The Department of Radiation Oncology works in partnership with three different organizations to provide services at five locations. The largest site served is located in the Froedtert and Medical College Clinical Cancer Center. Froedtert Hospital and the Medical College of Wisconsin have had a long-standing partnership and is one of only two academic centers located in Wisconsin. The partnership between Froedtert Hospital and the Medical College of Wisconsin also provides the Department of Radiation Oncology an opportunity to provide services at Froedtert Menomonee Falls Hospital in Menomonee Falls, WI, Froedtert West Bend Hospital in West Bend, WI and Drexel Town Square Health Center in Oak Creek, WI. Services are also provided at the Clement J. Zablocki VA Medical Center located in Milwaukee, Wisconsin.

Among these five sites, the Department of Radiation Oncology treats approximately 2400 patients per year. Nineteen staff radiation oncologists and eight physician residents are involved in patient care as well as various in-house, national, and international cooperative group clinical protocols. At Froedtert Hospital, the primary location of the Medical Residency Program, approximately 1200 patients are treated annually. Froedtert Hospital provides the technical components (machines, equipment, dosimetry staff) of the radiation oncology department while the Medical College of Wisconsin provides the professional components (physicians, physicists, physician and physics residents, other academic faculty and staff).