Recent Publications

• Variant anatomy of the biliary system as a cause of pancreatic and peri-ampullary cancers.

  (Muraki T, Reid MD, Pehlivanoglu B, Gonzalez RS, Sekhar A, Memis B, Xue Y, Cheng J, Jang KT, Mittal P, Cardona K, Kooby DA, Maithel S, Sarmiento JM, El-Rayes B, Lomberk G, Urrutia RA, Christians K, Tsai S, Evans DB, Adsay V.) HPB (Oxford). 2020 Dec;22(12):1675-1685 PMID: 32336556 SCOPUS ID: 2-s2.0-85083637358 04/28/2020

• Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer.

  (Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG.) FASEB J. 2020 Dec;34(12):16034-16048 PMID: 33047385 SCOPUS ID: 2-s2.0-85092336914 10/14/2020

• Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Results of the NCI-MATCH Trial Subprotocol H.

  (Salama AKS, Li S, Macrae ER, Park JI, Mitchell EP, Zwiebel JA, Chen HX, Gray RJ, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Armstrong DK, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT.) J Clin Oncol. 2020 Nov 20;38(33):3895-3904 PMID: 32758030 PMCID: PMC7676884 08/08/2020

• Cytokines, JAK-STAT Signaling and Radiation-Induced DNA Repair in Solid Tumors: Novel Opportunities for Radiation Therapy.

  (Hall WA, Sabharwal L, Udhane V, Maranto C, Nevalainen MT.) Int J Biochem Cell Biol. 2020 Oct;127:105827 PMID: 32822847 SCOPUS ID: 2-s2.0-85090734995 08/22/2020

• The Promise of Circulating Tumor DNA (ctDNA) in the Management of Early-Stage Colon Cancer: A Critical Review.

  (Chakrabarti S, Xie H, Urrutia R, Mahipal A.) Cancers (Basel). 2020 09 29;12(10) PMID: 33003583 PMCID: PMC7601010 10/03/2020

• Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells.

  (Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B.) Cancer Treat Res Commun. 2020 Sep 17;25:100210 PMID: 32987287 SCOPUS ID: 2-s2.0-85091576205 09/29/2020

• ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

  (Lan W, Santofimia-Castaño P, Swayden M, Xia Y, Zhou Z, Audebert S, Camoin L, Huang C, Peng L, Jiménez-Alesanco A, Velázquez-Campoy A, Abián O, Lomberk G, Urrutia R, Rizzuti B, Geli V, Soubeyran P, Neira JL, Iovanna J.) JCI Insight. 2020 Sep 17;5(18) PMID: 32780723 PMCID: PMC7526551 SCOPUS ID: 2-s2.0-85090785767 08/12/2020

• Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network.

  (Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):057501 PMID: 33062803 PMCID: PMC7550797 10/17/2020

• Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base.

  (Liu C, Rein L, Clarke C, Mogal H, Tsai S, Christians KK, Gamblin TC.) J Surg Oncol. 2020 Aug;122(2):176-182 PMID: 32383268 SCOPUS ID: 2-s2.0-85085151262 05/10/2020

• Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats.

  (Kim J, Hagen CE, Kumar SN, Park JI, Zimmerman MA, Hong JC.) Transplant Direct. 2020 Aug;6(8):e584 PMID: 32766432 PMCID: PMC7371100 08/09/2020

• Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway.

  (Wu PK, Becker A, Park JI.) Int J Mol Sci. 2020 Jul 30;21(15) PMID: 32751750 PMCID: PMC7432891 SCOPUS ID: 2-s2.0-85089131301 08/06/2020

• Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells.

