Recent Publications from the Zablocki VA Medical Center Research Laboratories

Validation and application of a finite element model simulating failure thresholds of skin during blunt puncture with varying impactor geometries.

(LeSueur J, Hampton CE, Pintar FA.) J Mech Behav Biomed Mater. 2025 Aug;168:107035 PMID: 40318470 05/04/2025

Flight-associated cortisol dynamics and subjective assessments of pain and stress in fighter pilots: an exploratory study.

(Raff H, Hainsworth KR, Cutlan R, Sherman KA, Stemper BD.) Eur J Appl Physiol. 2025 Jun 13 PMID: 40512180 06/13/2025

AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy.

(Fehlings MG, Evaniew N, Ter Wengel PV, Vedantam A, Guha D, Margetis K, Nouri A, Ahmed AI, Neal CJ, Davies BM, Ganau M, Wilson JR, Martin AR, Grassner L, Tetreault L, Rahimi-Movaghar V, Marco R, Harrop J, Guest J, Alvi MA, Pedro KM, Kwon BK, Fisher CG, Kurpad SN, AO Spine Knowledge Forum Spinal Cord Injury.) Global Spine J. 2025 Jun;15(5):2585-2593 PMID: 40257837 PMCID: PMC12012498 SCOPUS ID: 2-s2.0-105004277039 04/21/2025

The Histological and Mechanical Behavior of Skin During Puncture for Different Impactor Sizes and Loading Rates.

(LeSueur J, Koser J, Dzwierzynski W, Stemper BD, Hampton CE, Kleinberger M, Pintar FA.) Ann Biomed Eng. 2025 May;53(5):1209-1225 PMID: 40053222 SCOPUS ID: 2-s2.0-86000310645 03/07/2025

Association of Subacute Mild Traumatic Brain Injury Symptoms With Long-Term Persistent Symptoms, Functional Limitations, and Quality of Life.

(Eagle SR, Temkin N, Barber JK, McCrea M, Giacino JT, Okonkwo D, Manley GT, Nelson L, TRACK-TBI Investigators.) Neurology. 2025 Apr 22;104(8):e213427 PMID: 40168631 PMCID: PMC11966525 SCOPUS ID: 2-s2.0-105002821584 04/01/2025

In Reply: AO Spine & Praxis Spinal Cord Institute Clinical Practice Guidelines for the Management of Acute Spinal Cord Injury.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) Neurosurgery. 2025 Mar 01;96(3):e61-e63 PMID: 39853094 SCOPUS ID: 2-s2.0-85216566942 01/24/2025

Effect of blood alcohol on the diagnostic accuracy of glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase L1 for traumatic intracranial hemorrhage: A TRACK-TBI study.

(Harris M, Yue JK, Jain S, Sun X, Puccio AM, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT, Korley FK, TRACK‐TBI Investigators.) Acad Emerg Med. 2025 Feb 18 PMID: 39967286 SCOPUS ID: 2-s2.0-85219212820 02/19/2025

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

(Santini T, Shim A, Liou JJ, Rahman N, Varela-Mattatall G, Budde MD, Inoue W, Everling S, Baron CA.) Magn Reson Med. 2025 Feb;93(2):788-802 PMID: 39323069 PMCID: PMC11604852 SCOPUS ID: 2-s2.0-85205058687 09/26/2024

Editorial. The AO Spine/Praxis Spinal Cord Institute clinical practice guidelines for acute spinal cord injury: interpretation and implications for clinical practice.

(Fehlings MG, Evaniew N, Kurpad SN, Skelly AC, Tetreault LA, Kwon BK.) J Neurosurg Spine. 2025 Jan 24;42(4):526-529 PMID: 39854702 SCOPUS ID: 2-s2.0-105001864128 01/24/2025

Factors Associated with Persisting Post-Concussion Symptoms Among Collegiate Athletes and Military Cadets: Findings from the NCAA-DoD CARE Consortium.

