Ophthalmology and Visual Sciences

Recent Publications

• Peripheral nerve pathology in sickle cell disease mice.

  (Sadler KE, Lewis TR, Waltz TB, Besharse JC, Stucky CL.) Pain Rep. 2019 Jul-Aug;4(4):e765.

• Zone of retinal vascularization and refractive error in premature eyes with and without spontaneously regressed retinopathy of prematurity.

  (Dikopf MS, Machen LA, Hallak JA, Chau FY, Kassem IS.) J AAPOS. 2019 Aug;23(4):211.e1-211.e6.

• Foveal avascular zone morphology and parafoveal capillary perfusion in sickle cell retinopathy.

  (Lynch G, Scott AW, Linz MO, Han I, Andrade Romo JS, Linderman RE, Carroll J, Rosen RB, Chui TY.) Br J Ophthalmol. 2019 Jul 23.

• Earliest Evidence of Preclinical Diabetic Retinopathy Revealed Using Optical Coherence Tomography Angiography Perfused Capillary Density.

  (Rosen RB, Andrade Romo JS, Krawitz BD, Mo S, Fawzi AA, Linderman RE, Carroll J, Pinhas A, Chui TYP.) Am J Ophthalmol. 2019 Jul;203:103-115.

• Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease.

  (Miller JJ, Aoki K, Reid CA, Tiemeyer M, Dahms NM, Kassem IS.) Sci Rep. 2019 Jun 28;9(1):9392.

• PRCD is essential for high-fidelity photoreceptor disc formation.

  (Spencer WJ, Ding JD, Lewis TR, Yu C, Phan S, Pearring JN, Kim KY, Thor A, Mathew R, Kalnitsky J, Hao Y, Travis AM, Biswas SK, Lo WK, Besharse JC, Ellisman MH, Saban DR, Burns ME, Arshavsky VY.) Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13087-13096.

• Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1.

  (Hasan N, Pangeni G, Cobb CA, Ray TA, Nettesheim ER, Ertel KJ, Lipinski DM, McCall MA, Gregg RG.) Cell Rep. 2019 Jun 11;27(11):3107-3116.e3.

• Characterization of Retinal Structure in ATF6-Associated Achromatopsia.

  (Mastey RR, Georgiou M, Langlo CS, Kalitzeos A, Patterson EJ, Kane T, Singh N, Vincent A, Moore AT, Tsang SH, Lin JH, Young MP, Hartnett ME, Héon E, Kohl S, Michaelides M, Carroll J.) Invest Ophthalmol Vis Sci. 2019 Jun 03;60(7):2631-2640.

• Sustained Anti-Vascular Endothelial Growth Factor Activity of Aflibercept (Eylea) After Storage in Polycarbonate Syringes Used for Intravitreal Injection: A Pathway to Safety and Efficiency.

  (Han DP, Skumatz C, Besharse JC, Kassem IS.) J Ocul Pharmacol Ther. 2019 Jun;35(5):278-282.

• Evaluating seasonal changes of cone photoreceptor structure in the 13-lined ground squirrel.

  (Sajdak BS, Salmon AE, Litts KM, Wells C, Allen KP, Dubra A, Merriman DK, Carroll J.) Vision Res. 2019 05;158:90-99.

• Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

  (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA.) Am J Pathol. 2019 02;189(2):320-338.

• Adaptive Optics Retinal Imaging in CNGA3-Associated Achromatopsia: Retinal Characterization, Interocular Symmetry, and Intrafamilial Variability.

  (Georgiou M, Litts KM, Kalitzeos A, Langlo CS, Kane T, Singh N, Kassilian M, Hirji N, Kumaran N, Dubra A, Carroll J, Michaelides M.) Invest Ophthalmol Vis Sci. 2019 01 02;60(1):383-396.

• Assessing Retinal Structure in Patients with Parkinson's Disease.

  (Young JB, Godara P, Williams V, Summerfelt P, Connor TB, Tarima S, Visotcky A, Cooper RF, Blindauer K, Carroll J.) J Neurol Neurophysiol. 2019;10(1).

