Main Campus Entrance-MKE

Kroner-Milsch Lab

Dr. Antje Kroner-Milsch

The overarching goal of my laboratory is to improve the quality of life and health of persons living with spinal cord injury (SCI). To achieve this goal, our work focuses on targeted control of the secondary tissue damage. Primary tissue damage, most often caused by a mechanical impact, is significantly worsened by multiple secondary processes, which include inflammation and hemorrhage. Current research in my lab is focused on tissue protection after SCI by interrupting hemorrhage induced and inflammatory processes which directly promote tissue damage and neuronal death and result in impaired functional outcome.

One research focus of my lab is the targeted inhibition of pro-inflammatory factors. This approach aims to specifically inhibit harmful, prolonged, and exacerbated inflammation, while maintaining the essential and tissue protective inflammatory processes. Previous experiments have shown the importance of pro-inflammatory factors in mediating inflammatory damage but also directly affecting neuronal survival and function, resulting in impaired recovery. A comprehensive understanding of inflammatory processes after SCI is essential for translational approaches in specifically targeting and inhibiting harmful mediators.

A second focus of my research investigates the role of hemorrhage after SCI. The reactivity of free hemoglobin and its downstream products induces a pronounced inflammatory and tissue toxic response. Interrupting this process will have a significant impact on the tissue preservation and functional outcome.

Ongoing Studies

Role of the Pro-inflammatory Cytokines IL-12 and IL-23 in Secondary Damage after Spinal Cord Injury
Funding: Department of Veterans Affairs, VA-ORD
The Functional Role and Therapeutic Potential of Heme Binding Proteins after Cervical SCI
Funding: Wings for Life

Recent Publications