(Rooks LT, Bertò G, Pasquina PF, Broglio SP, McAllister TW, McCrea MA, Pestilli F, Port NL, CARE Consortium Investigators.) Sports Med. 2025 Jan 19 PMID: 39828869 01/20/2025

Association of blood-based glial fibrillary acidic protein level with depression and suicidal ideation following traumatic brain injury with Glasgow Coma Scale score 13 to 15: a TRACK-TBI study.

(Eagle SR, Gardner RC, Jain S, Sun X, Puccio A, Brent D, Nelson LD, McCrea MA, Giacino JT, Okonkwo DO, Yue JK, Manley GT, Stein MB, TRACK-TBI Investigators .) Brain Commun. 2025;7(2):fcaf123 PMID: 40190352 PMCID: PMC11968334 SCOPUS ID: 2-s2.0-105002234323 04/07/2025

Transition (From Sport) Experiences of Former National Football League Players: An NFL-LONG Study

(Defreese JD, Weight EA, Lempke LB, Walton SR, Kerr ZY, Brett BL, Chandran A, Mannix R, Echemendia RJ, McCrea MA, Meehan WP, Guskiewicz KM.) Journal of Clinical Sport Psychology. Mar 2025;19(1):78-96 SCOPUS ID: 2-s2.0-86000285903 03/01/2025

Association between magnetic resonance imaging use and recovery time following concussion: a CARE consortium study.

(Syrydiuk RA, Boltz AJ, Lempke LB, van Pelt K, Balendran V, Scott K, Vesia M, Giordani B, McCrea MA, McAllister TW, Broglio SP, CARE Consortium Investigators.) Res Sports Med. 2025;33(3):254-265 PMID: 39841534 SCOPUS ID: 2-s2.0-105002492119 01/22/2025

Mechanical Characterization of Non-degraded Porcine Annulus Fibrosus Material Properties.

(Seifert J, Maiman D, Frazer LL, Shah A, Yoganandan N, King K, Sheehy JB, Paskoff G, Bentley T, Nicolella DP, Stemper BD.) Ann Biomed Eng. 2024 Nov 05 PMID: 39499364 SCOPUS ID: 2-s2.0-85208479174 11/05/2024

Subclinical brain manifestations of repeated mild traumatic brain injury are changed by chronic exposure to sleep loss, caffeine, and sleep aids.

(Everson CA, Szabo A, Plyer C, Hammeke TA, Stemper BD, Budde MD.) Exp Neurol. 2024 Nov;381:114928 PMID: 39168169 SCOPUS ID: 2-s2.0-85201764724 08/22/2024

Expanded Combined Loading Injury Criterion for the Human Lumbar Spine Under Dynamic Compression.

(Ortiz-Paparoni M, Op 't Eynde J, Eckersley C, Morino C, Abrams M, Pang D, Kait J, Pintar F, Yoganandan N, Moore J, Barnes D, Loftis K, Bass CR.) Ann Biomed Eng. 2024 Nov;52(11):3067-3077 PMID: 39240473 SCOPUS ID: 2-s2.0-85203121909 09/06/2024

Evaluation of synthetic clear gelatin as an acceptable surrogate for low-velocity penetrating impacts using the depth of penetration calibration standard.

(LeSueur J, Koser J, Hargarten S, Pintar FA.) J Mech Behav Biomed Mater. 2024 Nov;159:106710 PMID: 39216336 SCOPUS ID: 2-s2.0-85202354471 09/01/2024

Lumbar Spine Orientation Affects Compressive Fracture Outcome.

(Cutlan R, Khokhar M, Shammout N, Shah AS, Frazer L, Yoganandan N, Shender BS, Sheehy J, Paskoff G, Nicolella D, Bentley T, Shabani S, Stemper BD.) Ann Biomed Eng. 2024 Oct 25 PMID: 39453511 10/25/2024

Effect of sagittal alignment on spinal cord biomechanics in the stenotic cervical spine during neck flexion and extension.

