Recent Publications from the Zablocki VA Medical Center Research Laboratories

Experimental wound ballistic study to understand biomechanical differences in gunshot wounds from various bullets and firearms: implications for clinical care and forensic analysis.

(LeSueur J, Koser J, Chadwick T, Milia DJ, Pintar FA, Hargarten S.) Forensic Sci Med Pathol. 2025 Nov 11 PMID: 41217633 11/11/2025

Prediction of Symptom Burden, Cognitive Status, and Risk of Psychological Distress in NCAA Athletes with Sport-Related Concussion(s): Findings from the NCAA-DoD CARE Consortium.

(Czerniak LL, Garcia GP, Genthe MW, Xia Y, Lavieri MS, McCrea MA, McAllister TW, Pasquina PF, Liebel SW, Broglio SP, CARE Consortium Investigators.) Ann Biomed Eng. 2025 Nov;53(11):3172-3189 PMID: 40813735 SCOPUS ID: 2-s2.0-105016653378 08/15/2025

Lap belt-induced Iliac Wing Fracture Risk Curve Development for Female PMHS in Frontal Sled Tests.

(Somasundaram K, Yoganandan N, Pintar F.) Ann Biomed Eng. 2025 Nov;53(11):3156-3171 PMID: 40846798 SCOPUS ID: 2-s2.0-105013821984 08/23/2025

One-Year Outcomes After Traumatic Brain Injury and Early Extracranial Surgery in the TRACK-TBI Study.

(Roberts CJ, Maiga AW, Barber J, Temkin NR, Vala R, Patel MB, Robertson CS, Valadka AB, Yue JK, Markowitz AJ, Manley GT, Nelson LD, Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) Investigators, Duhaime AC, Foreman B, Grandhi R, Keene CD, Krishnamoorthy V, Mac Donald C, McCrea M, Merchant R, Ngwenya LB, Puccio A, Rodgers RB, Schnyer D, Taylor SR, Zafonte R.) JAMA Netw Open. 2025 Oct 01;8(10):e2537271 PMID: 41071547 PMCID: PMC12514633 SCOPUS ID: 2-s2.0-105018397976 10/10/2025

Acute Surgery vs Conservative Treatment for Traumatic Acute Subdural Hematoma.

(Van Essen TA, Yue JK, Barber J, Lingsma HF, Pisica D, den Boogert HF, van Dijck JT, Moojen WA, Hutchinson P, Markowitz AJ, Steyerberg EW, Okonkwo DO, Bodien YG, Valadka AB, Diaz-Arrastia R, Robertson CS, Foreman B, Wang VY, McCrea MA, Giacino JT, Yuh EL, de Ruiter GCW, Temkin NR, Maas AIR, Peul WC, Manley GT, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study Investigators.) JAMA Netw Open. 2025 Oct 01;8(10):e2535200 PMID: 41042512 PMCID: PMC12495496 SCOPUS ID: 2-s2.0-105017606016 10/03/2025

Methods for assessing submarining occurrence in PMHS frontal sled tests: Exploring potential indicators.

(Somasundaram K, Driesslein K, Banerjee A, Pintar FA.) Traffic Inj Prev. 2025 Oct;26(sup1):S276-S286 PMID: 40929514 SCOPUS ID: 2-s2.0-105016168908 09/10/2025

Abnormal Pattern of Spondylosis and Postflight Neck Flexibility in Fifth-Generation Fighter Pilots.

(Stemper BD, Muftuler LT, Cutlan R, Strother C, Sherman KA, Meier TB, Raff H, Yoganandan N, Gerds B, Dooley C, Le P, Hainsworth KR, Vedantam A.) Aerosp Med Hum Perform. 2025 Oct;96(10):884-893 PMID: 41043817 SCOPUS ID: 2-s2.0-105017693987 10/04/2025

Mechanical and structural changes to the annulus fibrosus in response to Sub-failure cyclic loading.

(Seifert J, Frazer LL, Maiman D, Shah A, Shaffer SK, Yoganandan N, Sheehy JB, Bentley T, Nicolella DP, Stemper BD.) Acta Biomater. 2025 Oct 01;205:478-490 PMID: 40882904 SCOPUS ID: 2-s2.0-105015348955 08/30/2025

The cumulative effects of a collegiate athletic career on general health measures: findings from the CARE Consortium.

