Riehle Laboratory

Location

Microbiology & Immunology
BSB B2920

General Interests

Malaria Vector Biology, Genetics of Susceptibility, Microbiome and Immunity

Research Areas

Malaria remains a major global health problem leading to significant human morbidity and mortality. The World Health Organization reports that about half a million people die of malaria each year with most of these deaths occurring in children in Sub-Saharan Africa. Significant gains in malaria control have been made in recent years largely on the backs of concerted vector control efforts including the use of bed nets and insecticides. Our area of research focuses on understanding the dynamics of the relationship between the mosquito vector and the malaria parasite, Plasmodium falciparum. Through a better understanding of this relationship we can inform the design of future control strategies aimed at malaria eradication.

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Current Members

Cameron Anderson

Research Technologist I

caanderson@mcw.edu

Heather L. Eggleston, PhD

Postdoctoral Fellow

heggleston@mcw.edu

Kimani Njoya

Graduate Student

knjoya@mcw.edu

Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia.

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Jun 09;11(1):12553 PMID: 34108534 PMCID: PMC8190266 SCOPUS ID: 2-s2.0-85107408524 06/11/2021
Anopheles ecology, genetics and malaria transmission in northern Cambodia.

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 03 19;11(1):6458 PMID: 33742030 PMCID: PMC7979810 SCOPUS ID: 2-s2.0-85102850695 03/21/2021
Discovery of Ongoing Selective Sweeps within Anopheles Mosquito Populations Using Deep Learning.

(Xue AT, Schrider DR, Kern AD, Ag1000g Consortium.) Mol Biol Evol. 2021 03 09;38(3):1168-1183 PMID: 33022051 PMCID: PMC7947845 SCOPUS ID: 2-s2.0-85102911117 10/07/2020
Filtering the Junk: Assigning Function to the Mosquito Non-Coding Genome.

(Farley EJ, Eggleston H, Riehle MM.) Insects. 2021 Feb 22;12(2) PMID: 33671692 PMCID: PMC7926655 03/07/2021
Anopheles ecology, genetics and malaria transmission in northern Cambodia

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85102850695 12/01/2021
Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia (Scientific Reports, (2021), 11, 1, (6458), 10.1038/s41598-021-85628-1)

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85107408524 12/01/2021
Comprehensive Ecological and Geographic Characterization of Eukaryotic and Prokaryotic Microbiomes in African Anopheles.

(Cuesta EB, Coulibaly B, Bukhari T, Eiglmeier K, Kone R, Coulibaly MB, Zongo S, Barry M, Gneme A, Guelbeogo WM, Beavogui AH, Traore SF, Sagnon N, Vernick KD, Riehle MM.) Front Microbiol. 2021;12:635772 PMID: 34054746 PMCID: PMC8153677 06/01/2021
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

(Grau-Bové X, Lucas E, Pipini D, Rippon E, van ‘t Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski DP, Donnelly MJ, Weetman D, Amaya-Romero JE, Ayala D, Battey CJ, Bejon P, Besansky NJ, Burt A, Cano J, Caputo B, Constant E, Costantini C, Coulibaly B, della Torre A, Diabaté A, Dinis J, Donnelly MJ, Drury E, Edouardo J, Elissa N, Essandoh J, Fontaine MC, Godfray CHJ, Hahn MW, Harding NJ, Henrichs C, Hubbart C, Isaacs AT, Jawara M, Jeffreys AE, Jyothi D, Kamali M, Kern AD, Clarkson CS, Lawniczak MKN, Le Goff G, Lucas E, Malangone C, Mawejje HD, Mbogo C, Mead D, Midega J, Miles A, Nwakanma DC, O’Loughlin S, Pinto J, Riehle MM, Robert V, Rockett KA, Rohatgi KR, Rowlands K, Schrider DR, Sharakhov I, Simpson V, Stalker J, Troco AD, Vernick KD, Weetman D, Bradley J.) PLoS Genetics. 21 January 2021;17(1) SCOPUS ID: 2-s2.0-85099805834 01/21/2021
Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii.

(Anopheles gambiae 1000 Genomes Consortium.) Genome Res. 2020 10;30(10):1533-1546 PMID: 32989001 PMCID: PMC7605271 SCOPUS ID: 2-s2.0-85092682445 09/30/2020
Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium.

(Dieme C, Zmarlak NM, Brito-Fravallo E, Travaillé C, Pain A, Cherrier F, Genève C, Calvo-Alvarez E, Riehle MM, Vernick KD, Rotureau B, Mitri C.) PLoS Negl Trop Dis. 2020 02;14(2):e0008059 PMID: 32032359 PMCID: PMC7032731 SCOPUS ID: 2-s2.0-85081144453 02/08/2020
Gene copy number and function of the APL1 immune factor changed during Anopheles evolution.

(Mitri C, Bischoff E, Eiglmeier K, Holm I, Dieme C, Brito-Fravallo E, Raz A, Zakeri S, Nejad MIK, Djadid ND, Vernick KD, Riehle MM.) Parasit Vectors. 2020 Jan 13;13(1):18 PMID: 31931885 PMCID: PMC6958605 SCOPUS ID: 2-s2.0-85077786231 01/15/2020
Leucine-Rich Immune Factor APL1 Is Associated With Specific Modulation of Enteric Microbiome Taxa in the Asian Malaria Mosquito Anopheles stephensi.

(Mitri C, Bischoff E, Belda Cuesta E, Volant S, Ghozlane A, Eiglmeier K, Holm I, Dieme C, Brito-Fravallo E, Guelbeogo WM, Sagnon N, Riehle MM, Vernick KD.) Front Microbiol. 2020;11:306 PMID: 32174902 PMCID: PMC7054466 03/17/2020

Microbiology & Immunology