Brockman Laboratory

Location

Microbiology & Immunology

BSB | Office: B2935, Lab: B2620

General Interests

Microbial Pathogenesis, Bacterial Gene Regulation, Host-Microbe Interactions

View Kenneth L. Brockman Bio

Research Areas

Bacterial pathogens use a wide range of mechanisms to adapt to and persist under diverse environmental conditions and stressors found in their human host. Our current research is focused on defining the role of a novel regulatory system, the phasevarion, in the pathogenesis of diseases caused by several human pathogens which include, Haemophilus influenzae, Moraxella catharrhalis, Helicobacter pylori and Neisseria species.

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Current Members

Brandon Wills

Research Technologist II

bwills@mcw.edu

Preeti Garai, PhD

Posdoctoral Fellow

pgarai@mcw.edu

Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019.

(Thornton RB, Hakansson A, Hood DW, Nokso-Koivisto J, Preciado D, Riesbeck K, Richmond PC, Su YC, Swords WE, Brockman KL.) Int J Pediatr Otorhinolaryngol. 2020 Mar;130 Suppl 1:109838 PMID: 31879085 PMCID: PMC7062565 SCOPUS ID: 2-s2.0-85076859531 12/28/2019
Regulation and Maturation of the Shewanella oneidensis Sulfite Reductase SirA.

(Brockman KL, Shirodkar S, Croft TJ, Banerjee R, Saffarini DA.) Sci Rep. 2020 01 22;10(1):953 PMID: 31969587 PMCID: PMC6976685 SCOPUS ID: 2-s2.0-85078139745 01/24/2020
The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection.

(Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S.) Front Immunol. 2020;11:97 PMID: 32117251 PMCID: PMC7010865 SCOPUS ID: 2-s2.0-85079677223 03/03/2020
The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection

(Robledo-Avila FH, Ruiz-Rosado JdD, Brockman KL, Partida-Sánchez S.) Frontiers in Immunology. 4 February 2020;11 SCOPUS ID: 2-s2.0-85079677223 02/04/2020
Streptococcus oralis subsp. dentisani Produces Monolateral Serine-Rich Repeat Protein Fibrils, One of Which Contributes to Saliva Binding via Sialic Acid.

(Ronis A, Brockman K, Singh AK, Gaytán MO, Wong A, McGrath S, Owen CD, Magrini V, Wilson RK, van der Linden M, King SJ.) Infect Immun. 2019 10;87(10) PMID: 31308084 PMCID: PMC6759294 SCOPUS ID: 2-s2.0-85072508552 07/17/2019
Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae.

(Novotny LA, Brockman KL, Mokrzan EM, Jurcisek JA, Bakaletz LO.) J Pediatr Infect Dis. 2019 Feb;14(2):69-77 PMID: 30853830 PMCID: PMC6402341 03/12/2019
Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm.

(Mokrzan EM, Novotny LA, Brockman KL, Bakaletz LO.) mBio. 2018 12 11;9(6) PMID: 30538189 PMCID: PMC6299487 SCOPUS ID: 2-s2.0-85058590472 12/13/2018
Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.

(Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S.) J Immunol. 2018 10 01;201(7):2016-2027 PMID: 30120123 PMCID: PMC6143431 SCOPUS ID: 2-s2.0-85053469523 08/19/2018
Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae.

(Brockman KL, Azzari PN, Branstool MT, Atack JM, Schulz BL, Jen FE, Jennings MP, Bakaletz LO.) mBio. 2018 09 18;9(5) PMID: 30228240 PMCID: PMC6143736 SCOPUS ID: 2-s2.0-85055490499 09/20/2018
The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans.

(Atack JM, Day CJ, Poole J, Brockman KL, Bakaletz LO, Barenkamp SJ, Jennings MP.) Biochem Biophys Res Commun. 2018 09 05;503(2):1103-1107 PMID: 29944882 PMCID: PMC6095747 SCOPUS ID: 2-s2.0-85048968279 06/27/2018
Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

(Jurcisek JA, Brockman KL, Novotny LA, Goodman SD, Bakaletz LO.) Proc Natl Acad Sci U S A. 2017 08 08;114(32):E6632-E6641 PMID: 28696280 PMCID: PMC5559034 SCOPUS ID: 2-s2.0-85026867309 07/12/2017
The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.

(Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO.) Sci Rep. 2017 06 09;7(1):3161 PMID: 28600561 PMCID: PMC5466613 SCOPUS ID: 2-s2.0-85020676207 06/11/2017