Recent Publications from the Zablocki VA Medical Center Research Laboratories

Tensor-valued diffusion MRI of human acute stroke.

(Zhou M, Stobbe R, Szczepankiewicz F, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Nilsson M, Westin CF, Beaulieu C.) Magn Reson Med. 2024 May;91(5):2126-2141 PMID: 38156813 SCOPUS ID: 2-s2.0-85181197209 01/02/2024

Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization.

(Koch KM, Nencka AS, Kurpad S, Budde MD.) J Neurotrauma. 2024 Apr 10 PMID: 38251658 SCOPUS ID: 2-s2.0-85190264996 01/22/2024

Subject-Specific Geometry of FE Lumbar Spine Models for the Replication of Fracture Locations Using Dynamic Drop Tests.

(Rieger LK, Shah A, Schick S, Draper DB, Cutlan R, Peldschus S, Stemper BD.) Ann Biomed Eng. 2024 Apr;52(4):816-831 PMID: 38374520 SCOPUS ID: 2-s2.0-85185246806 02/20/2024

An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery.

(Fehlings MG, Tetreault LA, Hachem L, Evaniew N, Ganau M, McKenna SL, Neal CJ, Nagoshi N, Rahimi-Movaghar V, Aarabi B, Hofstetter CP, Wengel VT, Nakashima H, Martin AR, Kirshblum S, Rodrigues Pinto R, Marco RAW, Wilson JR, Kahn DE, Newcombe VFJ, Zipser CM, Douglas S, Kurpad SN, Lu Y, Saigal R, Samadani U, Arnold PM, Hawryluk GWJ, Skelly AC, Kwon BK.) Global Spine J. 2024 Mar;14(3_suppl):174S-186S PMID: 38526922 PMCID: PMC10964895 03/25/2024

Optimizing Concussion Care Seeking: Connecting Care-Seeking Behaviors and Neurophysiological States Through Blood Biomarkers.

(D'Lauro C, Register-Mihalik JK, Meier TB, Kerr ZY, Knight K, Broglio SP, Leeds D, Lynall RC, Kroshus E, McCrea MA, McAllister TW, Schmidt JD, CARE Consortium Investigators:, Master C, McGinty G, Jackson JC, Cameron KL, Buckley T, Kaminski T, Mihalik JP.) Am J Sports Med. 2024 Mar;52(3):801-810 PMID: 38340366 SCOPUS ID: 2-s2.0-85185104883 02/10/2024

Cervical spinal cord angiography and vessel-selective perfusion imaging in the rat.

(Lee S, Schmit BD, Kurpad SN, Budde MD.) NMR Biomed. 2024 Feb 14:e5115 PMID: 38355219 SCOPUS ID: 2-s2.0-85185526294 02/15/2024

Sleep loss, caffeine, sleep aids and sedation modify brain abnormalities of mild traumatic brain injury.

(Everson CA, Szabo A, Plyer C, Hammeke TA, Stemper BD, Budde MD.) Exp Neurol. 2024 Feb;372:114620 PMID: 38029810 SCOPUS ID: 2-s2.0-85179070318 11/30/2023

Association of Blood Biomarkers of Inflammation With Acute Concussion in Collegiate Athletes and Military Service Academy Cadets.

(Meier TB, Huber DL, Goeckner BD, Gill JM, Pasquina P, Broglio SP, McAllister TW, Harezlak J, McCrea MA, for CARE Consortium Investigators.) Neurology. 2024 Jan 23;102(2):e207991 PMID: 38165315 SCOPUS ID: 2-s2.0-85181764488 01/02/2024

Tensor-valued diffusion MRI of human acute stroke

(Zhou M, Stobbe R, Szczepankiewicz F, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Nilsson M, Westin CF, Beaulieu C.) Magnetic Resonance in Medicine. May 2024;91(5):2126-2141 SCOPUS ID: 2-s2.0-85181197209 05/01/2024

We Choose to Call it ‘Degenerative Cervical Myelopathy’: Findings of AO Spine RECODE-DCM, an International and Multi-Stakeholder Partnership to Agree a Standard Unifying Term and Definition for a Disease

