Kroner-Milsch Lab
Dr. Antje Kroner-Milsch
The overarching goal of my laboratory is to improve the quality of life and health of persons living with spinal cord injury (SCI). To achieve this goal, our work focuses on targeted control of the secondary tissue damage. Primary tissue damage, most often caused by a mechanical impact, is significantly worsened by multiple secondary processes, which include inflammation and hemorrhage. Current research in my lab is focused on tissue protection after SCI by interrupting hemorrhage induced and inflammatory processes which directly promote tissue damage and neuronal death and result in impaired functional outcome.
One research focus of my lab is the targeted inhibition of pro-inflammatory factors. This approach aims to specifically inhibit harmful, prolonged, and exacerbated inflammation, while maintaining the essential and tissue protective inflammatory processes. Previous experiments have shown the importance of pro-inflammatory factors in mediating inflammatory damage but also directly affecting neuronal survival and function, resulting in impaired recovery. A comprehensive understanding of inflammatory processes after SCI is essential for translational approaches in specifically targeting and inhibiting harmful mediators.
A second focus of my research investigates the role of hemorrhage after SCI. The reactivity of free hemoglobin and its downstream products induces a pronounced inflammatory and tissue toxic response. Interrupting this process will have a significant impact on the tissue preservation and functional outcome.
Ongoing Studies
Recent Publications
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(St-Pierre MK, González Ibáñez F, Kroner A, Tremblay MÈ.) J Neuroinflammation. 2023 Nov 21;20(1):273 PMID: 37990235 PMCID: PMC10664529 11/22/2023
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Ferroptosis in Neurological Disease.
(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022
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Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.
(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023
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IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.
(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022
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(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021
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Correction to: CCL3 contributes to secondary damage after spinal cord injury.
(Pelisch N, Almanza JR, Stehlik KE, Aperi BV, Kroner A.) J Neuroinflammation. 2021 Apr 03;18(1):87 PMID: 33812368 PMCID: PMC8019158 04/05/2021
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(Pelisch N, Rosas Almanza J, Stehlik KE, Aperi BV, Kroner A.) eNeuro. 2021;8(2) PMID: 33632814 PMCID: PMC7986543 02/27/2021
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CCL3 contributes to secondary damage after spinal cord injury.
(Pelisch N, Rosas Almanza J, Stehlik KE, Aperi BV, Kroner A.) J Neuroinflammation. 2020 Nov 27;17(1):362 PMID: 33246483 PMCID: PMC7694914 11/29/2020
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Bilateral cervical contusion spinal cord injury: A mouse model to evaluate sensorimotor function.
(Reinhardt DR, Stehlik KE, Satkunendrarajah K, Kroner A.) Exp Neurol. 2020 Sep;331:113381 PMID: 32561411 SCOPUS ID: 2-s2.0-85086575731 06/21/2020
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Role of microglia in spinal cord injury.
(Kroner A, Rosas Almanza J.) Neurosci Lett. 2019 Sep 14;709:134370 PMID: 31283964 07/10/2019
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Myeloid cell responses after spinal cord injury.
(David S, Kroner A, Greenhalgh AD, Zarruk JG, López-Vales R.) J Neuroimmunol. 2018 Aug 15;321:97-108 PMID: 29957394 06/30/2018
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Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration.
(Kaplan A, Morquette B, Kroner A, Leong S, Madwar C, Sanz R, Banerjee SL, Antel J, Bisson N, David S, Fournier AE.) Neuron. 2017 Mar 08;93(5):1082-1093.e5 PMID: 28279353 03/11/2017