Leading the Way in Discovering Novel Treatments for Pancreatic Cancer
Commitment to Research
The LaBahn Pancreatic Cancer Program supports internationally recognized specialists who provide a wealth of knowledge and experience in pancreatic cancer treatment and research. We are committed to developing the next generation of medical researchers and to translating our research into cutting-edge treatments for our patients. We are involved in many areas of research, including basic science, outcomes assessments, and international clinical trials. Our dedication to research is one of the many tools we have available to make MCW a destination for the best pancreatic cancer care possible.
About our Biorepository
Our biorepository is a phenomenal resource for both translational research collaborations as well as clinical outcomes research. The Ronald Burklund Eich integrated biorepository and database captures longitudinal samples from patients across a broad spectrum of disease, from pancreatic cancer screening to diagnosis, and even post-mortem.
Basic and Translational Scientific Investigators
Scientific investigators are discovery-drivers, working to uncover more innovative and cutting-edge treatments with every study they conduct.

Michael B. Dwinell, PhD
Professor; Founding Director, Center for Immunology; Director, Bobbie Nick Voss Laboratory for Colon Cancer Research; Leader, Molecular Cancer Therapeutics
Cancer Metastasis, Tumor Microenvironment, Mucosal Inflammation

Gwen Lomberk, PhD
Chief, Division of Research; Director, Basic Science Research; Department of Surgery; Associate Professor of Surgery and Pharmacology & Toxicology

Marja T. Nevalainen, MD, PhD
Professor, Eminent Scholar, Department of Pathology and Pharmacology & Toxicology; Assistant Dean of Research, Medical College of Wisconsin; Associate Director (Education), Medical College of Wisconsin Cancer Center; Director, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center
Dr. Nevalainen is an internationally recognized leader in the field of cytokine and steroid hormone signaling in prostate cancer. Dr. Nevalainen holds the title of Eminent Scholar at MCW. She is also Director of Prostate Cancer Center of Excellence at MCW Cancer Center, which is a multi-disciplinary hub for prostate cancer research within the institution with an international collaborative network. She also serves as Associate Director of Education for the MCW Cancer Center.

