Ophthalmology and Visual Sciences

Recent Publications

• Foveal avascular zone morphology and parafoveal capillary perfusion in sickle cell retinopathy.

  (Lynch G, Scott AW, Linz MO, Han I, Andrade Romo JS, Linderman RE, Carroll J, Rosen RB, Chui TY.) Br J Ophthalmol. 2020 Apr;104(4):473-479 PMID: 31337609 PMCID: PMC6980907 07/25/2019

• Deep Phenotyping of PDE6C-Associated Achromatopsia.

  (Georgiou M, Robson AG, Singh N, Pontikos N, Kane T, Hirji N, Ripamonti C, Rotsos T, Dubra A, Kalitzeos A, Webster AR, Carroll J, Michaelides M.) Invest Ophthalmol Vis Sci. 2019 12 02;60(15):5112-5123 PMID: 31826238 PMCID: PMC6905659 SCOPUS ID: 2-s2.0-85076396804 12/12/2019

• Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia.

  (Mastey RR, Gaffney M, Litts KM, Langlo CS, Patterson EJ, Strampe MR, Kalitzeos A, Michaelides M, Carroll J.) Transl Vis Sci Technol. 2019 Sep;8(5):21 PMID: 31602346 PMCID: PMC6779097 10/12/2019

• Peripheral nerve pathology in sickle cell disease mice.

  (Sadler KE, Lewis TR, Waltz TB, Besharse JC, Stucky CL.) Pain Rep. 2019 Jul-Aug;4(4):e765 PMID: 31579856 PMCID: PMC6728004 10/04/2019

• RAC-CNN: multimodal deep learning based automatic detection and classification of rod and cone photoreceptors in adaptive optics scanning light ophthalmoscope images.

  (Cunefare D, Huckenpahler AL, Patterson EJ, Dubra A, Carroll J, Farsiu S.) Biomed Opt Express. 2019 Aug 01;10(8):3815-3832 PMID: 31452977 PMCID: PMC6701534 08/28/2019

• Zone of retinal vascularization and refractive error in premature eyes with and without spontaneously regressed retinopathy of prematurity.

  (Dikopf MS, Machen LA, Hallak JA, Chau FY, Kassem IS.) J AAPOS. 2019 Aug;23(4):211.e1-211.e6 PMID: 31229607 PMCID: PMC6778011 SCOPUS ID: 2-s2.0-85070210736 06/24/2019

• Earliest Evidence of Preclinical Diabetic Retinopathy Revealed Using Optical Coherence Tomography Angiography Perfused Capillary Density.

  (Rosen RB, Andrade Romo JS, Krawitz BD, Mo S, Fawzi AA, Linderman RE, Carroll J, Pinhas A, Chui TYP.) Am J Ophthalmol. 2019 07;203:103-115 PMID: 30689991 PMCID: PMC6612596 SCOPUS ID: 2-s2.0-85064828500 01/29/2019

• Managing a Slipped Muscle Following an Adjustable Suture Medial Rectus Recession.

  (Dotan G, Kassem I, Weaver D, Wagner RS.) J Pediatr Ophthalmol Strabismus. 2019 07 01;56(4):209-211 PMID: 31322707 SCOPUS ID: 2-s2.0-85070099756 07/20/2019

• Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease.

  (Miller JJ, Aoki K, Reid CA, Tiemeyer M, Dahms NM, Kassem IS.) Sci Rep. 2019 Jun 28;9(1):9392 PMID: 31253878 PMCID: PMC6599056 SCOPUS ID: 2-s2.0-85068107461 06/30/2019

• PRCD is essential for high-fidelity photoreceptor disc formation.

  (Spencer WJ, Ding JD, Lewis TR, Yu C, Phan S, Pearring JN, Kim KY, Thor A, Mathew R, Kalnitsky J, Hao Y, Travis AM, Biswas SK, Lo WK, Besharse JC, Ellisman MH, Saban DR, Burns ME, Arshavsky VY.) Proc Natl Acad Sci U S A. 2019 06 25;116(26):13087-13096 PMID: 31189593 PMCID: PMC6601265 SCOPUS ID: 2-s2.0-85068112749 06/14/2019

• Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1.

  (Hasan N, Pangeni G, Cobb CA, Ray TA, Nettesheim ER, Ertel KJ, Lipinski DM, McCall MA, Gregg RG.) Cell Rep. 2019 06 11;27(11):3107-3116.e3 PMID: 31189098 PMCID: PMC6628893 06/13/2019

• Characterization of Retinal Structure in ATF6-Associated Achromatopsia.