(Gundamraj S, Devaraj KB, Harinathan B, Banerjee A, Yoganandan N, Vedantam A.) Biomech Model Mechanobiol. 2024 Oct;23(5):1757-1764 PMID: 39003653 SCOPUS ID: 2-s2.0-85198355255 07/14/2024

Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization.

(Koch KM, Nencka AS, Kurpad S, Budde MD.) J Neurotrauma. 2024 Sep;41(17-18):2125-2132 PMID: 38251658 PMCID: PMC12056579 SCOPUS ID: 2-s2.0-85190264996 01/22/2024

Behind Armor Blunt Trauma: Liver Injuries Using a Live Animal Model.

(Yoganandan N, Shah A, Koser J, Stemper BD, Somberg L, Chancey VC, McEntire J.) Mil Med. 2024 Aug 19;189(Suppl 3):659-664 PMID: 39160873 SCOPUS ID: 2-s2.0-85201736818 08/20/2024

Is Posterior Cervical Foraminotomy Better Than Fusion for Warfighters?: A Biomechanical Study.

(Choi H, Purushothaman Y, Ozobu I, Yoganandan N.) Mil Med. 2024 Aug 19;189(Suppl 3):710-718 PMID: 39160815 SCOPUS ID: 2-s2.0-85201744350 08/20/2024

Hybrid III Manikin Lumbar Spine Loading Under Vertical Impact.

(Yoganandan N, Moore J, Westerhof TA, Flierman NA.) Mil Med. 2024 Aug 19;189(Suppl 3):55-62 PMID: 39160828 SCOPUS ID: 2-s2.0-85201737711 08/20/2024

A minimum data set-Core outcome set, core data elements, and core measurement set-For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study.

(Davies BM, Yang X, Khan DZ, Mowforth OD, Touzet AY, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Blizzard T, Treanor C, Anderson D, Fallah N, Hazenbiller O, Salzman C, Zimmerman Z, Wandycz AM, Widdop S, Reeves M, Raine R, Ryan SK, Malone A, Gharooni A, Wilson JR, Martin AR, Fehlings MG, McNair AGK, Kotter MRN, AO SPINE RECODE-DCM Steering Committee and AO Spine RECODE DCM Community.) PLoS Med. 2024 Aug;21(8):e1004447 PMID: 39173109 PMCID: PMC11379399 SCOPUS ID: 2-s2.0-85201785269 08/22/2024

In vitro skin puncture methodology for material characterization.

(LeSueur J, Hampton C, Kleinberger M, Dzwierzynski W, Pintar FA.) Med Eng Phys. 2024 Aug;130:104199 PMID: 39160027 SCOPUS ID: 2-s2.0-85197026415 08/20/2024

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation.

(Moravec EM, Williams JJ.) Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul;2024:1-5 PMID: 40039756 SCOPUS ID: 2-s2.0-85214968946 03/05/2025

Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury.

(Ryan F, Blex C, Ngo TD, Kopp MA, Michalke B, Venkataramani V, Curran L, Schwab JM, Ruprecht K, Otto C, Jhelum P, Kroner A, David S.) Acta Neuropathol. 2024 Jun 22;147(1):106 PMID: 38907771 PMCID: PMC11193702 06/22/2024

Cervical spinal cord angiography and vessel-selective perfusion imaging in the rat.

(Lee S, Schmit BD, Kurpad SN, Budde MD.) NMR Biomed. 2024 Jun;37(6):e5115 PMID: 38355219 PMCID: PMC11078600 SCOPUS ID: 2-s2.0-85185526294 02/15/2024

A guiding light for stimulating paralyzed muscles.

(Williams J.) Sci Robot. 2024 May 22;9(90):eado9987 PMID: 38776376 SCOPUS ID: 2-s2.0-85194016732 05/22/2024

Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

(Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak AV, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers JM, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Laganà MM, Laule C, Law CSW, Leutritz T, Liu Y, Llufriu S, Mackey S, Martin AR, Martinez-Heras E, Mattera L, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley GW, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J, Cohen-Adad J, Lenglet C, Nestrašil I.) bioRxiv. 2024 May 01 PMID: 38746371 PMCID: PMC11092490 05/15/2024

An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery.

