Recent Publications from the Zablocki VA Medical Center Research Laboratories

The Histological and Mechanical Behavior of Skin During Puncture for Different Impactor Sizes and Loading Rates.

(LeSueur J, Koser J, Dzwierzynski W, Stemper BD, Hampton CE, Kleinberger M, Pintar FA.) Ann Biomed Eng. 2025 May;53(5):1209-1225 PMID: 40053222 03/07/2025

In Reply: AO Spine & Praxis Spinal Cord Institute Clinical Practice Guidelines for the Management of Acute Spinal Cord Injury.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) Neurosurgery. 2025 Mar 01;96(3):e61-e63 PMID: 39853094 SCOPUS ID: 2-s2.0-85216566942 01/24/2025

Progesterone and Estradiol Levels Associated with Concussion and Clinical Outcomes and Recovery in Female Athletes and Cadets.

(Goeckner BD, Huber DL, VAN Bortel K, Gill JM, Mannix R, Master CL, Brett BL, Pasquina PF, Broglio SP, McAllister TW, Harezlak J, McCrea MA, Meier TB, CARE CONSORTIUM INVESTIGATORS.) Med Sci Sports Exerc. 2025 Mar 01;57(3):524-534 PMID: 39501473 PMCID: PMC11828682 SCOPUS ID: 2-s2.0-85209088291 11/06/2024

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

(Santini T, Shim A, Liou JJ, Rahman N, Varela-Mattatall G, Budde MD, Inoue W, Everling S, Baron CA.) Magn Reson Med. 2025 Feb;93(2):788-802 PMID: 39323069 PMCID: PMC11604852 SCOPUS ID: 2-s2.0-85205058687 09/26/2024

Editorial. The AO Spine/Praxis Spinal Cord Institute clinical practice guidelines for acute spinal cord injury: interpretation and implications for clinical practice.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) J Neurosurg Spine. 2025 Jan 24;42(4):526-529 PMID: 39854702 SCOPUS ID: 2-s2.0-105001864128 01/24/2025

Long-term neurobehavioral and neuroimaging outcomes in athletes with prior concussion(s) and head impact exposure.

(Brett BL, Sullivan ME, Asken BM, Terry DP, Meier TB, McCrea MA.) Clin Neuropsychol. 2025 Jan 11:1-29 PMID: 39797596 SCOPUS ID: 2-s2.0-85214670242 01/11/2025

Quantifying the Diagnostic Utility of Baseline Testing in Concussion Management: An Analysis of Collegiate Athletes From the NCAA-DoD CARE Consortium Dataset.

(Pandey HS, Lahijanian B, Schmidt JD, Lynall RC, Broglio SP, McAllister TW, McCrea MA, Pasquina PF, Garcia GP, CARE Consortium Investigators.) Am J Sports Med. 2025 Jan;53(1):181-191 PMID: 39741470 SCOPUS ID: 2-s2.0-85213986863 01/01/2025

Factors Associated With Return to Activity After Concussion Among Female Service Academy Members: Findings From the NCAA-DoD CARE Consortium.

(Jain D, Caccese JB, Boltz AJ, Buckley T, Cameron KL, Chrisman SPD, Clugston JR, Eckner JT, Ermer E, Scott FG, Harcum S, Hunt TN, Jannace KC, Kelly LA, Lempke LB, McDevitt J, Memmini A, Mozel A, Putukian M, Robb JB, Susmarski AJ, Syrydiuk RA, Broglio SP, McAllister TW, McCrea MA, Pasquina PF, Master CL, Esopenko C.) Mil Med. 2024 Dec 10 PMID: 39658275 12/11/2024

Mechanical Characterization of Non-degraded Porcine Annulus Fibrosus Material Properties.

