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Research Bench Lab

Kelliher Laboratory

Kelliher Lab host-pathogen interactions in the cytosol

Location
Microbiology & Immunology}
BSB B2315

General Interests
Host-pathogen interactions, cell-autonomous immunity, bacterial pathogenesis, bacterial genetics and physiology, bacterial signal transduction

View Jessica Kelliher Bio

Jessica Kelliler, PhD Lab

Research Areas

In the Kelliher lab, we are broadly interested in investigating host-pathogen interactions at the molecular level, with the goal of developing better therapeutics for treating bacterial infections. More specifically, we are interested in understanding host and pathogen factors that drive infection outcomes in the mammalian cytosol, a relatively under-studied host-pathogen interface. While some pathogens have evolved to reach and replicate in the cytosol, non-adapted microbes are killed through largely unknown cell-autonomous defenses. We investigate both the cytosolic defenses that target microbes in this environment, as well as the adaptations that professional cytosolic pathogens possess that enable them to survive and thrive in this restrictive niche.

Current Members

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Carly Mascari, PhD

Postdoctoral Researcher, Kelliher Lab

cmascari@mcw.edu

Recent Publications