Resuscitation Research Center

The Resuscitation Research Center (RRC) in the Department of Emergency Medicine department at the Medical College of Wisconsin is supported by federal funding to collaborate with researchers, clinicians and EMS at the local and national level on observational and interventional clinical trials in the areas of emergency resuscitation and neurological emergency research. The RRC has dedicated infrastructure to coordinate clinical trial activities 24/7.

The Resuscitation Research Center is also a regional site for two NIH funded research networks: the Resuscitation Outcomes Consortium and the Neurological Emergencies Treatment Trials Network.

Listen to Dr. Aufderheide's interview on WUWM's Lake Effect NPR (National Public Radio) interview where he discusses how a collaborative partnership between the Medical College of Wisconsin and Milwaukee County EMS has improved prehospital medical care and outcomes in Southeastern Wisconsin.

Resuscitation Outcomes Consortium (ROC)

ROC logoWhat is ROC?

The Resuscitation Outcomes Consortium (ROC) is a clinical research network consisting of 10 Regional Clinical Centers throughout the United States and Canada, as well as a Data Coordinating Center. It was created to study better ways to treat people that have an out-of-hospital cardiac arrest or a severe traumatic injury.

Why is ROC research important?

Cardiac arrest and traumatic injury are important public health problems. Heart disease is the most common cause of death in North America. Over 350,000 out-of-hospital cardiac arrests occur each year in the United States. Of those, less than 10% survive. Life-threatening severe injury is the leading cause of death in North America for persons between the ages of 1 and 44 years, and one of the leading causes of death in those over the age of 65 years.

For more information, visit the ROC website.
ROC Brochure (English) (PDF) | ROC Brochure (Spanish) (PDF)

Current ROC Clinical Trials at MCW

Amiodarone (PM101), Lidocaine, or Placebo for treatment of recurrent ventricular fibrillation or pulseless ventricular tachycardia in patients with out-of-hospital cardiac arrest.

Continuous Chest Compressions (CCC) CPR versus Standard AHA 30:2 CPR in patients with out-of-hospital cardiac arrest.

Prehospital Tranexamic Acid (TXA) use for treatment of patients with Traumatic Brain Injury (TBI).

Pragmatic trial of Airway Management in Out-of-Hospital Cardiac Arrest.

Neurological Emergencies Treatment Trials Network (NETT)

NETT LogoWhat is NETT?

The NIH has created a Neurological Emergencies Treatment Trials (NETT) Network to conduct large simple trials to reduce the burden of very acute injuries and illnesses affecting the brain, spinal cord, and peripheral nervous system. The network recognizes and seeks to explore the special narrow window of opportunity that seems to exist in treating neurologic damage from a variety of pathologies ranging from stroke to traumatic brain injury to seizures to meningitis. The study of very rapid interventions will have to be implemented by paramedics in the field, or by physicians in the Emergency Department. This network provides the basis for conducting efficient studies in these environments.

The mission of the Neurological Emergencies Treatment Trials (NETT) Network is to improve outcomes of patients with acute neurologic problems through innovative research focused on the emergent phase of patient care.

Current NETT Clinical Trials at MCW

Platelet-Oriented Inhibition in New TIA and Minor ischemic stroke (POINT) Trial

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

The Established Status Epilepticus Treatment Trial (ESETT)