About the Vedantam Laboratory
Finite Element Modeling of the Cervical Spinal Cord in Degenerative Cervical Myelopathy
Image: Finite element models of cervical spine
Spinal cord stress after anterior cervical diskectomy and fusion: results from a patient-specific finite element model
Implementing a Novel Virtual Reality Training Program for Hand Dexterity in Degenerative Cervical Myelopathy
Advanced Multi-parametric Imaging of the Spinal Cord in Degenerative Cervical Myelopathy
MCW has pioneered work in advanced spinal cord MR imaging. The Vedantam Lab, in collaboration with other investigators, is using multi-parametric MR imaging of the cervical spinal cord to improve the assessment of pre- and post-surgical spinal cord integrity in DCM. By combining advanced MRI with quantitative functional assessments, we are defining a set of MRI imaging biomarkers for DCM. We are working on the creation of a clinically useful set of MR sequences that can enhance diagnosis and prognosis for DCM.
Image: Magnetic resonance (MR) imaging of cervical spinal cord
- Diffusion tensor imaging in a large longitudinal series of patients with cervical spondylotic myelopathy correlated with long-term functional outcome
- Diffusion tensor imaging correlates with short-term myelopathy outcome in patients with cervical spondylotic myelopathy
- Diffusion tensor imaging of the spinal cord: insights from animal and human studies
- Characterization and limitations of diffusion tensor imaging metrics in the cervical spinal cord in neurologically intact subjects
Funding for the Vedantam Lab is provided by:
Dr. Aditya Vedantam, assistant professor of neurosurgery and Principal Investigator of the Vedantam Laboratory, attended medical school at the Christian Medical College and Hospital in Vellore, India, and then spent two years as a postdoctoral research fellow at the Medical College of Wisconsin, where he studied advanced MRI techniques to evaluate spinal cord disease. He completed his neurosurgery residency at Baylor College of Medicine in Houston, TX, followed by a fellowship in Minimally Invasive and Complex Spine Surgery at the University of Miami in Florida. Dr. Vedantam then returned to Milwaukee to continue to pursue his research interests, which include the use of novel MRI techniques and tools to improve care for patients with spinal disorders. He has performed extensive research in the field of spine MRI and has won national and institutional awards for his work. He has published over 50 peer-reviewed scientific manuscripts. His goal is to use his research efforts in the laboratory to enhance the lives of patients in the clinic.
The Vedantam Laboratory works closely with collaborators from the Medical College of Wisconsin, Marquette University and the University of North Carolina specializing in neurosurgery, neurology, neurophysiology, imaging, biostatistics, biomechanics and biomedical engineering.
Anjishnu Banerjee, PhD
Matthew D. Budde, PhD
Derek Kamper, PhD
Associate Professor of Biomedical Engineering
Kajana Satkunendrarajah, PhD
Assistant Professor, Department of Neurosurgery; Physiology
Priyanka Shah-Basak, PhD
Narayan Yoganandan, PhD
Professor & Chair of Biomechanics, Department of Neurosurgery; Orthopaedic Surgery; Joint Department of Biomedical Engineering
Current Lab Members
Current members of the Vedantam Laboratory include Principal Investigator Dr. Aditya Vedantam, as well as graduate students and professional research staff specializing in neurosurgery, neurotrauma, biomedical engineering and degenerative cervical myelopathy.
Aditya Vedantam, MD
Assistant Professor; Adjunct Faculty in Biomedical Engineering, Radiology, and Orthopedics
Robyn Furger, MA, CCRC
Clinical Research Coordinator, Brain Injury Research Program
Clinical Research Coordinator I
Clinical Research Assistant II
Spinal Cord Stress After Anterior Cervical Diskectomy and Fusion: Results from a Patient-Specific Finite Element Model.
(Vedantam A, Purushothaman Y, Harinathan B, Scripp S, Budde MD, Yoganandan N.) Ann Biomed Eng. 2023 May;51(5):1040-1051 PMID: 36538274 SCOPUS ID: 2-s2.0-85144374871 12/21/2022
Differences in spinal cord biomechanics after laminectomy, laminoplasty, and laminectomy with fusion for degenerative cervical myelopathy.
(Vedantam A, Harinathan B, Warraich A, Budde MD, Yoganandan N.) J Neurosurg Spine. 2023 Apr 07:1-12 PMID: 37029671 04/09/2023
The Evolving Profile of Acute Spinal Cord Injury Demographics, Outcomes and Surgical Treatment in North America: Analysis of a Prospective Multicenter Dataset of 989 Patients.
