Recent Publications

• Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

  (Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S.) Elife. 2020 May 14;9 PMID: 32406817 05/15/2020

• Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.

  (Wu PK, Hong SK, Starenki D, Oshima K, Shao H, Gestwicki JE, Tsai S, Park JI.) Oncogene. 2020 May;39(21):4257-4270 PMID: 32291414 PMCID: PMC7244387 SCOPUS ID: 2-s2.0-85083767959 04/16/2020

• Variant anatomy of the biliary system as a cause of pancreatic and peri-ampullary cancers.

  (Muraki T, Reid MD, Pehlivanoglu B, Gonzalez RS, Sekhar A, Memis B, Xue Y, Cheng J, Jang KT, Mittal P, Cardona K, Kooby DA, Maithel S, Sarmiento JM, El-Rayes B, Lomberk G, Urrutia RA, Christians K, Tsai S, Evans DB, Adsay V.) HPB (Oxford). 2020 Apr 23 PMID: 32336556 SCOPUS ID: 2-s2.0-85083637358 04/28/2020

• Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21.

  (Moussouras NA, Hjortø GM, Peterson FC, Szpakowska M, Chevigné A, Rosenkilde MM, Volkman BF, Dwinell MB.) Biochemistry. 2020 Apr 07;59(13):1338-1350 PMID: 32182428 SCOPUS ID: 2-s2.0-85083041593 03/18/2020

• Importance of Normalization of CA19-9 Levels Following Neoadjuvant Therapy in Patients With Localized Pancreatic Cancer.

  (Tsai S, George B, Wittmann D, Ritch PS, Krepline AN, Aldakkak M, Barnes CA, Christians KK, Dua K, Griffin M, Hagen C, Hall WA, Erickson BA, Evans DB.) Ann Surg. 2020 04;271(4):740-747 PMID: 30312198 SCOPUS ID: 2-s2.0-85082099572 10/13/2018

• Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.

  (Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI.) Sci Signal. 2020 Mar 10;13(622) PMID: 32156782 PMCID: PMC7099430 SCOPUS ID: 2-s2.0-85081677231 03/12/2020

• Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse.

  (Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G.) Mol Cancer Res. 2020 03;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019

• Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis.

  (Seminary ER, Santarriaga S, Wheeler L, Mejaki M, Abrudan J, Demos W, Zimmermann MT, Urrutia RA, Fee D, Barkhaus PE, Ebert AD.) Cells. 2020 Feb 28;9(3) PMID: 32121108 PMCID: PMC7140469 03/04/2020

• PAX1 is essential for development and function of the human thymus.

  (Yamazaki Y, Urrutia R, Franco LM, Giliani S, Zhang K, Alazami AM, Dobbs AK, Masneri S, Joshi A, Otaizo-Carrasquero F, Myers TG, Ganesan S, Bondioni MP, Ho ML, Marks C, Alajlan H, Mohammed RW, Zou F, Valencia CA, Filipovich AH, Facchetti F, Boisson B, Azzari C, Al-Saud BK, Al-Mousa H, Casanova JL, Abraham RS, Notarangelo LD.) Sci Immunol. 2020 02 28;5(44) PMID: 32111619 PMCID: PMC7189207 SCOPUS ID: 2-s2.0-85081071846 03/01/2020

• Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.

  (Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 Feb 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019

• Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors.

  (Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, See WA, Mirtti T, Kilari D, Nevalainen MT.) Mol Cancer Ther. 2020 01;19(1):231-246 PMID: 31548294 PMCID: PMC6946850 SCOPUS ID: 2-s2.0-85077669370 09/25/2019

• Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.

  (Fong L, Hotson A, Powderly JD, Sznol M, Heist RS, Choueiri TK, George S, Hughes BGM, Hellmann MD, Shepard DR, Rini BI, Kummar S, Weise AM, Riese MJ, Markman B, Emens LA, Mahadevan D, Luke JJ, Laport G, Brody JD, Hernandez-Aya L, Bonomi P, Goldman JW, Berim L, Renouf DJ, Goodwin RA, Munneke B, Ho PY, Hsieh J, McCaffery I, Kwei L, Willingham SB, Miller RA.) Cancer Discov. 2020 Jan;10(1):40-53 PMID: 31732494 PMCID: PMC6954326 SCOPUS ID: 2-s2.0-85077761754 11/17/2019

• Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain.