(Davies BM, Khan DZ, Barzangi K, Ali A, Mowforth OD, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Widdop S, Fehlings MG, Kotter MRN.) Global Spine Journal. March 2024;14(2):503-512 SCOPUS ID: 2-s2.0-85133336136 03/01/2024

A Practical Classification System for Acute Cervical Spinal Cord Injury Based on a Three-Phased Modified Delphi Process From the AOSpine Spinal Cord Injury Knowledge Forum

(Hachem LD, Zhu M, Aarabi B, Davies B, DiGiorgio A, Evaniew N, Fehlings MG, Ganau M, Graves D, Guest J, Ha Y, Harrop J, Hofstetter C, Koljonen P, Kurpad S, Marco R, Martin AR, Nagoshi N, Nouri A, Rahimi-Movaghar V, Rodrigues-Pinto R, Wengel Vt, Tetreault L, Kwon B, Wilson JR.) Global Spine Journal. March 2024;14(2):535-545 SCOPUS ID: 2-s2.0-85138317004 03/01/2024

Profile of brief symptom inventory-18 (BSI-18) scores in collegiate athletes: A CARE Consortium study

(McAllister TW, Kenny R, Harezlak J, Harland J, McCrea MA, Pasquina P, Broglio SP.) Clinical Neuropsychologist. 2024 SCOPUS ID: 2-s2.0-85185668495 01/01/2024

Factors Influencing Time to Return to Learn Among NCAA Student-Athletes Enrolled in the Concussion Assessment, Research, and Education (CARE) Study

(Memmini AK, Snedden TR, Boltz AJ, Benson BA, Margolin E, Pasquina PF, McAllister TW, McCrea MA, Broglio SP.) Sports Medicine. 2024 SCOPUS ID: 2-s2.0-85185943043 01/01/2024

Sex-related disparities in vehicle crash injury and hemodynamics.

(Cronn S, Somasundaram K, Driesslein K, Tomas CW, Pintar F.) Front Public Health. 2024;12:1331313 PMID: 38560436 PMCID: PMC10978633 SCOPUS ID: 2-s2.0-85188905781 04/01/2024

Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study.

(Bryant AM, Rose NB, Temkin NR, Barber JK, Manley GT, McCrea MA, Nelson LD, TRACK-TBI Investigators, Badjatia N, Gopinath S, Keene CD, Madden C, Ngwenya LB, Puccio A, Robertson C, Schnyer D, Taylor SR, Yue JK.) JAMA Netw Open. 2023 Dec 01;6(12):e2349118 PMID: 38147333 PMCID: PMC10751593 SCOPUS ID: 2-s2.0-85181038532 12/26/2023

Analysis of experimental injuries to obese occupants with different postures in frontal impact.

(Yoganandan N, Somasundaram K, Pintar F.) Accid Anal Prev. 2023 Dec;193:107294 PMID: 37722257 SCOPUS ID: 2-s2.0-85171782373 09/19/2023

Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice.

(St-Pierre MK, González Ibáñez F, Kroner A, Tremblay MÈ.) J Neuroinflammation. 2023 Nov 21;20(1):273 PMID: 37990235 PMCID: PMC10664529 11/22/2023

Pelvis-Sacrum-Lumbar Spine Injury Characteristics From Underbody Blast Loading.

(Yoganandan N, Baisden J, Moore J, Pintar F, Vedantam A, Shabani S, Barnes D, Loftis K.) Mil Med. 2023 Nov 08;188(Suppl 6):393-399 PMID: 37948210 SCOPUS ID: 2-s2.0-85176449424 11/10/2023

A Novel Paradigm to Develop Regional Thoracoabdominal Criteria for Behind Armor Blunt Trauma Based on Original Data.

(Yoganandan N, Shah A, Somberg L, Baisden J, Stemper BD, Bass C, Salzar RS, Chancey VC, McEntire J.) Mil Med. 2023 Nov 08;188(Suppl 6):598-605 PMID: 37948200 SCOPUS ID: 2-s2.0-85176432947 11/10/2023

Preliminary Data of Neck Muscle Morphology With Head-Supported Mass in Male and Female Volunteers.

