Recent Publications from the Zablocki VA Medical Center Research Laboratories

Validation and application of a finite element model simulating failure thresholds of skin during blunt puncture with varying impactor geometries.

(LeSueur J, Hampton CE, Pintar FA.) J Mech Behav Biomed Mater. 2025 Aug;168:107035 PMID: 40318470 05/04/2025

Impactor Displacement as a Predictor of Thoraco-Abdominal Organ Injury: Comparison of Isolated Organ to Whole Body Tests.

(Seifert J, Koser J, Shah A, Frazer L, Pintar FA, Yoganandan N, Nicolella D, Bentley TB, Stemper BD.) Ann Biomed Eng. 2025 Jul 14 PMID: 40658298 07/14/2025

Neuroimaging Characterization of Acute Traumatic Brain Injury with Focus on Frontline Clinicians: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Imaging Working Group.

(Mac Donald CL, Yuh EL, Vande Vyvere T, Edlow BL, Li LM, Mayer AR, Mukherjee P, Newcombe VFJ, Wilde EA, Koerte IK, Yurgelun-Todd D, Wu YC, Duhaime AC, Awwad HO, Dams-O'Connor K, Doperalski A, Maas AIR, McCrea MA, Umoh N, Manley GT.) J Neurotrauma. 2025 Jul;42(13-14):1056-1064 PMID: 40393517 SCOPUS ID: 2-s2.0-105006472764 05/21/2025

Blood-Based Biomarkers for Improved Characterization of Traumatic Brain Injury: Recommendations from the 2024 National Institute for Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Blood-Based Biomarkers Working Group.

(Bazarian JJ, Zetterberg H, Buki A, Dengler BA, Diaz-Arrastia R, Korley FK, Lazarus R, Meier TB, Mondello S, Moritz K, Okonkwo DO, Papa L, Phillips JB, Posti JP, Puccio AM, Sloley S, Steyerberg E, Wang KK, Awwad HO, Dams-O'Connor K, Doperalski A, Maas AIR, McCrea MA, Umoh N, Manley GT.) J Neurotrauma. 2025 Jul;42(13-14):1065-1085 PMID: 40393505 SCOPUS ID: 2-s2.0-105006897418 05/21/2025

Clinical Assessment on Days 1-14 for the Characterization of Traumatic Brain Injury: Recommendations from the 2024 NINDS Traumatic Brain Injury Classification and Nomenclature Initiative Clinical/Symptoms Working Group.

(Menon DK, Silverberg ND, Ferguson AR, Bayuk TJ, Bhattacharyay S, Brody DL, Cota SA, Ercole A, Figaji A, Gao G, Giza CC, Lecky F, Mannix R, Mikolić A, Moritz KE, Robertson CS, Torres-Espin A, Tsetsou S, Yue JK, Awad HO, Dams-O'Connor K, Doperalski A, Maas AIR, McCrea MA, Umoh N, Manley GT.) J Neurotrauma. 2025 Jul;42(13-14):1038-1055 PMID: 40393504 SCOPUS ID: 2-s2.0-105006897468 05/21/2025

Labeling phrenic afferents with intrapleural AAV-PHP.S.

(Morales AC, Holmes TC, Sanchez FT, Huang H, Williams JJ, Streeter KA.) J Neurosci Methods. 2025 Jul;419:110466 PMID: 40334752 PMCID: PMC12147650 05/08/2025

Distinct symptom recoveries based upon highest level of care in patients with sport-related concussion or traumatic brain injury and Glasgow Coma Scale 13-15.

(Eagle SR, Lamb B, Huber D, McCrea MA, Tarima S, deRoon-Cassini TA, Okonkwo DO, Nelson LD.) Clin Neurol Neurosurg. 2025 Jun 16;256:109017 PMID: 40532286 SCOPUS ID: 2-s2.0-105008205601 06/19/2025

Flight-associated cortisol dynamics and subjective assessments of pain and stress in fighter pilots: an exploratory study.

(Raff H, Hainsworth KR, Cutlan R, Sherman KA, Stemper BD.) Eur J Appl Physiol. 2025 Jun 13 PMID: 40512180 06/13/2025

AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy.