  (Mastey RR, Georgiou M, Langlo CS, Kalitzeos A, Patterson EJ, Kane T, Singh N, Vincent A, Moore AT, Tsang SH, Lin JH, Young MP, Hartnett ME, Héon E, Kohl S, Michaelides M, Carroll J.) Invest Ophthalmol Vis Sci. 2019 06 03;60(7):2631-2640 PMID: 31237654 PMCID: PMC6594318 SCOPUS ID: 2-s2.0-85068605953 06/27/2019

• Sustained Anti-Vascular Endothelial Growth Factor Activity of Aflibercept (Eylea) After Storage in Polycarbonate Syringes Used for Intravitreal Injection: A Pathway to Safety and Efficiency.

  (Han DP, Skumatz C, Besharse JC, Kassem IS.) J Ocul Pharmacol Ther. 2019 06;35(5):278-282 PMID: 30916605 PMCID: PMC6588124 SCOPUS ID: 2-s2.0-85067020226 03/28/2019

• Evaluating seasonal changes of cone photoreceptor structure in the 13-lined ground squirrel.

  (Sajdak BS, Salmon AE, Litts KM, Wells C, Allen KP, Dubra A, Merriman DK, Carroll J.) Vision Res. 2019 05;158:90-99 PMID: 30826354 PMCID: PMC6538439 SCOPUS ID: 2-s2.0-85062420704 03/04/2019

• Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

  (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA.) Am J Pathol. 2019 02;189(2):320-338 PMID: 30472209 PMCID: PMC6412726 SCOPUS ID: 2-s2.0-85060099082 11/26/2018

• Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel.

  (Sajdak BS, Salmon AE, Linderman RE, Cava JA, Heitkotter H, Carroll J.) PLoS One. 2019;14(9):e0223110 PMID: 31557245 PMCID: PMC6762077 SCOPUS ID: 2-s2.0-85072655047 09/27/2019

• Assessing Retinal Structure in Patients with Parkinson's Disease.

  (Young JB, Godara P, Williams V, Summerfelt P, Connor TB, Tarima S, Visotcky A, Cooper RF, Blindauer K, Carroll J.) J Neurol Neurophysiol. 2019;10(1) PMID: 31057987 PMCID: PMC6494090 05/07/2019

• Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein.

  (Collery RF, Link BA.) Front Cell Dev Biol. 2019;7:167 PMID: 31457013 PMCID: PMC6700241 SCOPUS ID: 2-s2.0-85072723134 08/29/2019

• Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

  (Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM.) PLoS Genet. 2019 01;15(1):e1007939 PMID: 30695061 PMCID: PMC6368336 SCOPUS ID: 2-s2.0-85061272556 01/30/2019

• Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy.

  (Bogaard JD, Young JB, Movahedan A, Kassem IS.) Transl Vis Sci Technol. 2019 Jan;8(1):5 PMID: 30637175 PMCID: PMC6327344 01/15/2019

• A Comparison of Inducible Gene Expression Platforms: Implications for Recombinant Adeno-Associated Virus (rAAV) Vector-Mediated Ocular Gene Therapy.

  (Lipinski DM.) Adv Exp Med Biol. 2019;1185:79-83 PMID: 31884592 12/31/2019

• Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using OCT reflectance and OCT angiography.

  (Lynch G, Romo JSA, Linderman R, Krawitz BD, Mo S, Zakik A, Carroll J, Rosen RB, Chui TYP.) Biomed Opt Express. 2018 Dec 01;9(12):5982-5996 PMID: 31065407 PMCID: PMC6491024 05/09/2019

• Kif17 phosphorylation regulates photoreceptor outer segment turnover.

  (Lewis TR, Kundinger SR, Link BA, Insinna C, Besharse JC.) BMC Cell Biol. 2018 11 20;19(1):25 PMID: 30458707 PMCID: PMC6245759 SCOPUS ID: 2-s2.0-85056802940 11/22/2018

• A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy.

  (Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD.) Invest Ophthalmol Vis Sci. 2018 10 01;59(12):4909-4920 PMID: 30347085 PMCID: PMC6181441 10/23/2018

• Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD.