• The Utility of Frame Averaging for Automated Algorithms in Analyzing Retinal Vascular Biomarkers in AngioVue OCTA.

  (Schmidt TG, Linderman RE, Strampe MR, Chui TYP, Rosen RB, Carroll J.) Transl Vis Sci Technol. 2019 Jan;8(1):10.

• Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein.

  (Collery RF, Link BA.) Front Cell Dev Biol. 2019;7:167.

• Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

  (Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM.) PLoS Genet. 2019 01;15(1):e1007939.

• Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy.

  (Bogaard JD, Young JB, Movahedan A, Kassem IS.) Transl Vis Sci Technol. 2019 Jan;8(1):5.

• Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using OCT reflectance and OCT angiography.

  (Lynch G, Romo JSA, Linderman R, Krawitz BD, Mo S, Zakik A, Carroll J, Rosen RB, Chui TYP.) Biomed Opt Express. 2018 Dec 01;9(12):5982-5996.

• Kif17 phosphorylation regulates photoreceptor outer segment turnover.

  (Lewis TR, Kundinger SR, Link BA, Insinna C, Besharse JC.) BMC Cell Biol. 2018 11 20;19(1):25.

• A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy.

  (Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD.) Invest Ophthalmol Vis Sci. 2018 10 01;59(12):4909-4920.

• Fast adaptive optics scanning light ophthalmoscope retinal montaging.

  (Davidson B, Kalitzeos A, Carroll J, Dubra A, Ourselin S, Michaelides M, Bergeles C.) Biomed Opt Express. 2018 Sep 01;9(9):4317-4328.

• Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD.

  (Reid CA, Nettesheim ER, Connor TB, Lipinski DM.) Sci Rep. 2018 08 06;8(1):11763.

• Findings in Persistent Retinopathy of Prematurity.

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surg Lasers Imaging Retina. 2018 07 01;49(7):497-503.

• Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1.

  (Lewis TR, Zareba M, Link BA, Besharse JC.) Mol Biol Cell. 2018 01 15;29(2):180-190.

• Assessing photoreceptor structure in patients with traumatic head injury.

  (Braza ME, Young J, Hammeke TA, Robison SE, Han DP, Warren CC, Carroll J, Stepien KE.) BMJ Open Ophthalmol. 2018;3(1):e000104.

• Imaging retinal melanin: a review of current technologies.

  (Lapierre-Landry M, Carroll J, Skala MC.) J Biol Eng. 2018;12:29.

• Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.

  (Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC.) Transl Vis Sci Technol. 2018;7(5):4.

• Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

  (Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.) Adv Exp Med Biol. 2018;1074:465-471.

• Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina.

  (Huckenpahler A, Wilk M, Link B, Carroll J, Collery R.) Adv Exp Med Biol. 2018;1074:151-156.

• Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications.

  (Reid CA, Lipinski DM.) Methods Mol Biol. 2018;1715:19-31.

• Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.

  (Reid CA, Ertel KJ, Lipinski DM.) Invest Ophthalmol Vis Sci. 2017 12 01;58(14):6429-6439.

• miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity.

  (Reid CA, Boye SL, Hauswirth WW, Lipinski DM.) Gene Ther. 2017 08;24(8):462-469.

• Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.

  (Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC.) Dev Biol. 2017 05 15;425(2):176-190.

• Biometry Characteristics in Adults and Children With Marfan Syndrome: From the Marfan Eye Consortium of Chicago.

  (Kinori M, Wehrli S, Kassem IS, Azar NF, Maumenee IH, Mets MB.) Am J Ophthalmol. 2017 May;177:144-149.

• The Effect of Retinal Melanin on Optical Coherence Tomography Images.

  (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J.) Transl Vis Sci Technol. 2017 Apr;6(2):8.

• Imaging the adult zebrafish cone mosaic using optical coherence tomography-CORRIGENDUM.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2017 01;34:E005.

• Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.

  (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC.) Invest Ophthalmol Vis Sci. 2016 12 01;57(15):6805-6814.

• Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4 mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

  (De Silva SR, Charbel Issa P, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE.) Gene Ther. 2016 11;23(11):767-774.