(Fehlings MG, Evaniew N, Ter Wengel PV, Vedantam A, Guha D, Margetis K, Nouri A, Ahmed AI, Neal CJ, Davies BM, Ganau M, Wilson JR, Martin AR, Grassner L, Tetreault L, Rahimi-Movaghar V, Marco R, Harrop J, Guest J, Alvi MA, Pedro KM, Kwon BK, Fisher CG, Kurpad SN, AO Spine Knowledge Forum Spinal Cord Injury.) Global Spine J. 2025 Jun;15(5):2585-2593 PMID: 40257837 PMCID: PMC12012498 SCOPUS ID: 2-s2.0-105004277039 04/21/2025

The Histological and Mechanical Behavior of Skin During Puncture for Different Impactor Sizes and Loading Rates.

(LeSueur J, Koser J, Dzwierzynski W, Stemper BD, Hampton CE, Kleinberger M, Pintar FA.) Ann Biomed Eng. 2025 May;53(5):1209-1225 PMID: 40053222 SCOPUS ID: 2-s2.0-86000310645 03/07/2025

In Reply: AO Spine & Praxis Spinal Cord Institute Clinical Practice Guidelines for the Management of Acute Spinal Cord Injury.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) Neurosurgery. 2025 Mar 01;96(3):e61-e63 PMID: 39853094 SCOPUS ID: 2-s2.0-85216566942 01/24/2025

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

(Santini T, Shim A, Liou JJ, Rahman N, Varela-Mattatall G, Budde MD, Inoue W, Everling S, Baron CA.) Magn Reson Med. 2025 Feb;93(2):788-802 PMID: 39323069 PMCID: PMC11604852 SCOPUS ID: 2-s2.0-85205058687 09/26/2024

Editorial. The AO Spine/Praxis Spinal Cord Institute clinical practice guidelines for acute spinal cord injury: interpretation and implications for clinical practice.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) J Neurosurg Spine. 2025 Jan 24;42(4):526-529 PMID: 39854702 SCOPUS ID: 2-s2.0-105001864128 01/24/2025

Patient Experiences of and Priorities for Traumatic Brain Injury Health Care in a US Level 1 Trauma Center: A Qualitative Study

(Nelson LD, Gray S, Barry CO, Young SA, deRoon-Cassini TA, Hedayat H, Kobayashi Y, McCrea MA, Tobes N, Trevino CM, Williams KS.) Mayo Clinic Proceedings Innovations Quality and Outcomes. August 2025;9(4) SCOPUS ID: 2-s2.0-105007887754 08/01/2025

A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative

(Manley GT, Dams-O'Connor K, Alosco ML, Awwad HO, Bazarian JJ, Bragge P, Corrigan JD, Doperalski A, Ferguson AR, Mac Donald CL, Menon DK, McNett MM, van der Naalt J, Nelson LD, Pisică D, Silverberg ND, Umoh N, Wilson L, Yuh EL, Zetterberg H, Maas AIR, McCrea MA.) Lancet Neurology. June 2025;24(6):512-523 SCOPUS ID: 2-s2.0-105005509105 06/01/2025

Mechanical Characterization of Non-degraded Porcine Annulus Fibrosus Material Properties.

(Seifert J, Maiman D, Frazer LL, Shah A, Yoganandan N, King K, Sheehy JB, Paskoff G, Bentley T, Nicolella DP, Stemper BD.) Ann Biomed Eng. 2024 Nov 05 PMID: 39499364 SCOPUS ID: 2-s2.0-85208479174 11/05/2024

Subclinical brain manifestations of repeated mild traumatic brain injury are changed by chronic exposure to sleep loss, caffeine, and sleep aids.

(Everson CA, Szabo A, Plyer C, Hammeke TA, Stemper BD, Budde MD.) Exp Neurol. 2024 Nov;381:114928 PMID: 39168169 SCOPUS ID: 2-s2.0-85201764724 08/22/2024

Expanded Combined Loading Injury Criterion for the Human Lumbar Spine Under Dynamic Compression.

