• Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.

  (Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE.) Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1101-6.