(Syrydiuk RA, Li C, Memmini AK, Boltz AJ, Lempke LB, Ren J, Perkins SM, Harezlak J, Mosesso KM, Pasquina PF, McAllister TW, McCrea MA, Broglio SP, CARE Consortium Investigators.) Brain Inj. 2025 Sep 17:1-10 PMID: 40963225 SCOPUS ID: 2-s2.0-105018457347 09/18/2025

Measuring Neck Morphologies Using Upright Magnetic Resonance Imaging.

(Yoganandan N, Rahman M, Warriach A, Devaraj KB, Stemper B, Vedantam A, Wolfla C, Le P.) Mil Med. 2025 Sep 01;190(Supplement_2):260-267 PMID: 40984125 SCOPUS ID: 2-s2.0-105016672377 09/23/2025

A Systematic Literature Review of Impact Systems for Developing Generalized Medical Injury Criteria for Behind Armor Blunt Trauma.

(Yoganandan N, Stemper B, Bass CR, Salzar R, Chancey VC, McEntire JB.) Mil Med. 2025 Sep 01;190(Supplement_2):632-639 PMID: 40984130 SCOPUS ID: 2-s2.0-105016552683 09/23/2025

Lung Injury Risk Curves From Behind Armor Blunt Trauma Using a Live Swine Model.

(Yoganandan N, Somberg L, Wilson D, Shah A, Koser J, Stemper B, Chancey VC, McEntire JB.) Mil Med. 2025 Sep 01;190(Supplement_2):755-760 PMID: 40984093 SCOPUS ID: 2-s2.0-105016689827 09/23/2025

Factors associated with concussion during combatives activities in a military training environment.

(Aderman MJ, Roach MH, Ward K, Malvasi SR, Ross JD, Svoboda SJ, Robb J, McGinty G, Jackson J, Brodeur RM, Susmarski A, Broglio SP, McCrea MA, McAllister T, Pasquina PF, Cameron KL.) J Sport Health Sci. 2025 Aug 14:101081 PMID: 40818615 08/17/2025

Change in Head Impact Exposure following Return-to-Sport in Concussed Football Athletes.

(Muench JR, Sinson GP, Glaeser B, Shah AS, Rowson S, Duma S, Mihalik J, Brooks A, Cameron K, Giza C, Goldman J, McGinty G, Riggen LD, Pasquina PF, Broglio SP, McAllister T, McCrea MA, Harezlak J, Stemper BD.) Med Sci Sports Exerc. 2025 Aug 08 PMID: 40778855 SCOPUS ID: 2-s2.0-105012983484 08/08/2025

The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique.

(Fehlings MG, Pedro KM, Alvi MA, Moghaddamjou A, Harrop JS, Stanford R, Ball J, Aarabi B, Arnold PM, Guest JD, Kurpad SN, Schuster JM, Nassr AN, Schmitt KM, Wilson JR, Brodke DS, Ahmad FU, Yee A, Ray WZ, Brooks NP, Wilson J, Chow DS, Toups EG, Thorpe KE, Huang J, Huang P.) EBioMedicine. 2025 Aug;118:105863 PMID: 40712181 PMCID: PMC12309938 SCOPUS ID: 2-s2.0-105011512607 07/25/2025

Validation and application of a finite element model simulating failure thresholds of skin during blunt puncture with varying impactor geometries.

(LeSueur J, Hampton CE, Pintar FA.) J Mech Behav Biomed Mater. 2025 Aug;168:107035 PMID: 40318470 SCOPUS ID: 2-s2.0-105003918220 05/04/2025

Impactor Displacement as a Predictor of Thoraco-Abdominal Organ Injury: Comparison of Isolated Organ to Whole Body Tests.

(Seifert J, Koser J, Shah A, Frazer L, Pintar FA, Yoganandan N, Nicolella D, Bentley TB, Stemper BD.) Ann Biomed Eng. 2025 Jul 14 PMID: 40658298 SCOPUS ID: 2-s2.0-105010678874 07/14/2025

Labeling phrenic afferents with intrapleural AAV-PHP.S.

(Morales AC, Holmes TC, Sanchez FT, Huang H, Williams JJ, Streeter KA.) J Neurosci Methods. 2025 Jul;419:110466 PMID: 40334752 PMCID: PMC12147650 SCOPUS ID: 2-s2.0-105004266981 05/08/2025

AO Spine Knowledge Forums Promote Collaboration and Elevate the Impact of Research: A Bibliometric Analysis.