(Seifert J, Maiman D, Frazer LL, Shah A, Yoganandan N, King K, Sheehy JB, Paskoff G, Bentley T, Nicolella DP, Stemper BD.) Ann Biomed Eng. 2024 Nov 05 PMID: 39499364 SCOPUS ID: 2-s2.0-85208479174 11/05/2024

Analysis of Injury Metrics From Experimental Cardiac Injuries From Behind Armor Blunt Trauma Using Live Swine Tests: A Pilot Study.

(Yoganandan N, Shah A, Koser J, Somberg L, Stemper BD, Chancey VC, McEntire JB.) Mil Med. 2024 Nov 05;189(11-12):e2462-e2467 PMID: 38877895 SCOPUS ID: 2-s2.0-85208601368 06/15/2024

Subclinical brain manifestations of repeated mild traumatic brain injury are changed by chronic exposure to sleep loss, caffeine, and sleep aids.

(Everson CA, Szabo A, Plyer C, Hammeke TA, Stemper BD, Budde MD.) Exp Neurol. 2024 Nov;381:114928 PMID: 39168169 SCOPUS ID: 2-s2.0-85201764724 08/22/2024

Clinical profile of patients with acute traumatic brain injury undergoing cranial surgery in the United States: report from the 18-centre TRACK-TBI cohort study.

(Yue JK, Kanter JH, Barber JK, Huang MC, van Essen TA, Elguindy MM, Foreman B, Korley FK, Belton PJ, Pisică D, Lee YM, Kitagawa RS, Vassar MJ, Sun X, Satris GG, Wong JC, Ferguson AR, Huie JR, Wang KKW, Deng H, Wang VY, Bodien YG, Taylor SR, Madhok DY, McCrea MA, Ngwenya LB, DiGiorgio AM, Tarapore PE, Stein MB, Puccio AM, Giacino JT, Diaz-Arrastia R, Lingsma HF, Mukherjee P, Yuh EL, Robertson CS, Menon DK, Maas AIR, Markowitz AJ, Jain S, Okonkwo DO, Temkin NR, Manley GT, TRACK-TBI Investigators.) Lancet Reg Health Am. 2024 Nov;39:100915 PMID: 39497836 PMCID: PMC11532273 11/05/2024

Expanded Combined Loading Injury Criterion for the Human Lumbar Spine Under Dynamic Compression.

(Ortiz-Paparoni M, Op 't Eynde J, Eckersley C, Morino C, Abrams M, Pang D, Kait J, Pintar F, Yoganandan N, Moore J, Barnes D, Loftis K, Bass CR.) Ann Biomed Eng. 2024 Nov;52(11):3067-3077 PMID: 39240473 SCOPUS ID: 2-s2.0-85203121909 09/06/2024

Evaluation of synthetic clear gelatin as an acceptable surrogate for low-velocity penetrating impacts using the depth of penetration calibration standard.

(LeSueur J, Koser J, Hargarten S, Pintar FA.) J Mech Behav Biomed Mater. 2024 Nov;159:106710 PMID: 39216336 SCOPUS ID: 2-s2.0-85202354471 09/01/2024

Lumbar Spine Orientation Affects Compressive Fracture Outcome.

(Cutlan R, Khokhar M, Shammout N, Shah AS, Frazer L, Yoganandan N, Shender BS, Sheehy J, Paskoff G, Nicolella D, Bentley T, Shabani S, Stemper BD.) Ann Biomed Eng. 2024 Oct 25 PMID: 39453511 10/25/2024

Effect of sagittal alignment on spinal cord biomechanics in the stenotic cervical spine during neck flexion and extension.

(Gundamraj S, Devaraj KB, Harinathan B, Banerjee A, Yoganandan N, Vedantam A.) Biomech Model Mechanobiol. 2024 Oct;23(5):1757-1764 PMID: 39003653 SCOPUS ID: 2-s2.0-85198355255 07/14/2024

Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization.

(Koch KM, Nencka AS, Kurpad S, Budde MD.) J Neurotrauma. 2024 Sep;41(17-18):2125-2132 PMID: 38251658 SCOPUS ID: 2-s2.0-85190264996 01/22/2024

Penetration Thresholds of Porcine Limbs for Low Sectional Density Projectiles in High-Rate Impact.

