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Research Bench Lab

MCW Mellowes Center Outreach

At the Mellowes Center, we believe that community is fostered by working together to achieve something larger than ourselves. Our dedication goes beyond research; it's about cultivating a generation of passionate scientists while fulfilling our responsibilities as compassionate stewards within our global, regional, and local communities.

Mellowes Center impacts health around the world

Mellowes Center Impacts Health Around the World

Since 2017, the Mellowes Center has significantly expanded its national and international collaborations for rare and undiagnosed disease research and clinical care. By partnering with esteemed researchers and clinicians worldwide, the Center leverages cutting-edge technologies and advanced analytical methodologies to understand each patient’s genome and what it reveals about their health, wellness, discomfort, or disease. These research collaborations enable the Mellowes Center to bring advanced analytics to a broader network of patients with undiagnosed or rare conditions, ultimately striving to improve patient care and health outcomes. Future projects will continue to build on these efforts by enhancing genomic analysis to diagnose and treat rare diseases with precision and by applying the knowledge gathered from a single patient variant to learn more about the thousands affected by the disease.

International Collaborations

INSERM, National Institute of Health and Medical Research | Marseille, France

Dr. Urrutia's collaboration with Dr. Iovanna has led to groundbreaking discoveries in precision medicine, notably the importance of including epigenomic approaches in the classification of pancreatic subtypes (Basal vs. Classical), each requiring unique therapeutic approaches.

PMCID: PMC12304713 - Understanding the heterogeneity of pancreatic ductal adenocarcinoma

PMCID: PMC12143771 - KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

Saint Joan de Deu Children’s Hospital | Barcelona, Spain

Collaborations with Drs. Francesc Palau & Janet Hoenicka help to treat patients that have symptoms but no diagnosis. Using 3D Genomics, we generate models of protein movement and function as well as conduct experiments in patient-derived cell lines to determine how each unique, potentially one-of-a-kind, genetic change affects physiology.

PMCID: PMC11722552 - Abnormal redox balance at membrane contact sites causes axonopathy in GDAP1-related Charcot-Marie-Tooth disease

Casa de Raros | Porto Alegre, Brazil

Dr. Urrutia's collaboration in Brazil offers a unique opportunity to leverage his lab's advanced computational genomics and 3D modeling techniques within their diverse genomic database, establishing an interconnected network of comprehensive care for people with rare diseases. The goal is to provide multidisciplinary care to patients and their families through rapid and accurate diagnosis, advance treatment options, establish research focused on rare genetic diseases, and train the next generation of health professionals.

Casa de Raros Website

National Collaborations

We are proud to collaborate at local, regional, and national levels, reflecting our commitment to advancing discovery through connection. From partnerships rooted in Wisconsin to alliances across the Midwest and coast to coast, we work together to accelerate research, strengthen clinical impact, and engage communities nationwide.

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Alliances Coast to Coast 

Seattle Children’s Hospital | Seattle, WA
To showcase the impactful role of patient narratives in medicine Dr. Urrutia teams up with Dr. Aviya Lanis. These storytelling sessions offer healing to patients and caregivers navigating their diagnostic journey and can lessen the burden of anxiety, depression, and disconnectedness that patients with chronic illnesses often feel. Also, practitioners are reminded of the humanity behind disease and re-invigorated by the primary pursuit, to heal the whole patient.

Nationwide Children's Hospital (NCH) | Columbus, Ohio
The longstanding collaboration with Dr. Roshini Abraham is very effective in investigating inflammatory diseases with inborn errors of immunity. Patient cases are discussed with the intent to understand genetic variants, link these variants to disease diagnosis, and ultimately consider treatment targets in complex clinical cases.

PMID: 37433422 - Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome

Innovation Rooted in Wisconsin

Advancing a Healthier Wisconsin – Momentum Award
This project investigates how genetic differences among Wisconsin residents affect medication response, particularly for mental health treatments. By analyzing local genetic data and comparing it to national patterns, we aim to identify unique variations influencing antidepressant and pain medication effectiveness. Partnering with Milwaukee communities, the study will also develop clear, trust-building communication strategies to increase awareness and participation in pharmacogenomic research and improve treatment outcomes across Wisconsin.

Contact Us

Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine (Mellowes Center)
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226

(414) 955-4887
(414) 955-6516 (fax)
mellowescenterinfo@mcw.edu

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