(Yoganandan N, Baisden J, Varghese V, Vedantam A, Stemper B, Banerjee A, Jebaseelan D.) Mil Med. 2023 Nov 08;188(Suppl 6):385-392 PMID: 37948211 SCOPUS ID: 2-s2.0-85176389139 11/10/2023

Subaxial Cervical Spine Motion With Different Sizes of Head-supported Mass Under Accelerative Forces.

(Choi H, Purushothaman Y, Gupta B, Banerjee A, Yoganandan N.) Mil Med. 2023 Nov 08;188(Suppl 6):458-465 PMID: 37948251 SCOPUS ID: 2-s2.0-85176426150 11/10/2023

Comparison of Axial Force Attenuation Characteristics in Two Different Lower Extremity Anthropomorphic Test Devices.

(Chirvi S, Pintar FA, Yoganandan N, Joseph McEntire B.) Mil Med. 2023 Nov 03;188(11-12):e3447-e3453 PMID: 37552649 SCOPUS ID: 2-s2.0-85176509355 08/08/2023

Ferroptosis in Neurological Disease.

(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022

The Role of Magnetic Resonance Imaging and Computed Tomography in Spinal Cord Injury.

(Hussain O, Kaushal M, Agarwal N, Kurpad S, Shabani S.) Life (Basel). 2023 Aug 03;13(8) PMID: 37629537 PMCID: PMC10455833 SCOPUS ID: 2-s2.0-85168918079 08/26/2023

Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.

(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023

Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats.

(Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM.) Behav Brain Res. 2023 Feb 13;438:114181 PMID: 36330906 PMCID: PMC9993345 SCOPUS ID: 2-s2.0-85140915448 11/05/2022

Determinants of spinal cord stress and strain in degenerative cervical myelopathy: a patient-specific finite element study

(Vedantam A, Harinathan B, Purushothaman Y, Scripp S, Banerjee A, Warraich A, Budde MD, Yoganandan N.) Biomechanics and Modeling in Mechanobiology. December 2023;22(6):1789-1799 SCOPUS ID: 2-s2.0-85161620932 12/01/2023

Network analysis and relationship of symptom factors to functional outcomes and quality of life following mild traumatic brain injury: a TRACK-TBI study.

(Eagle SR, Jain S, Sun X, Preszler J, McCrea MA, Giacino JT, Manley GT, Okonkwo DO, Nelson LD, TRACK-TBI Investigators.) Front Neurol. 2023;14:1308540 PMID: 38148980 PMCID: PMC10750770 SCOPUS ID: 2-s2.0-85180654624 12/27/2023

Development and Validation of Nonhuman Primate Head-Neck Computational Model for Frontal Impact Injury Analysis

(Gerringer JW, Somasundaram K, Pintar FA.) ASME J. of Medical Diagnostics. Gerringer, J. W., Somasundaram, K., and Pintar, F. A. (October 9, 2023). Development and Validation of Nonhuman Primate Head-Neck Computational Model for Frontal Impact Injury Analysis. ASME. ASME J of Medical Diagnostics. August 2024; 7(3): 031003. 10/09/2023

Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats

(Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM.) Behavioural Brain Research. 13 February 2023;438 SCOPUS ID: 2-s2.0-85140915448 02/13/2023

Regional brain strain dependance on direction of head rotation

(Rooks TF, Baisden JL, Yoganandan N.) Accident Analysis and Prevention. December 2023;193 SCOPUS ID: 2-s2.0-85171616884 12/01/2023

Regional brain strain dependance on direction of head rotation Accident Analysis and Prevention

(Rooks T., Baisden, J., Yoganandan, N..) Accident Analysis and Prevention. Volume 193December 2023 12/01/2023

IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.

(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022

Obese Occupant Response in Reclined and Upright Seated Postures in Frontal Impacts.