(de Souza DN, Kurland DB, Vialle L, Schnake KJ, Kurpad SN, Lewis SJ, Schroeder GD, Yoon ST, Boriani S, Gokaslan Z, Rhines LD, Sahgal A, Fisher C, Laufer I.) Global Spine J. 2025 Jun 13:21925682251351012 PMID: 40513712 PMCID: PMC12165958 06/14/2025

AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy.

(Fehlings MG, Evaniew N, Ter Wengel PV, Vedantam A, Guha D, Margetis K, Nouri A, Ahmed AI, Neal CJ, Davies BM, Ganau M, Wilson JR, Martin AR, Grassner L, Tetreault L, Rahimi-Movaghar V, Marco R, Harrop J, Guest J, Alvi MA, Pedro KM, Kwon BK, Fisher CG, Kurpad SN, AO Spine Knowledge Forum Spinal Cord Injury.) Global Spine J. 2025 Jun;15(5):2585-2593 PMID: 40257837 PMCID: PMC12012498 SCOPUS ID: 2-s2.0-105004277039 04/21/2025

The Histological and Mechanical Behavior of Skin During Puncture for Different Impactor Sizes and Loading Rates.

(LeSueur J, Koser J, Dzwierzynski W, Stemper BD, Hampton CE, Kleinberger M, Pintar FA.) Ann Biomed Eng. 2025 May;53(5):1209-1225 PMID: 40053222 SCOPUS ID: 2-s2.0-86000310645 03/07/2025

In Reply: AO Spine & Praxis Spinal Cord Institute Clinical Practice Guidelines for the Management of Acute Spinal Cord Injury.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) Neurosurgery. 2025 Mar 01;96(3):e61-e63 PMID: 39853094 SCOPUS ID: 2-s2.0-85216566942 01/24/2025

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

(Santini T, Shim A, Liou JJ, Rahman N, Varela-Mattatall G, Budde MD, Inoue W, Everling S, Baron CA.) Magn Reson Med. 2025 Feb;93(2):788-802 PMID: 39323069 PMCID: PMC11604852 SCOPUS ID: 2-s2.0-85205058687 09/26/2024

Editorial. The AO Spine/Praxis Spinal Cord Institute clinical practice guidelines for acute spinal cord injury: interpretation and implications for clinical practice.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) J Neurosurg Spine. 2025 Jan 24;42(4):526-529 PMID: 39854702 SCOPUS ID: 2-s2.0-105001864128 01/24/2025

Novel Scoring Rules for Evaluation of Multiple Time-Like Scales with Interval Censored Data in Impact Crash Engineering Environments

(Banerjee A, Hu H, Yoganandan N.) Journal of the Indian Society for Probability and Statistics. December 2025;26(2):631-652 SCOPUS ID: 2-s2.0-105007001437 12/01/2025

Intramedullary Stress and Strain Correlate with Neurological Dysfunction in Degenerative Cervical Myelopathy

(Rahman M, Banurekha Devaraj K, Chauhan O, Harinathan B, Yoganandan N, Vedantam A.) Applied Sciences Switzerland. January 2025;15(2) SCOPUS ID: 2-s2.0-85215797547 01/01/2025

Mechanical Characterization of Non-degraded Porcine Annulus Fibrosus Material Properties.

(Seifert J, Maiman D, Frazer LL, Shah A, Yoganandan N, King K, Sheehy JB, Paskoff G, Bentley T, Nicolella DP, Stemper BD.) Ann Biomed Eng. 2024 Nov 05 PMID: 39499364 SCOPUS ID: 2-s2.0-85208479174 11/05/2024

Subclinical brain manifestations of repeated mild traumatic brain injury are changed by chronic exposure to sleep loss, caffeine, and sleep aids.

(Everson CA, Szabo A, Plyer C, Hammeke TA, Stemper BD, Budde MD.) Exp Neurol. 2024 Nov;381:114928 PMID: 39168169 SCOPUS ID: 2-s2.0-85201764724 08/22/2024

Expanded Combined Loading Injury Criterion for the Human Lumbar Spine Under Dynamic Compression.