(LeSueur J, Koser J, Hampton C, Kleinberger M, Pintar FA.) Mil Med. 2024 Aug 19;189(Suppl 3):517-524 PMID: 39160835 SCOPUS ID: 2-s2.0-85201743644 08/20/2024

Behind Armor Blunt Trauma: Liver Injuries Using a Live Animal Model.

(Yoganandan N, Shah A, Koser J, Stemper BD, Somberg L, Chancey VC, McEntire J.) Mil Med. 2024 Aug 19;189(Suppl 3):659-664 PMID: 39160873 SCOPUS ID: 2-s2.0-85201736818 08/20/2024

Is Posterior Cervical Foraminotomy Better Than Fusion for Warfighters?: A Biomechanical Study.

(Choi H, Purushothaman Y, Ozobu I, Yoganandan N.) Mil Med. 2024 Aug 19;189(Suppl 3):710-718 PMID: 39160815 SCOPUS ID: 2-s2.0-85201744350 08/20/2024

Hybrid III Manikin Lumbar Spine Loading Under Vertical Impact.

(Yoganandan N, Moore J, Westerhof TA, Flierman NA.) Mil Med. 2024 Aug 19;189(Suppl 3):55-62 PMID: 39160828 SCOPUS ID: 2-s2.0-85201737711 08/20/2024

A minimum data set-Core outcome set, core data elements, and core measurement set-For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study.

(Davies BM, Yang X, Khan DZ, Mowforth OD, Touzet AY, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Blizzard T, Treanor C, Anderson D, Fallah N, Hazenbiller O, Salzman C, Zimmerman Z, Wandycz AM, Widdop S, Reeves M, Raine R, Ryan SK, Malone A, Gharooni A, Wilson JR, Martin AR, Fehlings MG, McNair AGK, Kotter MRN, AO SPINE RECODE-DCM Steering Committee and AO Spine RECODE DCM Community.) PLoS Med. 2024 Aug;21(8):e1004447 PMID: 39173109 PMCID: PMC11379399 SCOPUS ID: 2-s2.0-85201785269 08/22/2024

In vitro skin puncture methodology for material characterization.

(LeSueur J, Hampton C, Kleinberger M, Dzwierzynski W, Pintar FA.) Med Eng Phys. 2024 Aug;130:104199 PMID: 39160027 SCOPUS ID: 2-s2.0-85197026415 08/20/2024

Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury.

(Ryan F, Blex C, Ngo TD, Kopp MA, Michalke B, Venkataramani V, Curran L, Schwab JM, Ruprecht K, Otto C, Jhelum P, Kroner A, David S.) Acta Neuropathol. 2024 Jun 22;147(1):106 PMID: 38907771 PMCID: PMC11193702 06/22/2024

Cervical spinal cord angiography and vessel-selective perfusion imaging in the rat.

(Lee S, Schmit BD, Kurpad SN, Budde MD.) NMR Biomed. 2024 Jun;37(6):e5115 PMID: 38355219 PMCID: PMC11078600 SCOPUS ID: 2-s2.0-85185526294 02/15/2024

A guiding light for stimulating paralyzed muscles.

(Williams J.) Sci Robot. 2024 May 22;9(90):eado9987 PMID: 38776376 SCOPUS ID: 2-s2.0-85194016732 05/22/2024

Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

(Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak AV, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers JM, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Laganà MM, Laule C, Law CSW, Leutritz T, Liu Y, Llufriu S, Mackey S, Martin AR, Martinez-Heras E, Mattera L, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley GW, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J, Cohen-Adad J, Lenglet C, Nestrašil I.) bioRxiv. 2024 May 01 PMID: 38746371 PMCID: PMC11092490 05/15/2024

An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery.

