Recent Publications from the Zablocki VA Medical Center Research Laboratories

Ferroptosis in Neurological Disease.

(David S, Ryan F, Jhelum P, Kroner A.) Neuroscientist. 2023 Oct;29(5):591-615 PMID: 35678019 06/10/2022

THOR-05F biofidelity evaluation in reclined and upright seated postures subjected to frontal crash pulses.

(Somasundaram K, Hauschild H, Driesslein K, Pintar F, Richardson R, Parent D.) Accid Anal Prev. 2023 Oct;191:107185 PMID: 37429156 SCOPUS ID: 2-s2.0-85164213472 07/11/2023

Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial.

(Fehlings MG, Moghaddamjou A, Harrop JS, Stanford R, Ball J, Aarabi B, Freeman BJC, Arnold PM, Guest JD, Kurpad SN, Schuster JM, Nassr A, Schmitt KM, Wilson JR, Brodke DS, Ahmad FU, Yee A, Ray WZ, Brooks NP, Wilson J, Chow DS, Toups EG, Kopjar B.) J Neurotrauma. 2023 Sep;40(17-18):1878-1888 PMID: 37279301 PMCID: PMC10460693 SCOPUS ID: 2-s2.0-85166327228 06/06/2023

Variability in Early Surgery for Acute Cervical Spinal Cord Injury Patients: An Opportunity for Enhanced Care Delivery.

(Neal CJ, Ugiliweneza B, Toups EG, Abd-El-Barr M, Jimsheleishvili G, Kurpad SN, Aarabi B, Harrop JS, Shaffrey CI, Fehlings MG, Tator CH, Grossman RG, Guest JD.) J Neurotrauma. 2023 Sep;40(17-18):1907-1917 PMID: 37125447 SCOPUS ID: 2-s2.0-85169848329 05/01/2023

Interhospital Transfer Delays Care for Spinal Cord Injury Patients: A Report from the North American Clinical Trials Network for Spinal Cord Injury.

(Kelly-Hedrick M, Ugiliweneza B, Toups EG, Jimsheleishvili G, Kurpad SN, Aarabi B, Harrop JS, Foster N, Goodwin RC, Shaffrey CI, Fehlings MG, Tator CH, Guest JD, Neal CJ, Abd-El-Barr MM, Williamson T.) J Neurotrauma. 2023 Sep;40(17-18):1928-1937 PMID: 37014079 SCOPUS ID: 2-s2.0-85169847022 04/05/2023

Preinjury Measures Do Not Predict Future Concussion Among Collegiate Student-Athletes: Findings From the CARE Consortium.

(Lempke LB, Breedlove KM, Caccese JB, McCrea MA, McAllister TW, Broglio SP, Schmidt JD, Lynall RC, Buckley TA, CARE Consortium Investigators.) Am J Phys Med Rehabil. 2023 Sep 01;102(9):823-828 PMID: 37339057 SCOPUS ID: 2-s2.0-85168247013 06/20/2023

Effect of muscle activation scheme in human head-neck model on estimating cervical spine ligament strain from military volunteer frontal impact data.

(Gerringer JW, Somasundaram K, Pintar FA.) Accid Anal Prev. 2023 Sep;190:107157 PMID: 37336050 SCOPUS ID: 2-s2.0-85162174423 06/20/2023

Increased brain age and relationships with blood-based biomarkers following concussion in younger populations.

(Mayer AR, Meier TB, Ling JM, Dodd AB, Brett BL, Robertson-Benta CR, Huber DL, Van der Horn HJ, Broglio SP, McCrea MA, McAllister T.) J Neurol. 2023 Aug 18 PMID: 37594499 SCOPUS ID: 2-s2.0-85168381808 08/18/2023

Long-term Multidomain Patterns of Change After Traumatic Brain Injury: A TRACK-TBI LONG Study.

(Brett BL, Temkin N, Barber JK, Okonkwo DO, Stein M, Bodien YG, Corrigan J, Diaz-Arrastia R, Giacino JT, McCrea MA, Manley GT, Nelson LD, for TRACK-TBI Investigators.) Neurology. 2023 Aug 15;101(7):e740-e753 PMID: 37344231 PMCID: PMC10437015 SCOPUS ID: 2-s2.0-85168222838 06/22/2023

Comparison of Axial Force Attenuation Characteristics in Two Different Lower Extremity Anthropomorphic Test Devices.

(Chirvi S, Pintar FA, Yoganandan N, Joseph McEntire B.) Mil Med. 2023 Aug 08 PMID: 37552649 08/08/2023

Secondary analysis of a James Lind Alliance priority setting partnership to facilitate knowledge translation in degenerative cervical myelopathy (DCM): insights from AO Spine RECODE-DCM.