  (Che M, Kweon SM, Teo JL, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY.) Cancers (Basel). 2020 Jun 05;12(6) PMID: 32516943 PMCID: PMC7352534 06/11/2020

• Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment

  (Sharick JT, Walsh CM, Sprackling CM, Pasch CA, Pham DL, Esbona K, Choudhary A, Garcia-Valera R, Burkard ME, McGregor SM, Matkowskyj KA, Parikh AA, Meszoely IM, Kelley MC, Tsai S, Deming DA, Skala MC.) Frontiers in Oncology. 15 May 2020;10 SCOPUS ID: 2-s2.0-85085504111 05/15/2020

• Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

  (Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S.) Elife. 2020 May 14;9 PMID: 32406817 PMCID: PMC7255804 SCOPUS ID: 2-s2.0-85085630468 05/15/2020

• Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.

  (Wu PK, Hong SK, Starenki D, Oshima K, Shao H, Gestwicki JE, Tsai S, Park JI.) Oncogene. 2020 05;39(21):4257-4270 PMID: 32291414 PMCID: PMC7244387 SCOPUS ID: 2-s2.0-85083767959 04/16/2020

• Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21.

  (Moussouras NA, Hjortø GM, Peterson FC, Szpakowska M, Chevigné A, Rosenkilde MM, Volkman BF, Dwinell MB.) Biochemistry. 2020 04 07;59(13):1338-1350 PMID: 32182428 PMCID: PMC7307649 SCOPUS ID: 2-s2.0-85083041593 03/18/2020

• Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.

  (Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI.) Sci Signal. 2020 Mar 10;13(622) PMID: 32156782 PMCID: PMC7099430 SCOPUS ID: 2-s2.0-85081677231 03/12/2020

• Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse.

  (Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G.) Mol Cancer Res. 2020 03;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019

• Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.

  (Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 02 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019

• Salvage ipilimumab associated with a significant response in sarcomatoid renal cell carcinoma.

  (George G, Schmidt L, Tolat P, Riese M, Kilari D.) J Immunother Cancer. 2020 02;8(1) PMID: 32114501 PMCID: PMC7057424 SCOPUS ID: 2-s2.0-85080840435 03/03/2020

• Gross tumor size using the AJCC 8th ed. T staging criteria does not provide prognostic stratification for neoadjuvant treated pancreatic ductal adenocarcinoma

  (Rowan DJ, Hartley CP, Aldakkak M, Christians KK, Evans DB, Tsai S, Hagen CE.) Annals of Diagnostic Pathology. June 2020;46 SCOPUS ID: 2-s2.0-85081260042 06/01/2020

• Value of Pretreatment 18F-fluorodeoxyglucose Positron Emission Tomography in Patients With Localized Pancreatic Cancer Treated With Neoadjuvant Therapy.

  (Barnes CA, Aldakkak M, Clarke CN, Christians KK, Bucklan D, Holt M, Tolat P, Ritch PS, George B, Hall WA, Erickson BA, Evans DB, Tsai S.) Front Oncol. 2020;10:500 PMID: 32363161 PMCID: PMC7180175 SCOPUS ID: 2-s2.0-85084152103 05/05/2020

• Impact of Neoadjuvant Chemoradiation on Pathologic Response in Patients With Localized Pancreatic Cancer.

  (Wittmann D, Hall WA, Christians KK, Barnes CA, Jariwalla NR, Aldakkak M, Clarke CN, George B, Ritch PS, Riese M, Khan AH, Kulkarni N, Evans J, Erickson BA, Evans DB, Tsai S.) Front Oncol. 2020;10:460 PMID: 32351886 PMCID: PMC7175033 SCOPUS ID: 2-s2.0-85084010622 05/01/2020

• Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain.

  (Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G.) PLoS One. 2020;15(2):e0217452 PMID: 32027651 PMCID: PMC7004349 SCOPUS ID: 2-s2.0-85079081692 02/07/2020

• Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors.