  (Reid CA, Nettesheim ER, Connor TB, Lipinski DM.) Sci Rep. 2018 08 06;8(1):11763 PMID: 30082848 PMCID: PMC6079038 SCOPUS ID: 2-s2.0-85051247613 08/08/2018

• Findings in Persistent Retinopathy of Prematurity.

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surg Lasers Imaging Retina. 2018 07 01;49(7):497-503 PMID: 30021036 PMCID: PMC6196355 SCOPUS ID: 2-s2.0-85050358307 07/19/2018

• Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1.

  (Lewis TR, Zareba M, Link BA, Besharse JC.) Mol Biol Cell. 2018 01 15;29(2):180-190 PMID: 29142075 PMCID: PMC5909930 SCOPUS ID: 2-s2.0-85040967232 11/17/2017

• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.

  (Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC.) Transl Vis Sci Technol. 2018;7(5):4 PMID: 30197836 PMCID: PMC6126953 09/11/2018

• Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

  (Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.) Adv Exp Med Biol. 2018;1074:465-471 PMID: 29721977 SCOPUS ID: 2-s2.0-85046643012 05/04/2018

• Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina.

  (Huckenpahler A, Wilk M, Link B, Carroll J, Collery R.) Adv Exp Med Biol. 2018;1074:151-156 PMID: 29721939 PMCID: PMC6363109 SCOPUS ID: 2-s2.0-85046645800 05/04/2018

• Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications.

  (Reid CA, Lipinski DM.) Methods Mol Biol. 2018;1715:19-31 PMID: 29188503 12/01/2017

• Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.

  (Reid CA, Ertel KJ, Lipinski DM.) Invest Ophthalmol Vis Sci. 2017 12 01;58(14):6429-6439 PMID: 29260200 PMCID: PMC5736327 12/21/2017

• miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity.

  (Reid CA, Boye SL, Hauswirth WW, Lipinski DM.) Gene Ther. 2017 08;24(8):462-469 PMID: 28617420 06/16/2017

• Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.

  (Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC.) Dev Biol. 2017 05 15;425(2):176-190 PMID: 28341548 PMCID: PMC5558849 SCOPUS ID: 2-s2.0-85016498928 03/28/2017

• Biometry Characteristics in Adults and Children With Marfan Syndrome: From the Marfan Eye Consortium of Chicago.

  (Kinori M, Wehrli S, Kassem IS, Azar NF, Maumenee IH, Mets MB.) Am J Ophthalmol. 2017 May;177:144-149 PMID: 28257833 PMCID: PMC5648325 SCOPUS ID: 2-s2.0-85015385280 03/05/2017

• The Effect of Retinal Melanin on Optical Coherence Tomography Images.

  (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J.) Transl Vis Sci Technol. 2017 Apr;6(2):8 PMID: 28392975 PMCID: PMC5381330 04/11/2017

• Imaging the adult zebrafish cone mosaic using optical coherence tomography-CORRIGENDUM.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2017 01;34:E005 PMID: 28965523 SCOPUS ID: 2-s2.0-85057402023 10/03/2017

• Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.

  (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC.) Invest Ophthalmol Vis Sci. 2016 12 01;57(15):6805-6814 PMID: 28002843 PMCID: PMC5215506 SCOPUS ID: 2-s2.0-85007349845 12/22/2016

• Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4 mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

  (De Silva SR, Charbel Issa P, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE.) Gene Ther. 2016 11;23(11):767-774 PMID: 27416076 PMCID: PMC5097463 11/04/2016

• The Retina and Other Light-sensitive Ocular Clocks.

  (Besharse JC, McMahon DG.) J Biol Rhythms. 2016 06;31(3):223-43 PMID: 27095816 PMCID: PMC5479307 SCOPUS ID: 2-s2.0-84966564991 04/21/2016

• Engineering a Light-Attenuating Artificial Iris.

  (Shareef FJ, Sun S, Kotecha M, Kassem I, Azar D, Cho M.) Invest Ophthalmol Vis Sci. 2016 Apr 01;57(4):2195-202 PMID: 27116547 PMCID: PMC4849870 SCOPUS ID: 2-s2.0-84964770541 04/27/2016

• Imaging the adult zebrafish cone mosaic using optical coherence tomography.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2016 01;33:E011 PMID: 28177275 PMCID: PMC5659228 SCOPUS ID: 2-s2.0-85020503535 02/09/2017

• A Case Report of Ablepharon-Macrostomia Syndrome with Amniotic Membrane Grafting.