(Fehlings MG, Tetreault LA, Hachem L, Evaniew N, Ganau M, McKenna SL, Neal CJ, Nagoshi N, Rahimi-Movaghar V, Aarabi B, Hofstetter CP, Wengel VT, Nakashima H, Martin AR, Kirshblum S, Rodrigues Pinto R, Marco RAW, Wilson JR, Kahn DE, Newcombe VFJ, Zipser CM, Douglas S, Kurpad SN, Lu Y, Saigal R, Samadani U, Arnold PM, Hawryluk GWJ, Skelly AC, Kwon BK.) Global Spine J. 2024 Mar;14(3_suppl):174S-186S PMID: 38526922 PMCID: PMC10964895 03/25/2024

Tensor-valued diffusion MRI of human acute stroke

(Zhou M, Stobbe R, Szczepankiewicz F, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Nilsson M, Westin CF, Beaulieu C.) Magnetic Resonance in Medicine. May 2024;91(5):2126-2141 SCOPUS ID: 2-s2.0-85181197209 05/01/2024

We Choose to Call it ‘Degenerative Cervical Myelopathy’: Findings of AO Spine RECODE-DCM, an International and Multi-Stakeholder Partnership to Agree a Standard Unifying Term and Definition for a Disease

(Davies BM, Khan DZ, Barzangi K, Ali A, Mowforth OD, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Widdop S, Fehlings MG, Kotter MRN.) Global Spine Journal. March 2024;14(2):503-512 SCOPUS ID: 2-s2.0-85133336136 03/01/2024

A Practical Classification System for Acute Cervical Spinal Cord Injury Based on a Three-Phased Modified Delphi Process From the AOSpine Spinal Cord Injury Knowledge Forum

(Hachem LD, Zhu M, Aarabi B, Davies B, DiGiorgio A, Evaniew N, Fehlings MG, Ganau M, Graves D, Guest J, Ha Y, Harrop J, Hofstetter C, Koljonen P, Kurpad S, Marco R, Martin AR, Nagoshi N, Nouri A, Rahimi-Movaghar V, Rodrigues-Pinto R, Wengel Vt, Tetreault L, Kwon B, Wilson JR.) Global Spine Journal. March 2024;14(2):535-545 SCOPUS ID: 2-s2.0-85138317004 03/01/2024

Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts

(Kals M, Wilson L, Levey DF, Parodi L, Steyerberg EW, Richardson S, He F, Sun X, Jain S, Palotie A, Ripatti S, Rosand J, Manley GT, Maas AIR, Stein MB, Menon DK, Ackerlund C, Adams H, Amrein K, Andelic N, Andreassen L, Anke A, Antoni A, Audibert G, Azouvi P, Azzolini ML, Bartels R, Barzó P, Beauvais R, Beer R, Bellander BM, Belli A, Benali H, Berardino M, Beretta L, Blaabjerg M, Bragge P, Brazinova A, Brinck V, Brooker J, Brorsson C, Buki A, Bullinger M, Cabeleira M, Caccioppola A, Calappi E, Calvi MR, Cameron P, Lozano GC, Carbonara M, Castaño-León AM, Cavallo S, Chevallard G, Chieregato A, Citerio G, Clusmann H, Coburn MS, Coles J, Cooper JD, Correia M, Čović A, Curry N, Czeiter E, Czosnyka M, Dahyot-Fizelier C, Dark P, Dawes H, De Keyser V, Degos V, Della Corte F, Boogert Hd, Depreitere B, Đilvesi Đ, Dixit A, Donoghue E, Dreier J, Dulière GL, Ercole A, Esser P, Ezer E, Fabricius M, Feigin VL, Foks K, Frisvold S, Furmanov A, Gagliardo P, Galanaud D, Gantner D, Gao G, George P, Ghuysen A, Giga L, Glocker B, Golubović J, Gomez PA, Gratz J, Gravesteijn B, Grossi F, Gruen RL, Gupta D.) eClinicalMedicine. December 2024;78 SCOPUS ID: 2-s2.0-85211046835 12/01/2024

Visualizing and quantifying the energy of bullets: Does it matter clinically?