Jong-In Park, PhD
Professor

Raul A. Urrutia, MD
Professor, Department of Surgery; Director, Genomic Sciences and Precision Medicine Center
Research Lab Links and More
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Department of Surgery- Division of Research
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Dr. Dwinell's Lab Page
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Dr. Lomberk's Lab Page
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Dr. Park's Lab Page
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Dr. Urrutia's Lab Page
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Recent Publications
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(Wu PK, Hong SK, Park JI.) Cancer Lett. 2021 Apr 01;502:25-33 PMID: 33440231 PMCID: PMC7897271 01/14/2021
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(Chi YI, Stodola TJ, De Assuncao TM, Levrence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Orphanet J Rare Dis. 2021 Feb 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021
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(Vonderhaar EP, Barnekow NS, McAllister D, McOlash L, Eid MA, Riese MJ, Tarakanova VL, Johnson BD, Dwinell MB.) Cell Mol Gastroenterol Hepatol. 2021 Feb 04 PMID: 33548597 02/07/2021
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Two-Stage Hepatectomy for Bilateral Colorectal Liver Metastases: A Multi-institutional Analysis
(Chavez MI, Gholami S, Kim BJ, Margonis GA, Ethun CG, Tsai S, Christians KK, Clarke C, Mogal H, Maithel SK, Pawlik TM, D’Angelica MI, Aloia TA, Eastwood D, Gamblin TC.) Annals of Surgical Oncology. 2021 SCOPUS ID: 2-s2.0-85098739759 01/01/2021
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Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA.
(Gao C, Wisniewski L, Liu Y, Staal B, Beddows I, Plenker D, Aldakkak M, Hall J, Barnett D, Gouda MK, Allen P, Drake R, Zureikat A, Huang Y, Evans D, Singhi A, Brand RE, Tuveson DA, Tsai S, Haab BB.) Clin Cancer Res. 2021 Jan 01;27(1):226-236 PMID: 33093149 PMCID: PMC7785673 SCOPUS ID: 2-s2.0-85100339220 10/24/2020
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(Tsai S, Pawlik TM.) Ann Surg Oncol. 2021 Jan;28(1):24-26 PMID: 32951090 SCOPUS ID: 2-s2.0-85091239152 09/21/2020
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(Wang Y, Wu J, Chen H, Yang Y, Xiao C, Yi X, Shi C, Zhong K, He H, Li Y, Wu Z, Zhou G, Rao Q, Wang X, Zhou X, Lomberk G, Liu B, Zhao J, Ge J, Zhou W, Chu X, Chen C, Zhou X, Wang L, Guan K, Qu L.) Science Advances. 27 January 2021;7(5) SCOPUS ID: 2-s2.0-85099945962 01/27/2021
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(Mora J, Krepline AN, Aldakkak M, Christians KK, George B, Hall WA, Erickson BA, Kulkarni N, Evans DB, Tsai S.) Am J Surg. 2020 Dec 03 PMID: 33308823 SCOPUS ID: 2-s2.0-85097458297 12/15/2020
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Variant anatomy of the biliary system as a cause of pancreatic and peri-ampullary cancers.
(Muraki T, Reid MD, Pehlivanoglu B, Gonzalez RS, Sekhar A, Memis B, Xue Y, Cheng J, Jang KT, Mittal P, Cardona K, Kooby DA, Maithel S, Sarmiento JM, El-Rayes B, Lomberk G, Urrutia RA, Christians K, Tsai S, Evans DB, Adsay V.) HPB (Oxford). 2020 Dec;22(12):1675-1685 PMID: 32336556 SCOPUS ID: 2-s2.0-85083637358 04/28/2020
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Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer.
(Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG.) FASEB J. 2020 Dec;34(12):16034-16048 PMID: 33047385 SCOPUS ID: 2-s2.0-85092336914 10/14/2020
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(Tripathi S, Dsouza NR, Urrutia R, Zimmermann MT.) Bioinformatics. 2020 Nov 23 PMID: 33226070 11/24/2020
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(Salama AKS, Li S, Macrae ER, Park JI, Mitchell EP, Zwiebel JA, Chen HX, Gray RJ, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Armstrong DK, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT.) J Clin Oncol. 2020 Nov 20;38(33):3895-3904 PMID: 32758030 PMCID: PMC7676884 08/08/2020
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(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
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(Muraki T, Pehlivanoglu B, Memis B, Reid MD, Uehara T, Basturk O, Pernicka JG, Klimstra DS, Jarnagin WR, Ito T, Hasebe O, Okaniwa S, Horigome N, Hisa T, Mittal P, Sarmiento JM, Maithel SK, Koshiol J, Tsai S, Evans D, Erkan M, Adsay V.) Ann Surg. 2020 Nov 12 PMID: 33201123 11/18/2020
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Impact of integrated translational research on clinical exome sequencing.
(Klee EW, Cousin MA, Pinto E Vairo F, Morales-Rosado JA, Macke EL, Jenkinson WG, Ferrer A, Schultz-Rogers LE, Olson RJ, Oliver GR, Sigafoos AN, Schwab TL, Zimmermann MT, Urrutia RA, Kaiwar C, Gupta A, Blackburn PR, Boczek NJ, Prochnow CA, Lowy RJ, Mulvihill LA, McAllister TM, Aoudia SL, Kruisselbrink TM, Gunderson LB, Kemppainen JL, Fisher LJ, Tarnowski JM, Hager MM, Kroc SA, Bertsch NL, Agre KE, Jackson JL, Macklin-Mantia SK, Murphree MI, Rust LM, Summer Bolster JM, Beck SA, Atwal PS, Ellingson MS, Barnett SS, Rasmussen KJ, Lahner CA, Niu Z, Hasadsri L, Ferber MJ, Marcou CA, Clark KJ, Pichurin PN, Deyle DR, Morava-Kozicz E, Gavrilova RH, Dhamija R, Wierenga KJ, Lanpher BC, Babovic-Vuksanovic D, Farrugia G, Schimmenti LA, Stewart AK, Lazaridis KN.) Genet Med. 2020 Nov 04 PMID: 33144682 11/05/2020