(Ortiz-Paparoni M, Op 't Eynde J, Eckersley C, Morino C, Abrams M, Pang D, Kait J, Pintar F, Yoganandan N, Moore J, Barnes D, Loftis K, Bass CR.) Ann Biomed Eng. 2024 Nov;52(11):3067-3077 PMID: 39240473 SCOPUS ID: 2-s2.0-85203121909 09/06/2024

Comparative Biomechanical Analysis of Anterior Lumbar Interbody Fusion and Bilateral Expandable Transforaminal Lumbar Interbody Fusion Cages: A Finite Element Analysis Study.

(Bakhaidar M, Harinathan B, Devaraj KB, DeGroot A, Yoganandan N, Shabani S.) Int J Spine Surg. 2024 Sep 12;18(4):441-447 PMID: 39214603 PMCID: PMC11483624 08/31/2024

Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization.

(Koch KM, Nencka AS, Kurpad S, Budde MD.) J Neurotrauma. 2024 Sep;41(17-18):2125-2132 PMID: 38251658 PMCID: PMC12056579 SCOPUS ID: 2-s2.0-85190264996 01/22/2024

A minimum data set-Core outcome set, core data elements, and core measurement set-For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study.

(Davies BM, Yang X, Khan DZ, Mowforth OD, Touzet AY, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Blizzard T, Treanor C, Anderson D, Fallah N, Hazenbiller O, Salzman C, Zimmerman Z, Wandycz AM, Widdop S, Reeves M, Raine R, Ryan SK, Malone A, Gharooni A, Wilson JR, Martin AR, Fehlings MG, McNair AGK, Kotter MRN, AO SPINE RECODE-DCM Steering Committee and AO Spine RECODE DCM Community.) PLoS Med. 2024 Aug;21(8):e1004447 PMID: 39173109 PMCID: PMC11379399 SCOPUS ID: 2-s2.0-85201785269 08/22/2024

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation.

(Moravec EM, Williams JJ.) Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul;2024:1-5 PMID: 40039756 SCOPUS ID: 2-s2.0-85214968946 03/05/2025

Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury.

(Ryan F, Blex C, Ngo TD, Kopp MA, Michalke B, Venkataramani V, Curran L, Schwab JM, Ruprecht K, Otto C, Jhelum P, Kroner A, David S.) Acta Neuropathol. 2024 Jun 22;147(1):106 PMID: 38907771 PMCID: PMC11193702 06/22/2024

Cervical spinal cord angiography and vessel-selective perfusion imaging in the rat.

(Lee S, Schmit BD, Kurpad SN, Budde MD.) NMR Biomed. 2024 Jun;37(6):e5115 PMID: 38355219 PMCID: PMC11078600 SCOPUS ID: 2-s2.0-85185526294 02/15/2024

A guiding light for stimulating paralyzed muscles.

(Williams J.) Sci Robot. 2024 May 22;9(90):eado9987 PMID: 38776376 SCOPUS ID: 2-s2.0-85194016732 05/22/2024

Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

(Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak AV, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers JM, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Laganà MM, Laule C, Law CSW, Leutritz T, Liu Y, Llufriu S, Mackey S, Martin AR, Martinez-Heras E, Mattera L, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley GW, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J, Cohen-Adad J, Lenglet C, Nestrašil I.) bioRxiv. 2024 May 01 PMID: 38746371 PMCID: PMC11092490 05/15/2024

Tensor-valued diffusion MRI of human acute stroke

(Zhou M, Stobbe R, Szczepankiewicz F, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Nilsson M, Westin CF, Beaulieu C.) Magnetic Resonance in Medicine. May 2024;91(5):2126-2141 SCOPUS ID: 2-s2.0-85181197209 05/01/2024

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation

(Moravec EM, Williams JJ.) Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS. 2024 SCOPUS ID: 2-s2.0-85214968946 01/01/2024

Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice.

(St-Pierre MK, González Ibáñez F, Kroner A, Tremblay MÈ.) J Neuroinflammation. 2023 Nov 21;20(1):273 PMID: 37990235 PMCID: PMC10664529 11/22/2023

Ferroptosis in Neurological Disease.

(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022

Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.

(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023

IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.

(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders.

(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2

(Williams JJ, Vazquez AL, Schwartz AB.) International IEEE EMBS Conference on Neural Engineering Ner. 16 May 2019;2019-March:534-537 SCOPUS ID: 2-s2.0-85066753496 05/16/2019

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.

(Williams JJ, Watson AM, Vazquez AL, Schwartz AB.) Front Neurosci. 2019;13:759 PMID: 31417342 PMCID: PMC6684788 08/17/2019