  (Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, See WA, Mirtti T, Kilari D, Nevalainen MT.) Mol Cancer Ther. 2020 01;19(1):231-246 PMID: 31548294 PMCID: PMC6946850 SCOPUS ID: 2-s2.0-85077669370 09/25/2019

• Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells

  (Gerbec ZJ, Hashemi E, Nanbakhsh A, Holzhauer S, Yang C, Mei A, Tsaih SW, Lemke A, Flister MJ, Riese MJ, Thakar MS, Malarkannan S.) iScience. 25 September 2020;23(9) SCOPUS ID: 2-s2.0-85089821937 09/25/2020

• Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity.

  (Sitaram P, Uyemura B, Malarkannan S, Riese MJ.) Int J Mol Sci. 2019 Nov 20;20(23) PMID: 31756921 PMCID: PMC6929154 SCOPUS ID: 2-s2.0-85075296555 11/24/2019

• Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.

  (Santofimia-Castaño P, Xia Y, Peng L, Velázquez-Campoy A, Abián O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J.) Cells. 2019 11 17;8(11) PMID: 31744261 PMCID: PMC6912534 SCOPUS ID: 2-s2.0-85082729502 11/21/2019

• Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer.

  (Haddad BR, Erickson A, Udhane V, LaViolette PS, Rone JD, Kallajoki MA, See WA, Rannikko A, Mirtti T, Nevalainen MT.) Cancer Epidemiol Biomarkers Prev. 2019 10;28(10):1642-1651 PMID: 31292140 PMCID: PMC6774884 SCOPUS ID: 2-s2.0-85072849403 07/12/2019

• Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

  (Lomberk G, Dusetti N, Iovanna J, Urrutia R.) Nat Commun. 2019 08 28;10(1):3875 PMID: 31462645 PMCID: PMC6713756 SCOPUS ID: 2-s2.0-85071625821 08/30/2019

• Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators.

  (Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B.) Oncotarget. 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 06/14/2019

• STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models.

  (Jing W, McAllister D, Vonderhaar EP, Palen K, Riese MJ, Gershan J, Johnson BD, Dwinell MB.) J Immunother Cancer. 2019 04 29;7(1):115 PMID: 31036082 PMCID: PMC6489306 SCOPUS ID: 2-s2.0-85065258266 05/01/2019

• Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.

  (Starenki D, Sosonkina N, Hong SK, Lloyd RV, Park JI.) Int J Mol Sci. 2019 Apr 26;20(9) PMID: 31027376 PMCID: PMC6540051 SCOPUS ID: 2-s2.0-85065295769 04/28/2019

• A Serum-Induced Transcriptome and Serum Cytokine Signature Obtained at Diagnosis Correlates with the Development of Early Pancreatic Ductal Adenocarcinoma Metastasis.

  (Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA.) Cancer Epidemiol Biomarkers Prev. 2019 04;28(4):680-689 PMID: 30530849 PMCID: PMC6545232 SCOPUS ID: 2-s2.0-85063867816 12/12/2018

• Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space.

  (McGarry SD, Bukowy JD, Iczkowski KA, Unteriner JG, Duvnjak P, Lowman AK, Jacobsohn K, Hohenwalter M, Griffin MO, Barrington AW, Foss HE, Keuter T, Hurrell SL, See WA, Nevalainen MT, Banerjee A, LaViolette PS.) Tomography. 2019 03;5(1):127-134 PMID: 30854450 PMCID: PMC6403022 SCOPUS ID: 2-s2.0-85071529534 03/12/2019

• Beyond the cell surface: Targeting intracellular negative regulators to enhance t cell anti-tumor activity

  (Sitaram P, Uyemura B, Malarkannan S, Riese MJ.) International Journal of Molecular Sciences. 1 December 2019;20(23) SCOPUS ID: 2-s2.0-85075296555 12/01/2019

• Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia.

  (Minieri V, De Dominici M, Nevalainen MT, Calabretta B.) Oncotarget. 2018 Dec 04;9(95):36726-36727 PMID: 30613358 PMCID: PMC6298402 01/08/2019