Kirby Laboratory
Location
Microbiology & Immunology
BSB B2410
General Interests
Bacterial Signal Transduction, Microbial Communities, Predator-Prey Dynamics, Xenobiotic Disruption of Microbiomes
Research Areas
Two-Component Signaling
We are taking a systems biology approach to characterize a family of two-component system homologs for their role during biofilm formation and predation by M. xanthus. Our primary area of interest aims to decipher cross-regulation between highly similar pairs of NtrB-NtrC homologs and chemosensory systems for their control of motility and development in M. xanthus.
Predator-Prey Interactions
We are actively investigating interactions between M. xanthus and B. subtilis as a model for predator-prey interactions in vivo. Our primary goal here is to assess the role of production of secondary metabolites on both sides of the predator-prey equation.
Microbiome
We are examining the role of xenobiotics for their capacity to disrupt the gut microbiota with deleterious consequences on metabolism. Currently, we utilize the Illumina platform to obtain 16s rDNA sequence information and analyze those data using QIIME (Quantitative Insights Into Microbial Ecology) open source software. We are employing the use of total calorimetry to assess metabolic defects in mice following perturbation with xenobiotics.
Current Members
Recent Publications
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(Tiwari N, López-Redondo M, Miguel-Romero L, Kulhankova K, Cahill MP, Tran PM, Kinney KJ, Kilgore SH, Al-Tameemi H, Herfst CA, Tuffs SW, Kirby JR, Boyd JM, McCormick JK, Salgado-Pabón W, Marina A, Schlievert PM, Fuentes EJ.) Proc Natl Acad Sci U S A. 2020 May 19;117(20):10989-10999 PMID: 32354997 05/02/2020
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(Bretl DJ, Ladd KM, Atkinson SN, Müller S, Kirby JR.) PLoS Genet. 2018 10;14(10):e1007714 PMID: 30346960 PMCID: PMC6211767 SCOPUS ID: 2-s2.0-85055910992 10/23/2018
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Ancient Regulatory Role of Lysine Acetylation in Central Metabolism.
(Nakayasu ES, Burnet MC, Walukiewicz HE, Wilkins CS, Shukla AK, Brooks S, Plutz MJ, Lee BD, Schilling B, Wolfe AJ, Müller S, Kirby JR, Rao CV, Cort JR, Payne SH.) mBio. 2017 11 28;8(6) PMID: 29184018 PMCID: PMC5705920 SCOPUS ID: 2-s2.0-85039922037 12/01/2017
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The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension.
(Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR.) Curr Hypertens Rep. 2017 Apr;19(4):27 PMID: 28316052 PMCID: PMC5773096 SCOPUS ID: 2-s2.0-85015782153 03/21/2017
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(Kelly PH, Bahr SM, Serafim TD, Ajami NJ, Petrosino JF, Meneses C, Kirby JR, Valenzuela JG, Kamhawi S, Wilson ME.) mBio. 2017 01 17;8(1) PMID: 28096483 PMCID: PMC5241394 SCOPUS ID: 2-s2.0-85014830318 01/18/2017
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(Müller S, Strack SN, Ryan SE, Shawgo M, Walling A, Harris S, Chambers C, Boddicker J, Kirby JR.) J Bacteriol. 2016 12 15;198(24):3335-3344 PMID: 27698086 PMCID: PMC5116937 SCOPUS ID: 2-s2.0-84996939200 10/05/2016
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(Bretl DJ, Müller S, Ladd KM, Atkinson SN, Kirby JR.) Mol Microbiol. 2016 10;102(1):37-53 PMID: 27393239 SCOPUS ID: 2-s2.0-84988461449 07/10/2016
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Molecular Mechanisms of Signaling in Myxococcus xanthus Development.
(Bretl DJ, Kirby JR.) J Mol Biol. 2016 09 25;428(19):3805-30 PMID: 27430596 SCOPUS ID: 2-s2.0-84986915805 07/20/2016
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(Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR.) EBioMedicine. 2015 11;2(11):1725-34 PMID: 26870798 PMCID: PMC4740326 SCOPUS ID: 2-s2.0-84958879311 02/13/2016
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(Bahr SM, Tyler BC, Wooldridge N, Butcher BD, Burns TL, Teesch LM, Oltman CL, Azcarate-Peril MA, Kirby JR, Calarge CA.) Transl Psychiatry. 2015 Oct 06;5:e652 PMID: 26440540 PMCID: PMC4930121 SCOPUS ID: 2-s2.0-84943422862 10/07/2015
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Predation by Myxococcus xanthus induces Bacillus subtilis to form spore-filled megastructures.
(Müller S, Strack SN, Ryan SE, Kearns DB, Kirby JR.) Appl Environ Microbiol. 2015 Jan;81(1):203-10 PMID: 25326308 PMCID: PMC4272737 SCOPUS ID: 2-s2.0-84917705880 10/19/2014