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(Hall WA, Sabharwal L, Udhane V, Maranto C, Nevalainen MT.) Int J Biochem Cell Biol. 2020 10;127:105827 PMID: 32822847 SCOPUS ID: 2-s2.0-85090734995 08/22/2020
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Total Neoadjuvant Therapy for Operable Pancreatic Cancer.
(Kim RY, Christians KK, Aldakkak M, Clarke CN, George B, Kamgar M, Khan AH, Kulkarni N, Hall WA, Erickson BA, Evans DB, Tsai S.) Ann Surg Oncol. 2020 Sep 30 PMID: 33000372 SCOPUS ID: 2-s2.0-85091728559 10/02/2020
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(Chakrabarti S, Xie H, Urrutia R, Mahipal A.) Cancers (Basel). 2020 09 29;12(10) PMID: 33003583 PMCID: PMC7601010 10/03/2020
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(Lan W, Santofimia-Castaño P, Swayden M, Xia Y, Zhou Z, Audebert S, Camoin L, Huang C, Peng L, Jiménez-Alesanco A, Velázquez-Campoy A, Abián O, Lomberk G, Urrutia R, Rizzuti B, Geli V, Soubeyran P, Neira JL, Iovanna J.) JCI Insight. 2020 09 17;5(18) PMID: 32780723 PMCID: PMC7526551 SCOPUS ID: 2-s2.0-85090785767 08/12/2020
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(Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):057501 PMID: 33062803 PMCID: PMC7550797 10/17/2020
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Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats.
(Kim J, Hagen CE, Kumar SN, Park JI, Zimmerman MA, Hong JC.) Transplant Direct. 2020 Aug;6(8):e584 PMID: 32766432 PMCID: PMC7371100 SCOPUS ID: 2-s2.0-85094858644 08/09/2020
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Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway.
(Wu PK, Becker A, Park JI.) Int J Mol Sci. 2020 Jul 30;21(15) PMID: 32751750 PMCID: PMC7432891 SCOPUS ID: 2-s2.0-85089131301 08/06/2020
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(Wu PK, Hong SK, Starenki D, Oshima K, Shao H, Gestwicki JE, Tsai S, Park JI.) Oncogene. 2020 05;39(21):4257-4270 PMID: 32291414 PMCID: PMC7244387 SCOPUS ID: 2-s2.0-85083767959 04/16/2020
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Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21.
(Moussouras NA, Hjortø GM, Peterson FC, Szpakowska M, Chevigné A, Rosenkilde MM, Volkman BF, Dwinell MB.) Biochemistry. 2020 04 07;59(13):1338-1350 PMID: 32182428 PMCID: PMC7307649 SCOPUS ID: 2-s2.0-85083041593 03/18/2020
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(Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI.) Sci Signal. 2020 03 10;13(622) PMID: 32156782 PMCID: PMC7099430 SCOPUS ID: 2-s2.0-85081677231 03/12/2020
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(Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G.) Mol Cancer Res. 2020 03;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019
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(Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 02 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019
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(Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B.) Cancer Treat Res Commun. 2020;25:100210 PMID: 32987287 PMCID: PMC7883397 SCOPUS ID: 2-s2.0-85091576205 09/29/2020
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(Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G.) PLoS One. 2020;15(2):e0217452 PMID: 32027651 PMCID: PMC7004349 SCOPUS ID: 2-s2.0-85079081692 02/07/2020
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(Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, See WA, Mirtti T, Kilari D, Nevalainen MT.) Mol Cancer Ther. 2020 01;19(1):231-246 PMID: 31548294 PMCID: PMC6946850 SCOPUS ID: 2-s2.0-85077669370 09/25/2019
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Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.
(Santofimia-Castaño P, Xia Y, Peng L, Velázquez-Campoy A, Abián O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J.) Cells. 2019 11 17;8(11) PMID: 31744261 PMCID: PMC6912534 SCOPUS ID: 2-s2.0-85082729502 11/21/2019
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(Haddad BR, Erickson A, Udhane V, LaViolette PS, Rone JD, Kallajoki MA, See WA, Rannikko A, Mirtti T, Nevalainen MT.) Cancer Epidemiol Biomarkers Prev. 2019 10;28(10):1642-1651 PMID: 31292140 PMCID: PMC6774884 SCOPUS ID: 2-s2.0-85072849403 07/12/2019
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(Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B.) Oncotarget. 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 06/14/2019
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(Jing W, McAllister D, Vonderhaar EP, Palen K, Riese MJ, Gershan J, Johnson BD, Dwinell MB.) J Immunother Cancer. 2019 04 29;7(1):115 PMID: 31036082 PMCID: PMC6489306 SCOPUS ID: 2-s2.0-85065258266 05/01/2019
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Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space.
(McGarry SD, Bukowy JD, Iczkowski KA, Unteriner JG, Duvnjak P, Lowman AK, Jacobsohn K, Hohenwalter M, Griffin MO, Barrington AW, Foss HE, Keuter T, Hurrell SL, See WA, Nevalainen MT, Banerjee A, LaViolette PS.) Tomography. 2019 03;5(1):127-134 PMID: 30854450 PMCID: PMC6403022 SCOPUS ID: 2-s2.0-85071529534 03/12/2019