Riehle Laboratory

Location
Microbiology & Immunology
BSB B2920

General Interests
Malaria Vector Biology, Genetics of Susceptibility, Microbiome and Immunity

Research Areas

Malaria remains a major global health problem leading to significant human morbidity and mortality. The World Health Organization reports that about half a million people die of malaria each year with most of these deaths occurring in children in Sub-Saharan Africa. Significant gains in malaria control have been made in recent years largely on the backs of concerted vector control efforts including the use of bed nets and insecticides. Our area of research focuses on understanding the dynamics of the relationship between the mosquito vector and the malaria parasite, Plasmodium falciparum. Through a better understanding of this relationship we can inform the design of future control strategies aimed at malaria eradication.

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Current Members

Cameron Anderson

Research Technologist, Riehle Lab

caanderson@mcw.edu

Kathryn Taquet

G2 Student

ktaquet@mcw.edu

Kimani Njoya

Graduate Student

knjoya@mcw.edu

Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B.

(Eggleston H, Njoya K, Anderson CE, Holm I, Eiglmeier K, Liang J, Sharakhov IV, Vernick KD, Riehle MM.) Parasit Vectors. 2022 Dec 13;15(1):465 PMID: 36514125 PMCID: PMC9749150 SCOPUS ID: 2-s2.0-85143791043 12/14/2022
Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium.

(Bukhari T, Aimanianda V, Bischoff E, Brito-Fravallo E, Eiglmeier K, Riehle MM, Vernick KD, Mitri C.) Sci Rep. 2022 Apr 15;12(1):6315 PMID: 35428783 PMCID: PMC9012835 SCOPUS ID: 2-s2.0-85128387936 04/17/2022
Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia.

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Jun 09;11(1):12553 PMID: 34108534 PMCID: PMC8190266 SCOPUS ID: 2-s2.0-85107408524 06/11/2021
Anopheles ecology, genetics and malaria transmission in northern Cambodia.

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Mar 19;11(1):6458 PMID: 33742030 PMCID: PMC7979810 SCOPUS ID: 2-s2.0-85102850695 03/21/2021
Discovery of Ongoing Selective Sweeps within Anopheles Mosquito Populations Using Deep Learning.

(Xue AT, Schrider DR, Kern AD, Ag1000g Consortium.) Mol Biol Evol. 2021 Mar 09;38(3):1168-1183 PMID: 33022051 PMCID: PMC7947845 SCOPUS ID: 2-s2.0-85102911117 10/07/2020
Filtering the Junk: Assigning Function to the Mosquito Non-Coding Genome.

(Farley EJ, Eggleston H, Riehle MM.) Insects. 2021 Feb 22;12(2) PMID: 33671692 PMCID: PMC7926655 03/07/2021
Comprehensive Genomic Discovery of Non-Coding Transcriptional Enhancers in the African Malaria Vector Anopheles coluzzii.

(Holm I, Nardini L, Pain A, Bischoff E, Anderson CE, Zongo S, Guelbeogo WM, Sagnon N, Gohl DM, Nowling RJ, Vernick KD, Riehle MM.) Front Genet. 2021;12:785934 PMID: 35082832 PMCID: PMC8784733 01/28/2022
Anopheles ecology, genetics and malaria transmission in northern Cambodia

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85102850695 12/01/2021
Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia (Scientific Reports, (2021), 11, 1, (6458), 10.1038/s41598-021-85628-1)

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85107408524 12/01/2021
Comprehensive Ecological and Geographic Characterization of Eukaryotic and Prokaryotic Microbiomes in African Anopheles.

(Cuesta EB, Coulibaly B, Bukhari T, Eiglmeier K, Kone R, Coulibaly MB, Zongo S, Barry M, Gneme A, Guelbeogo WM, Beavogui AH, Traore SF, Sagnon N, Vernick KD, Riehle MM.) Front Microbiol. 2021;12:635772 PMID: 34054746 PMCID: PMC8153677 06/01/2021
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

(Grau-Bové X, Lucas E, Pipini D, Rippon E, van ‘t Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski DP, Donnelly MJ, Weetman D, Amaya-Romero JE, Ayala D, Battey CJ, Bejon P, Besansky NJ, Burt A, Cano J, Caputo B, Constant E, Costantini C, Coulibaly B, della Torre A, Diabaté A, Dinis J, Donnelly MJ, Drury E, Edouardo J, Elissa N, Essandoh J, Fontaine MC, Godfray CHJ, Hahn MW, Harding NJ, Henrichs C, Hubbart C, Isaacs AT, Jawara M, Jeffreys AE, Jyothi D, Kamali M, Kern AD, Clarkson CS, Lawniczak MKN, Le Goff G, Lucas ER, Malangone C, Mawejje HD, Mbogo C, Mead D, Midega J, Miles A, Nwakanma DC, O’Loughlin S, Pinto J, Riehle MM, Robert V, Rockett KA, Rohatgi KR, Rowlands K, Schrider DR, Sharakhov I, Simpson V, Stalker J, Troco AD, Vernick KD, Weetman D, Bradley J.) PLoS Genetics. 21 January 2021;17(1) SCOPUS ID: 2-s2.0-85099805834 01/21/2021
Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii.

(Anopheles gambiae 1000 Genomes Consortium.) Genome Res. 2020 Oct;30(10):1533-1546 PMID: 32989001 PMCID: PMC7605271 SCOPUS ID: 2-s2.0-85092682445 09/30/2020