(Fehlings MG, Tetreault LA, Hachem L, Evaniew N, Ganau M, McKenna SL, Neal CJ, Nagoshi N, Rahimi-Movaghar V, Aarabi B, Hofstetter CP, Wengel VT, Nakashima H, Martin AR, Kirshblum S, Rodrigues Pinto R, Marco RAW, Wilson JR, Kahn DE, Newcombe VFJ, Zipser CM, Douglas S, Kurpad SN, Lu Y, Saigal R, Samadani U, Arnold PM, Hawryluk GWJ, Skelly AC, Kwon BK.) Global Spine J. 2024 Mar;14(3_suppl):174S-186S PMID: 38526922 PMCID: PMC10964895 03/25/2024

Tensor-valued diffusion MRI of human acute stroke

(Zhou M, Stobbe R, Szczepankiewicz F, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Nilsson M, Westin CF, Beaulieu C.) Magnetic Resonance in Medicine. May 2024;91(5):2126-2141 SCOPUS ID: 2-s2.0-85181197209 05/01/2024

We Choose to Call it ‘Degenerative Cervical Myelopathy’: Findings of AO Spine RECODE-DCM, an International and Multi-Stakeholder Partnership to Agree a Standard Unifying Term and Definition for a Disease

(Davies BM, Khan DZ, Barzangi K, Ali A, Mowforth OD, Nouri A, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Tetreault L, Kwon BK, Boerger TF, Rodrigues-Pinto R, Furlan JC, Chen R, Zipser CM, Curt A, Milligan J, Kalsi-Rayn S, Sarewitz E, Sadler I, Widdop S, Fehlings MG, Kotter MRN.) Global Spine Journal. March 2024;14(2):503-512 SCOPUS ID: 2-s2.0-85133336136 03/01/2024

Visualizing and quantifying the energy of bullets: Does it matter clinically?

(LeSueur J, Pintar FA, Hargarten S.) Visual Journal of Emergency Medicine. October 2024;37 SCOPUS ID: 2-s2.0-85203456150 10/01/2024

Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation

(Moravec EM, Williams JJ.) Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS. 2024 SCOPUS ID: 2-s2.0-85214968946 01/01/2024

Using Finite Element Models to Assess Spinal Cord Biomechanics after Cervical Laminoplasty for Degenerative Cervical Myelopathy

(Rahman M, Palmer P, Harinathan B, Banurekha Devaraj K, Yoganandan N, Vedantam A.) Diagnostics. July 2024;14(14) SCOPUS ID: 2-s2.0-85199590245 07/01/2024

Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice.

(St-Pierre MK, González Ibáñez F, Kroner A, Tremblay MÈ.) J Neuroinflammation. 2023 Nov 21;20(1):273 PMID: 37990235 PMCID: PMC10664529 11/22/2023

Ferroptosis in Neurological Disease.

(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022

Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.

(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023

IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.

(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders.

(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2

(Williams JJ, Vazquez AL, Schwartz AB.) International IEEE EMBS Conference on Neural Engineering Ner. 16 May 2019;2019-March:534-537 SCOPUS ID: 2-s2.0-85066753496 05/16/2019

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.

(Williams JJ, Watson AM, Vazquez AL, Schwartz AB.) Front Neurosci. 2019;13:759 PMID: 31417342 PMCID: PMC6684788 08/17/2019

Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface.

(Michelson NJ, Vazquez AL, Eles JR, Salatino JW, Purcell EK, Williams JJ, Cui XT, Kozai TDY.) J Neural Eng. 2018 Jun;15(3):033001 PMID: 29182149 PMCID: PMC5967409 SCOPUS ID: 2-s2.0-85047317370 11/29/2017