(Davies B, Brannigan J, Mowforth OD, Khan D, McNair AGK, Tetreault L, Sadler I, Sarewitz E, Aarabi B, Kwon B, Gronlund T, Rahimi-Movaghar V, Zipser CM, Hutchinson PJ, Kurpad S, Harrop JS, Wilson JR, Guest JD, Fehlings MG, Kotter MRN.) BMJ Open. 2023 Jul 18;13(7):e064296 PMID: 37463815 PMCID: PMC10357680 SCOPUS ID: 2-s2.0-85165517288 07/19/2023

Differences in spinal cord biomechanics after laminectomy, laminoplasty, and laminectomy with fusion for degenerative cervical myelopathy.

(Vedantam A, Harinathan B, Warraich A, Budde MD, Yoganandan N.) J Neurosurg Spine. 2023 Jul 01;39(1):28-39 PMID: 37029671 SCOPUS ID: 2-s2.0-85164233516 04/09/2023

Association of obesity with mild traumatic brain injury symptoms, inflammatory profile, quality of life and functional outcomes: a TRACK-TBI Study.

(Eagle SR, Puccio AM, Nelson LD, McCrea M, Giacino J, Diaz-Arrastia R, Conkright W, Jain S, Sun X, Manley G, Okonkwo DO, TRACK-TBI Investigators.) J Neurol Neurosurg Psychiatry. 2023 Jun 27 PMID: 37369556 SCOPUS ID: 2-s2.0-85164412798 06/28/2023

Incidence of concussion and associated risk factors in collegiate soccer: findings from the NCAA-DoD CARE consortium.

(Kontos AP, Eagle SR, Chrisman SPD, Putukian M, Manderino L, Holland C, Collins MW, Broglio SP, McAllister TW, McCrea MA, Pasquina P, Kaminski TW, CARE Consortium Investigators.) Sci Med Footb. 2023 Jun 23:1-7 PMID: 37338928 06/20/2023

Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury.

(Page JJ, Almanza JR, Xiong S, Aishwarya V, Kroner A.) J Neuroimmunol. 2023 Jun 15;379:578103 PMID: 37172370 05/12/2023

Small Female Occupant Response in Reclined and Upright Seated Postures in Frontal Impacts.

(Somasundaram K, Hauschild H, Driesslein K, Pintar FA.) J Biomech Eng. 2023 Jun 09:1-35 PMID: 37295932 06/10/2023

Comparison and optimization of pCASL and VSASL for rat thoracolumbar spinal cord MRI at 9.4 T.

(Lee S, Meyer BP, Hernandez-Garcia L, Kurpad SN, Schmit BD, Budde MD.) Magn Reson Med. 2023 Jun;89(6):2305-2317 PMID: 36744728 PMCID: PMC10050093 SCOPUS ID: 2-s2.0-85147533572 02/07/2023

Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency.

(Nagree MS, Rybova J, Kleynerman A, Ahrenhoerster CJ, Saville JT, Xu T, Bachochin M, McKillop WM, Lawlor MW, Pshezhetsky AV, Isaeva O, Budde MD, Fuller M, Medin JA.) Commun Biol. 2023 May 25;6(1):560 PMID: 37231125 PMCID: PMC10212955 SCOPUS ID: 2-s2.0-85160222255 05/26/2023

Spinal Cord Stress After Anterior Cervical Diskectomy and Fusion: Results from a Patient-Specific Finite Element Model.

(Vedantam A, Purushothaman Y, Harinathan B, Scripp S, Budde MD, Yoganandan N.) Ann Biomed Eng. 2023 May;51(5):1040-1051 PMID: 36538274 SCOPUS ID: 2-s2.0-85144374871 12/21/2022

Lived experience-centred word clouds may improve research uncertainty gathering in priority setting partnerships.

(Mowforth OD, Burn L, Khan DZ, Yang X, Stacpoole SRL, Gronlund T, Tetreault L, Kalsi-Ryan S, Starkey ML, Sadler I, Sarewitz E, Houlton D, Carter J, Howard P, Rahimi-Movaghar V, Guest JD, Aarabi B, Kwon BK, Kurpad SN, Harrop J, Wilson JR, Grossman R, Smith EK, McNair A, Fehlings MG, Kotter MRN, Davies BM.) BMC Med Res Methodol. 2023 Apr 22;23(1):100 PMID: 37087419 PMCID: PMC10122197 SCOPUS ID: 2-s2.0-85153553685 04/23/2023

Temporal corridors of forces and moments, and injuries to pelvis-lumbar spine in vertical impact simulating underbody blast.

