The Research Services Core (RSC) provides basic support for projects and programs in the department. The RSC facilities evolved from an original Program Project grant led by Dr. Cowley to a large group of professional engineers, machinists, computer programmers, systems analysts, histologists, and animal technicians who provide infrastructure support to all the research programs in the department. This core is supported from a variety of sources including, NIH grants, departmental resources, contracts, and institutional funds.
The department has had a longstanding involvement with bioinformatics and related technologies. The advent of physiological genomics and the widespread trend towards large-scale analyses and the resulting data management has driven this need. Bioinformatics research in the department ranges from individual databases and software applications that support internal research projects to large-scale public databases that provide data and bioinformatics tools for users worldwide. The Bioinformatics Program plays a central role in the bioinformatics projects, providing the core software and database development expertise that supports many other efforts.
Large-scale public programs
- Rat Genome Database
Online model organism database for the laboratory rat, Rattus norvegicus.
- PhysGen Program for Genomics Applications
PhysGen generates large quantities of physiological data linked to specific consomic rat strains. The PGA bioinformatics component is responsible for the database, website and statistical tools that enable researchers to utilize this rich data set.
- NHLBI National Proteomics Center
MCW houses one of ten U.S. proteomics centers. Its bioinformatics component focuses on data analysis and algorithms for MS/MS proteomics experiments.
Current computational biology research in the department includes projects designed to predict the behavior of large-scale biochemical networks, developing computational models of the transport and biochemical reaction of metabolites and other substances in the myocardium systems, and multiscale modeling of the heart in health and disease.