  (Feinstein E, Traish AS, Aakalu V, Kassem IS.) Case Rep Ophthalmol. 2015 Sep-Dec;6(3):366-72 PMID: 26600791 PMCID: PMC4649710 11/26/2015

• Zebrafish Models of Retinal Disease.

  (Link BA, Collery RF.) Annu Rev Vis Sci. 2015 Nov 24;1:125-153 PMID: 28532376 11/24/2015

• Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection.

  (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW.) Hum Gene Ther. 2015 Nov;26(11):767-76 PMID: 26359319 PMCID: PMC4651034 09/12/2015

• Yap and Taz regulate retinal pigment epithelial cell fate.

  (Miesfeld JB, Gestri G, Clark BS, Flinn MA, Poole RJ, Bader JR, Besharse JC, Wilson SW, Link BA.) Development. 2015 Sep 01;142(17):3021-32 PMID: 26209646 PMCID: PMC4582179 SCOPUS ID: 2-s2.0-84940754780 07/26/2015

• CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.

  (Lipinski DM, Barnard AR, Singh MS, Martin C, Lee EJ, Davies WIL, MacLaren RE.) Mol Ther. 2015 Aug;23(8):1308-1319 PMID: 25896245 PMCID: PMC4539573 04/22/2015

• Subretinal infiltration of monocyte derived cells and complement misregulation in mice with AMD-like pathology.

  (Fogerty J, Besharse JC.) Adv Exp Med Biol. 2014;801:355-63 PMID: 24664718 PMCID: PMC4273561 SCOPUS ID: 2-s2.0-84904807031 03/26/2014

• Rapid, accurate, and non-invasive measurement of zebrafish axial length and other eye dimensions using SD-OCT allows longitudinal analysis of myopia and emmetropization.

  (Collery RF, Veth KN, Dubis AM, Carroll J, Link BA.) PLoS One. 2014;9(10):e110699 PMID: 25334040 PMCID: PMC4205002 SCOPUS ID: 2-s2.0-84908190382 10/22/2014

• Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation.

  (Zhang L, Ma P, Collery R, Trowbridge S, Zhang M, Zhong W, Leung YF.) Mol Vis. 2014;20:56-72 PMID: 24426776 PMCID: PMC3888495 SCOPUS ID: 2-s2.0-84891769215 01/16/2014

• Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors.

  (Lipinski DM, Barnard AR, Charbel Issa P, Singh MS, De Silva SR, Trabalza A, Eleftheriadou I, Ellison SM, Mazarakis ND, MacLaren RE.) Hum Gene Ther. 2014 Jan;25(1):50-62 PMID: 24125177 10/16/2013

• The kinesin superfamily protein KIF17: one protein with many functions.

  (Wong-Riley MT, Besharse JC.) Biomol Concepts. 2012 Jun 01;3(3):267-282 PMID: 23762210 PMCID: PMC3677786 06/14/2013

• Kif17 phosphorylation regulates its ciliary localization and photoreceptor outer segment turnover.

  (Lewis, TRrnKundinger, SRrnLink, BA rnBesharse, JC.) bioRxiv. bioRxiv 351122; doi: https://doi.org/10.1101/351122 06/20/2018

• Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies: A Systematic Review.

  (Llanas S, Linderman RE, Chen FK, Carroll J.) JAMA Ophthalmol. 2019 Nov 27 PMID: 31774456 SCOPUS ID: 2-s2.0-85075795857 11/28/2019

• RAC-CNN: Multimodal deep learning based automatic detection and classification of rod and cone photoreceptors in adaptive optics scanning light ophthalmoscope images

  (Cunefare D, Huckenpahler AL, Patterson EJ, Dubra A, Carroll J, Farsiu S.) Biomedical Optics Express. 1 August 2019;10(8):3815-3832 SCOPUS ID: 2-s2.0-85070796295 08/01/2019

• Quantitative proteomic analysis of aqueous humor after rabbit lensectomy reveals differences in coagulation and immunomodulatory proteins.

  (Young JB, Keppel TR, Waas M, Salmon AE, Buchberger AR, Skumatz CMB, Gundry RL, Kassem IS.) Mol Omics. 2020 Feb 07 PMID: 32031200 02/08/2020

• Findings in Persistent Retinopathy of Prematurity

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surgery, Lasers, and Imaging Retina.. 05/09/2018