(Ortiz-Paparoni M, Op 't Eynde J, Eckersley C, Morino C, Abrams M, Pang D, Kait J, Pintar F, Yoganandan N, Moore J, Barnes D, Loftis K, Bass CR.) Ann Biomed Eng. 2024 Nov;52(11):3067-3077 PMID: 39240473 SCOPUS ID: 2-s2.0-85203121909 09/06/2024

Evaluation of synthetic clear gelatin as an acceptable surrogate for low-velocity penetrating impacts using the depth of penetration calibration standard.

(LeSueur J, Koser J, Hargarten S, Pintar FA.) J Mech Behav Biomed Mater. 2024 Nov;159:106710 PMID: 39216336 SCOPUS ID: 2-s2.0-85202354471 09/01/2024

Lumbar Spine Orientation Affects Compressive Fracture Outcome.

(Cutlan R, Khokhar M, Shammout N, Shah AS, Frazer L, Yoganandan N, Shender BS, Sheehy J, Paskoff G, Nicolella D, Bentley T, Shabani S, Stemper BD.) Ann Biomed Eng. 2024 Oct 25 PMID: 39453511 10/25/2024

Effect of sagittal alignment on spinal cord biomechanics in the stenotic cervical spine during neck flexion and extension.

(Gundamraj S, Devaraj KB, Harinathan B, Banerjee A, Yoganandan N, Vedantam A.) Biomech Model Mechanobiol. 2024 Oct;23(5):1757-1764 PMID: 39003653 SCOPUS ID: 2-s2.0-85198355255 07/14/2024

Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization.

(Koch KM, Nencka AS, Kurpad S, Budde MD.) J Neurotrauma. 2024 Sep;41(17-18):2125-2132 PMID: 38251658 PMCID: PMC12056579 SCOPUS ID: 2-s2.0-85190264996 01/22/2024

Behind Armor Blunt Trauma: Liver Injuries Using a Live Animal Model.

(Yoganandan N, Shah A, Koser J, Stemper BD, Somberg L, Chancey VC, McEntire J.) Mil Med. 2024 Aug 19;189(Suppl 3):659-664 PMID: 39160873 SCOPUS ID: 2-s2.0-85201736818 08/20/2024

Is Posterior Cervical Foraminotomy Better Than Fusion for Warfighters?: A Biomechanical Study.

(Choi H, Purushothaman Y, Ozobu I, Yoganandan N.) Mil Med. 2024 Aug 19;189(Suppl 3):710-718 PMID: 39160815 SCOPUS ID: 2-s2.0-85201744350 08/20/2024

Hybrid III Manikin Lumbar Spine Loading Under Vertical Impact.

(Yoganandan N, Moore J, Westerhof TA, Flierman NA.) Mil Med. 2024 Aug 19;189(Suppl 3):55-62 PMID: 39160828 SCOPUS ID: 2-s2.0-85201737711 08/20/2024

A minimum data set-Core outcome set, core data elements, and core measurement set-For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study.

(Davies BM, Yang X, Khan DZ, Mowforth OD, Touzet AY, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Blizzard T, Treanor C, Anderson D, Fallah N, Hazenbiller O, Salzman C, Zimmerman Z, Wandycz AM, Widdop S, Reeves M, Raine R, Ryan SK, Malone A, Gharooni A, Wilson JR, Martin AR, Fehlings MG, McNair AGK, Kotter MRN, AO SPINE RECODE-DCM Steering Committee and AO Spine RECODE DCM Community.) PLoS Med. 2024 Aug;21(8):e1004447 PMID: 39173109 PMCID: PMC11379399 SCOPUS ID: 2-s2.0-85201785269 08/22/2024

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation.

(Moravec EM, Williams JJ.) Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul;2024:1-5 PMID: 40039756 SCOPUS ID: 2-s2.0-85214968946 03/05/2025

Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury.

(Ryan F, Blex C, Ngo TD, Kopp MA, Michalke B, Venkataramani V, Curran L, Schwab JM, Ruprecht K, Otto C, Jhelum P, Kroner A, David S.) Acta Neuropathol. 2024 Jun 22;147(1):106 PMID: 38907771 PMCID: PMC11193702 06/22/2024

Cervical spinal cord angiography and vessel-selective perfusion imaging in the rat.