  (Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G.) PLoS One. 2020;15(2):e0217452 PMID: 32027651 PMCID: PMC7004349 SCOPUS ID: 2-s2.0-85079081692 02/07/2020

• Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.

  (Santofimia-Castaño P, Xia Y, Peng L, Velázquez-Campoy A, Abián O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J.) Cells. 2019 11 17;8(11) PMID: 31744261 PMCID: PMC6912534 11/21/2019

• Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.

  (Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R.) Proteins. 2019 11;87(11):904-916 PMID: 31152607 PMCID: PMC6790107 SCOPUS ID: 2-s2.0-85067403924 06/04/2019

• Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer.

  (Haddad BR, Erickson A, Udhane V, LaViolette PS, Rone JD, Kallajoki MA, See WA, Rannikko A, Mirtti T, Nevalainen MT.) Cancer Epidemiol Biomarkers Prev. 2019 10;28(10):1642-1651 PMID: 31292140 PMCID: PMC6774884 SCOPUS ID: 2-s2.0-85072849403 07/12/2019

• Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells.

  (Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S.) Cancer Immunol Res. 2019 10;7(10):1647-1662 PMID: 31515257 SCOPUS ID: 2-s2.0-85072848720 09/14/2019

• Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.

  (Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T.) Sci Signal. 2019 09 03;12(597) PMID: 31481522 PMCID: PMC6996596 SCOPUS ID: 2-s2.0-85071736372 09/05/2019

• Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome.

  (Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S.) Nat Commun. 2019 09 02;10(1):3931 PMID: 31477722 PMCID: PMC6718415 SCOPUS ID: 2-s2.0-85071610251 09/04/2019

• Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

  (Lomberk G, Dusetti N, Iovanna J, Urrutia R.) Nat Commun. 2019 08 28;10(1):3875 PMID: 31462645 PMCID: PMC6713756 SCOPUS ID: 2-s2.0-85071625821 08/30/2019

• Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

  (Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA.) Cell Cycle. 2019 06;18(12):1407-1421 PMID: 31130069 PMCID: PMC6592258 SCOPUS ID: 2-s2.0-85067316375 05/28/2019

• Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators.

  (Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B.) Oncotarget. 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 06/14/2019

• CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

  (Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.) JCI Insight. 2019 May 16;5 PMID: 31095524 PMCID: PMC6629126 SCOPUS ID: 2-s2.0-85070659965 05/17/2019

• STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models.

  (Jing W, McAllister D, Vonderhaar EP, Palen K, Riese MJ, Gershan J, Johnson BD, Dwinell MB.) J Immunother Cancer. 2019 04 29;7(1):115 PMID: 31036082 PMCID: PMC6489306 SCOPUS ID: 2-s2.0-85065258266 05/01/2019

• Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.

  (Starenki D, Sosonkina N, Hong SK, Lloyd RV, Park JI.) Int J Mol Sci. 2019 Apr 26;20(9) PMID: 31027376 PMCID: PMC6540051 SCOPUS ID: 2-s2.0-85065295769 04/28/2019

• A Serum-Induced Transcriptome and Serum Cytokine Signature Obtained at Diagnosis Correlates with the Development of Early Pancreatic Ductal Adenocarcinoma Metastasis.

  (Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA.) Cancer Epidemiol Biomarkers Prev. 2019 04;28(4):680-689 PMID: 30530849 PMCID: PMC6545232 SCOPUS ID: 2-s2.0-85063867816 12/12/2018

• Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals.

  (Antholine WE, Vasquez-Vivar J, Quirk BJ, Whelan HT, Wu PK, Park JI, Myers CR.) Int J Mol Sci. 2019 Mar 06;20(5) PMID: 30845710 PMCID: PMC6429069 SCOPUS ID: 2-s2.0-85062628835 03/09/2019

• Effect of Donor Race-Matching on Overall Survival for African-American Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.

  (Silva JP, Maurina MN, Tsai S, Christians KK, Clarke CN, Mogal H, Saeian K, Gamblin TC.) J Am Coll Surg. 2019 03;228(3):245-254 PMID: 30639515 SCOPUS ID: 2-s2.0-85060157296 01/15/2019

• Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space.