(Vedantam A, Ugiliweneza B, Williamson T, Guest J, Harrop JS, Tator C, Aarabi B, Fehlings MG, Kurpad SN, Neal CJ.) J Neurotrauma. 2022 Nov 30 PMID: 36448585 12/01/2022
A prospective multi-center study comparing the complication profile of modest systemic hypothermia versus normothermia for acute cervical spinal cord injury.
(Vedantam A, Jimsheleishvili G, Harrop JS, Alberga LR, Ahmad FU, Murphy RK, Jackson JB 3rd, Rodgers RB, Levi AD.) Spinal Cord. 2022 Jun;60(6):510-515 PMID: 35013548 01/12/2022
Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury.
(Gant KL, Guest JD, Palermo AE, Vedantam A, Jimsheleishvili G, Bunge MB, Brooks AE, Anderson KD, Thomas CK, Santamaria AJ, Perez MA, Curiel R, Nash MS, Saraf-Lavi E, Pearse DD, Widerström-Noga E, Khan A, Dietrich WD, Levi AD.) J Neurotrauma. 2022 Feb;39(3-4):285-299 PMID: 33757304 PMCID: PMC9360180 03/25/2021
Surgical Management of Postradiation, Dropped Head Spinal Deformity in Patients with Head and Neck Cancer.
(Verla T, Vedantam A, North RY, Xu DS, Raber MR, Fuentes A, Liou NE, Ropper AE.) World Neurosurg. 2021 Dec;156:e1-e8 PMID: 34245881 07/11/2021
Brain-Computer Interface, Neuromodulation, and Neurorehabilitation Strategies for Spinal Cord Injury.
(Cajigas I, Vedantam A.) Neurosurg Clin N Am. 2021 Jul;32(3):407-417 PMID: 34053728 06/01/2021
Hypothermia for Acute Spinal Cord Injury.
(Vedantam A, Levi AD.) Neurosurg Clin N Am. 2021 Jul;32(3):377-387 PMID: 34053725 06/01/2021
Early versus Late Profiles of Inflammatory Cytokines after Mild Traumatic Brain Injury and Their Association with Neuropsychological Outcomes.
(Vedantam A, Brennan J, Levin HS, McCarthy JJ, Dash PK, Redell JB, Yamal JM, Robertson CS.) J Neurotrauma. 2021 Jan 01;38(1):53-62 PMID: 32600167 PMCID: PMC7757539 07/01/2020
Use of Navigated Ultrasonic Bone Cutting Tool for En Bloc Resection of Thoracic Chondrosarcoma: Technical Report.
(Vedantam A, Vigneswaran K, Rao G, Walsh GL, Rhines LD, Tatsui CE.) Oper Neurosurg (Hagerstown). 2020 Oct 15;19(5):551-556 PMID: 32745212 08/04/2020
Limited midline myelotomy for visceral pain.
(Larkin MB, North RY, Vedantam A, Viswanathan A.) Neurosurg Focus Video. 2020 Oct;3(2):V16 PMID: 36285262 PMCID: PMC9542228 10/01/2020
Use of an Open-Frame Hinged Surgical Table to Restore Segmental Lumbar Lordosis After Posterior Column Osteotomy.
(Vedantam A, Verla T, Mayer RR, Raber MR, Ropper AE.) Int J Spine Surg. 2020 Jun;14(3):316-320 PMID: 32699753 PMCID: PMC7343252 07/24/2020
Get Involved with the Vedantam Lab
Researchers seeking graduate-level educational opportunities at the intersection of Neurosurgery and Neural Bioengineering are invited to explore opportunities in the Marquette-MCW Joint Department of Biomedical Engineering, as well as the Neuroscience Doctoral Program at the Medical College of Wisconsin.
Biomedical Engineering Graduate Studies
Undergraduate and high school students interested in gaining research experience in neuroscience and biomedical engineering labs are invited to explore undergraduate research opportunities supported by the Zablocki VA Medical Center Laboratories.
Student Research Opportunities at ZVAMC Labs
The Vedantam Laboratory is always on the lookout for individuals with an interest in spinal cord dysfunction, degenerative cervical myelopathy and the restoration of neurological function.
For general questions regarding open opportunities, contact Dr. Aditya Vedantam.