(Lee S, Schmit BD, Kurpad SN, Budde MD.) NMR Biomed. 2024 Jun;37(6):e5115 PMID: 38355219 PMCID: PMC11078600 SCOPUS ID: 2-s2.0-85185526294 02/15/2024

A guiding light for stimulating paralyzed muscles.

(Williams J.) Sci Robot. 2024 May 22;9(90):eado9987 PMID: 38776376 SCOPUS ID: 2-s2.0-85194016732 05/22/2024

Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

(Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak AV, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers JM, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Laganà MM, Laule C, Law CSW, Leutritz T, Liu Y, Llufriu S, Mackey S, Martin AR, Martinez-Heras E, Mattera L, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley GW, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J, Cohen-Adad J, Lenglet C, Nestrašil I.) bioRxiv. 2024 May 01 PMID: 38746371 PMCID: PMC11092490 05/15/2024

An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery.

(Fehlings MG, Tetreault LA, Hachem L, Evaniew N, Ganau M, McKenna SL, Neal CJ, Nagoshi N, Rahimi-Movaghar V, Aarabi B, Hofstetter CP, Wengel VT, Nakashima H, Martin AR, Kirshblum S, Rodrigues Pinto R, Marco RAW, Wilson JR, Kahn DE, Newcombe VFJ, Zipser CM, Douglas S, Kurpad SN, Lu Y, Saigal R, Samadani U, Arnold PM, Hawryluk GWJ, Skelly AC, Kwon BK.) Global Spine J. 2024 Mar;14(3_suppl):174S-186S PMID: 38526922 PMCID: PMC10964895 03/25/2024

Tensor-valued diffusion MRI of human acute stroke

(.) Magnetic Resonance in Medicine. May 2024;91(5):2126-2141 SCOPUS ID: 2-s2.0-85181197209 05/01/2024

We Choose to Call it ‘Degenerative Cervical Myelopathy’: Findings of AO Spine RECODE-DCM, an International and Multi-Stakeholder Partnership to Agree a Standard Unifying Term and Definition for a Disease

(Davies BM, Khan DZ, Barzangi K, Ali A, Mowforth OD, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Widdop S, Fehlings MG, Kotter MRN.) Global Spine Journal. March 2024;14(2):503-512 SCOPUS ID: 2-s2.0-85133336136 03/01/2024

Visualizing and quantifying the energy of bullets: Does it matter clinically?

(LeSueur J, Pintar FA, Hargarten S.) Visual Journal of Emergency Medicine. October 2024;37 SCOPUS ID: 2-s2.0-85203456150 10/01/2024

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation

(Moravec EM, Williams JJ.) Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS. 2024 SCOPUS ID: 2-s2.0-85214968946 01/01/2024

Using Finite Element Models to Assess Spinal Cord Biomechanics after Cervical Laminoplasty for Degenerative Cervical Myelopathy

(Rahman M, Palmer P, Harinathan B, Banurekha Devaraj K, Yoganandan N, Vedantam A.) Diagnostics. July 2024;14(14) SCOPUS ID: 2-s2.0-85199590245 07/01/2024

Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice.

(St-Pierre MK, González Ibáñez F, Kroner A, Tremblay MÈ.) J Neuroinflammation. 2023 Nov 21;20(1):273 PMID: 37990235 PMCID: PMC10664529 11/22/2023

Ferroptosis in Neurological Disease.

(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022

Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.

(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023

IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.

(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders.

(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2

(Williams JJ, Vazquez AL, Schwartz AB.) International IEEE EMBS Conference on Neural Engineering Ner. 16 May 2019;2019-March:534-537 SCOPUS ID: 2-s2.0-85066753496 05/16/2019

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.

(Williams JJ, Watson AM, Vazquez AL, Schwartz AB.) Front Neurosci. 2019;13:759 PMID: 31417342 PMCID: PMC6684788 08/17/2019