• The Retina and Other Light-sensitive Ocular Clocks.

  (Besharse JC, McMahon DG.) J Biol Rhythms. 2016 06;31(3):223-43.

• Engineering a Light-Attenuating Artificial Iris.

  (Shareef FJ, Sun S, Kotecha M, Kassem I, Azar D, Cho M.) Invest Ophthalmol Vis Sci. 2016 Apr 01;57(4):2195-202.

• Imaging the adult zebrafish cone mosaic using optical coherence tomography.

  (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2016 01;33:E011.

• A Case Report of Ablepharon-Macrostomia Syndrome with Amniotic Membrane Grafting.

  (Feinstein E, Traish AS, Aakalu V, Kassem IS.) Case Rep Ophthalmol. 2015 Sep-Dec;6(3):366-72.

• Zebrafish Models of Retinal Disease.

  (Link BA, Collery RF.) Annu Rev Vis Sci. 2015 Nov 24;1:125-153.

• Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection.

  (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW.) Hum Gene Ther. 2015 Nov;26(11):767-76.

• Yap and Taz regulate retinal pigment epithelial cell fate.

  (Miesfeld JB, Gestri G, Clark BS, Flinn MA, Poole RJ, Bader JR, Besharse JC, Wilson SW, Link BA.) Development. 2015 Sep 01;142(17):3021-32.

• CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.

  (Lipinski DM, Barnard AR, Singh MS, Martin C, Lee EJ, Davies WIL, MacLaren RE.) Mol Ther. 2015 Aug;23(8):1308-1319.

• Subretinal infiltration of monocyte derived cells and complement misregulation in mice with AMD-like pathology.

  (Fogerty J, Besharse JC.) Adv Exp Med Biol. 2014;801:355-63.

• Rapid, accurate, and non-invasive measurement of zebrafish axial length and other eye dimensions using SD-OCT allows longitudinal analysis of myopia and emmetropization.

  (Collery RF, Veth KN, Dubis AM, Carroll J, Link BA.) PLoS One. 2014;9(10):e110699.

• Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation.

  (Zhang L, Ma P, Collery R, Trowbridge S, Zhang M, Zhong W, Leung YF.) Mol Vis. 2014;20:56-72.

• Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors.

  (Lipinski DM, Barnard AR, Charbel Issa P, Singh MS, De Silva SR, Trabalza A, Eleftheriadou I, Ellison SM, Mazarakis ND, MacLaren RE.) Hum Gene Ther. 2014 Jan;25(1):50-62.

• One Year of Pediatric Ophthalmology and Strabismus Research in Review.

  (Kassem IS, Miller MT, Archer SM.) Asia Pac J Ophthalmol (Phila). 2013 Nov-Dec;2(6):388-400.

• Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo.

  (Tolmachova T, Tolmachov OE, Barnard AR, de Silva SR, Lipinski DM, Walker NJ, Maclaren RE, Seabra MC.) J Mol Med (Berl). 2013 Jul;91(7):825-37.

• The kinesin superfamily protein KIF17: one protein with many functions.

  (Wong-Riley MT, Besharse JC.) Biomol Concepts. 2012 Jun 01;3(3):267-282.

• Kif17 phosphorylation regulates its ciliary localization and photoreceptor outer segment turnover.

  (Lewis, TRrnKundinger, SRrnLink, BA rnBesharse, JC.) bioRxiv. bioRxiv 351122; doi: https://doi.org/10.1101/351122.

• RAC-CNN: Multimodal deep learning based automatic detection and classification of rod and cone photoreceptors in adaptive optics scanning light ophthalmoscope images

  (Cunefare D, Huckenpahler AL, Patterson EJ, Dubra A, Carroll J, Farsiu S.) Biomedical Optics Express. 1 August 2019;10(8):3815-3832.

• Findings in Persistent Retinopathy of Prematurity

  (Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM.) Ophthalmic Surgery, Lasers, and Imaging Retina.. .

• Animal models of benign essential blepharospasm and hemifacial spasm

  (Evinger C, Kassem IS.) . Animal Models of Movement Disorders.