  (McGarry SD, Bukowy JD, Iczkowski KA, Unteriner JG, Duvnjak P, Lowman AK, Jacobsohn K, Hohenwalter M, Griffin MO, Barrington AW, Foss HE, Keuter T, Hurrell SL, See WA, Nevalainen MT, Banerjee A, LaViolette PS.) Tomography. 2019 03;5(1):127-134 PMID: 30854450 PMCID: PMC6403022 SCOPUS ID: 2-s2.0-85071529534 03/12/2019

• Distal splenorenal and mesocaval shunting at the time of pancreatectomy.

  (Chavez MI, Tsai S, Clarke CN, Aldakkak M, Griffin MO, Khan AH, Ritch PS, Erickson BA, Evans DB, Christians KK.) Surgery. 2019 02;165(2):298-306 PMID: 30471779 SCOPUS ID: 2-s2.0-85056892124 11/26/2018

• Outcomes of Elderly Patients Undergoing Curative Resection for Retroperitoneal Sarcomas: Analysis From the US Sarcoma Collaborative.

  (Wilkinson KH, Ethun CG, Hembrook M, Bedi M, Charlson J, Mogal H, Tsai S, Christians K, Tran TB, Poultsides G, Grignol V, Howard JH, Tseng J, Roggin KK, Chouliaras K, Votanopoulos K, Cullinan D, Fields RC, Weber S, Gamblin TC, Cardona K, Clarke CN.) J Surg Res. 2019 01;233:154-162 PMID: 30502242 SCOPUS ID: 2-s2.0-85051762456 12/07/2018

• Elective Regional Therapy Treatment for Hepatic Adenoma.

  (Silva JP, Klooster B, Tsai S, Christians KK, Clarke CN, Mogal H, Clark Gamblin T.) Ann Surg Oncol. 2019 Jan;26(1):125-130 PMID: 30353390 SCOPUS ID: 2-s2.0-85055702464 10/26/2018

• Beyond the cell surface: Targeting intracellular negative regulators to enhance t cell anti-tumor activity

  (Sitaram P, Uyemura B, Malarkannan S, Riese MJ.) International Journal of Molecular Sciences. 1 December 2019;20(23) SCOPUS ID: 2-s2.0-85075296555 12/01/2019

• Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia.

  (Minieri V, De Dominici M, Nevalainen MT, Calabretta B.) Oncotarget. 2018 Dec 04;9(95):36726-36727 PMID: 30613358 PMCID: PMC6298402 01/08/2019

• Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia.

  (Minieri V, De Dominici M, Porazzi P, Mariani SA, Spinelli O, Rambaldi A, Peterson LF, Porcu P, Nevalainen MT, Calabretta B.) Cancer Res. 2018 10 15;78(20):5793-5807 PMID: 30154155 PMCID: PMC7100125 SCOPUS ID: 2-s2.0-85054889112 08/30/2018

• Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation.

  (Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB.) J Biol Chem. 2018 09 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 SCOPUS ID: 2-s2.0-85054023214 08/09/2018

• Radio-pathomic Maps of Epithelium and Lumen Density Predict the Location of High-Grade Prostate Cancer.

  (McGarry SD, Hurrell SL, Iczkowski KA, Hall W, Kaczmarowski AL, Banerjee A, Keuter T, Jacobsohn K, Bukowy JD, Nevalainen MT, Hohenwalter MD, See WA, LaViolette PS.) Int J Radiat Oncol Biol Phys. 2018 08 01;101(5):1179-1187 PMID: 29908785 PMCID: PMC6190585 SCOPUS ID: 2-s2.0-85048748761 06/18/2018

• A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses.

  (Hong SK, Wu PK, Park JI.) Cell Signal. 2018 Jan;42:11-20 PMID: 28986121 PMCID: PMC5732048 SCOPUS ID: 2-s2.0-85031106212 10/08/2017

• Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.

  (Wu PK, Hong SK, Park JI.) Mol Cell Biol. 2017 Sep 15;37(18) PMID: 28674184 PMCID: PMC5574043 SCOPUS ID: 2-s2.0-85028363255 07/05/2017