(Somasundaram K, Humm JR, Yoganandan N, Hauschild H, Driesslein K, Pintar FA.) Stapp Car Crash J. 2022 Nov;66:31-68 PMID: 37733821 SCOPUS ID: 2-s2.0-85150993131 09/21/2023

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders.

(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021

Viral tools for mapping and modulating neural networks after spinal cord injury.

(Schrank S, Satkunendrarajah K.) Exp Neurol. 2022 May;351:113995 PMID: 35123955 SCOPUS ID: 2-s2.0-85124103217 02/07/2022

Spinal cord injury and degenerative cervical myelopathy.

(Satkunendrarajah K, Karadimas SK, Fehlings MG.) Handb Clin Neurol. 2022;189:241-257 PMID: 36031307 SCOPUS ID: 2-s2.0-85136594983 08/29/2022

Correction to: CCL3 contributes to secondary damage after spinal cord injury.

(Pelisch N, Almanza JR, Stehlik KE, Aperi BV, Kroner A.) J Neuroinflammation. 2021 Apr 03;18(1):87 PMID: 33812368 PMCID: PMC8019158 04/05/2021

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.

(Zholudeva LV, Abraira VE, Satkunendrarajah K, McDevitt TC, Goulding MD, Magnuson DSK, Lane MA.) J Neurosci. 2021 Feb 03;41(5):845-854 PMID: 33472820 PMCID: PMC7880285 SCOPUS ID: 2-s2.0-85101994444 01/22/2021

Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models.

(Laliberte AM, Karadimas SK, Vidal PM, Satkunendrarajah K, Fehlings MG.) Brain Commun. 2021;3(1):fcaa234 PMID: 33604572 PMCID: PMC7878254 02/20/2021

Bilateral cervical contusion spinal cord injury: A mouse model to evaluate sensorimotor function.

(Reinhardt DR, Stehlik KE, Satkunendrarajah K, Kroner A.) Exp Neurol. 2020 Sep;331:113381 PMID: 32561411 SCOPUS ID: 2-s2.0-85086575731 06/21/2020

Sensory cortical control of movement.

(Karadimas SK, Satkunendrarajah K, Laliberte AM, Ringuette D, Weisspapir I, Li L, Gosgnach S, Fehlings MG.) Nat Neurosci. 2020 Jan;23(1):75-84 PMID: 31740813 SCOPUS ID: 2-s2.0-85075146992 11/20/2019

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2

(Williams JJ, Vazquez AL, Schwartz AB.) International IEEE/EMBS Conference on Neural Engineering, NER. 16 May 2019;2019-March:534-537 SCOPUS ID: 2-s2.0-85066753496 05/16/2019

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.

(Williams JJ, Watson AM, Vazquez AL, Schwartz AB.) Front Neurosci. 2019;13:759 PMID: 31417342 PMCID: PMC6684788 08/17/2019

Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface.

(Michelson NJ, Vazquez AL, Eles JR, Salatino JW, Purcell EK, Williams JJ, Cui XT, Kozai TDY.) J Neural Eng. 2018 Jun;15(3):033001 PMID: 29182149 PMCID: PMC5967409 SCOPUS ID: 2-s2.0-85047317370 11/29/2017

Spatial co-adaptation of cortical control columns in a micro-ECoG brain-computer interface.

(Rouse AG, Williams JJ, Wheeler JJ, Moran DW.) J Neural Eng. 2016 Oct;13(5):056018 PMID: 27651034 09/22/2016

Idle state classification using spiking activity and local field potentials in a brain computer interface.

(Williams JJ, Tien RN, Inoue Y, Schwartz AB.) Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:1572-1575 PMID: 28268628 SCOPUS ID: 2-s2.0-85009083903 03/09/2017

Differentiating closed-loop cortical intention from rest: building an asynchronous electrocorticographic BCI.

(Williams JJ, Rouse AG, Thongpang S, Williams JC, Moran DW.) J Neural Eng. 2013 Aug;10(4):046001 PMID: 23715295 SCOPUS ID: 2-s2.0-84883151862 05/30/2013