(LeSueur J, Pintar FA, Hargarten S.) Visual Journal of Emergency Medicine. October 2024;37 SCOPUS ID: 2-s2.0-85203456150 10/01/2024

Subclinical respiratory dysfunction and impaired ventilatory adaptation in degenerative cervical myelopathy.

(Sweetman H, Rahman M, Vedantam A, Satkunendrarajah K.) Exp Neurol. 2024 Jan;371:114600 PMID: 37907124 SCOPUS ID: 2-s2.0-85175540178 11/01/2023

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation

(Moravec EM, Williams JJ.) Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2024 SCOPUS ID: 2-s2.0-85214968946 01/01/2024

Using Finite Element Models to Assess Spinal Cord Biomechanics after Cervical Laminoplasty for Degenerative Cervical Myelopathy

(Rahman M, Palmer P, Harinathan B, Banurekha Devaraj K, Yoganandan N, Vedantam A.) Diagnostics. July 2024;14(14) SCOPUS ID: 2-s2.0-85199590245 07/01/2024

Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice.

(St-Pierre MK, González Ibáñez F, Kroner A, Tremblay MÈ.) J Neuroinflammation. 2023 Nov 21;20(1):273 PMID: 37990235 PMCID: PMC10664529 11/22/2023

Ferroptosis in Neurological Disease.

(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022

Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.

(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023

IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.

(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders.

(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021

Viral tools for mapping and modulating neural networks after spinal cord injury.

(Schrank S, Satkunendrarajah K.) Exp Neurol. 2022 May;351:113995 PMID: 35123955 SCOPUS ID: 2-s2.0-85124103217 02/07/2022

Spinal cord injury and degenerative cervical myelopathy.

(Satkunendrarajah K, Karadimas SK, Fehlings MG.) Handb Clin Neurol. 2022;189:241-257 PMID: 36031307 SCOPUS ID: 2-s2.0-85136594983 08/29/2022

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.

(Zholudeva LV, Abraira VE, Satkunendrarajah K, McDevitt TC, Goulding MD, Magnuson DSK, Lane MA.) J Neurosci. 2021 Feb 03;41(5):845-854 PMID: 33472820 PMCID: PMC7880285 SCOPUS ID: 2-s2.0-85101994444 01/22/2021

Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models.

(Laliberte AM, Karadimas SK, Vidal PM, Satkunendrarajah K, Fehlings MG.) Brain Commun. 2021;3(1):fcaa234 PMID: 33604572 PMCID: PMC7878254 02/20/2021

Bilateral cervical contusion spinal cord injury: A mouse model to evaluate sensorimotor function.

(Reinhardt DR, Stehlik KE, Satkunendrarajah K, Kroner A.) Exp Neurol. 2020 Sep;331:113381 PMID: 32561411 SCOPUS ID: 2-s2.0-85086575731 06/21/2020

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2

(Williams JJ, Vazquez AL, Schwartz AB.) International IEEE/EMBS Conference on Neural Engineering, NER. 16 May 2019;2019-March:534-537 SCOPUS ID: 2-s2.0-85066753496 05/16/2019

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.

(Williams JJ, Watson AM, Vazquez AL, Schwartz AB.) Front Neurosci. 2019;13:759 PMID: 31417342 PMCID: PMC6684788 08/17/2019

Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface.

(Michelson NJ, Vazquez AL, Eles JR, Salatino JW, Purcell EK, Williams JJ, Cui XT, Kozai TDY.) J Neural Eng. 2018 Jun;15(3):033001 PMID: 29182149 PMCID: PMC5967409 SCOPUS ID: 2-s2.0-85047317370 11/29/2017

Idle state classification using spiking activity and local field potentials in a brain computer interface.

(Williams JJ, Tien RN, Inoue Y, Schwartz AB.) Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:1572-1575 PMID: 28268628 SCOPUS ID: 2-s2.0-85009083903 03/09/2017