(Yoganandan N, Humm J, Baisden J, Moore J, Pintar F, Wassick M, Barnes D, Loftis K.) J Biomech. 2023 Mar;150:111490 PMID: 36878113 SCOPUS ID: 2-s2.0-85149387118 03/07/2023

Response of Thoraco-Abdominal Tissue in High-Rate Compression.

(Seifert J, Koser J, Shah AS, Frazer LL, Yoganandan N, Shender BS, Sheehy JB, Paskoff G, Bentley T, Nicolella DP, Stemper BD.) J Biomech Eng. 2023 Mar 01;145(3) PMID: 36301262 SCOPUS ID: 2-s2.0-85143552239 10/28/2022

A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla.

(Rahman N, Xu K, Budde MD, Brown A, Baron CA.) Sci Data. 2023 Feb 14;10(1):94 PMID: 36788251 PMCID: PMC9929084 SCOPUS ID: 2-s2.0-85148086939 02/15/2023

Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats.

(Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM.) Behav Brain Res. 2023 Feb 13;438:114181 PMID: 36330906 PMCID: PMC9993345 SCOPUS ID: 2-s2.0-85140915448 11/05/2022

Correction: The Human Lumbar Spine During High-Rate Under Seat Loading: A Combined Metric Injury Criterion.

(Ortiz-Paparoni M, Op't Eynde J, Kait J, Bigler B, Shridharani J, Schmidt A, Cox C, Morino C, Pintar F, Yoganandan N, Moore J, Zhang J, Bass CR.) Ann Biomed Eng. 2023 Feb;51(2):458 PMID: 36562848 SCOPUS ID: 2-s2.0-85144642125 12/24/2022

Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury

(Ahmed RU, Medina-Aguinaga D, Adams S, Knibbe CA, Morgan M, Gibson D, Kim Jw, Sharma M, Chopra M, Davison S, Sherwood LC, Negahdar MJ, Bert R, Ugiliweneza B, Hubscher C, Budde MD, Xu J, Boakye M.) Annals of Clinical and Translational Neurology. September 2023;10(9):1647-1661 SCOPUS ID: 2-s2.0-85165898607 09/01/2023

Diffusion-weighted MRI of the spinal cord in cervical spondylotic myelopathy after instrumented fusion.

(Koch KM, Nencka AS, Klein A, Wang M, Kurpad S, Vedantam A, Budde M.) Front Neurol. 2023;14:1172833 PMID: 37273696 PMCID: PMC10236479 SCOPUS ID: 2-s2.0-85161052826 06/05/2023

Early Exercise is Associated with Faster Concussion Recovery Among Collegiate Athletes: Findings from the NCAA-DoD CARE Consortium

(Lempke LB, Teel EF, Lynall RC, Hoffman NL, Buckley TA, Eckner JT, McCrea MA, McAllister TW, Broglio SP, Schmidt JD, Kelly LA, Ortega JD, Master CL, Port N, Giza CC, Kaminski TW, Feigenbaum LA, Collins M, Chrisman SPO, Brooks A, Susmarski A, Duma S, Clugston JR.) Sports Medicine. October 2023;53(10):1987-1999 SCOPUS ID: 2-s2.0-85159825382 10/01/2023

Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats

(Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM.) Behavioural Brain Research. 13 February 2023;438 SCOPUS ID: 2-s2.0-85140915448 02/13/2023

Regional variations in C1–C2 bone density on quantitated computed tomography and clinical implications

(Baisden JL, Varghese V, Banerjee A, Yoganandan N.) North American Spine Society Journal. June 2023;14 SCOPUS ID: 2-s2.0-85161288528 06/01/2023

Determinants of spinal cord stress and strain in degenerative cervical myelopathy: a patient-specific finite element study

(Vedantam A, Harinathan B, Purushothaman Y, Scripp S, Banerjee A, Warraich A, Budde MD, Yoganandan N.) Biomechanics and Modeling in Mechanobiology. 2023 SCOPUS ID: 2-s2.0-85161620932 01/01/2023

IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.

(Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A.) J Neurosci Res. 2022 Dec;100(12):2213-2231 PMID: 36089917 SCOPUS ID: 2-s2.0-85137752150 09/13/2022

Consensus Head Acceleration Measurement Practices (CHAMP): Study Design and Statistical Analysis.

(Rowson S, Mihalik J, Urban J, Schmidt J, Marshall S, Harezlak J, Stemper BD, McCrea M, Funk J.) Ann Biomed Eng. 2022 Nov;50(11):1346-1355 PMID: 36253602 PMCID: PMC9652215 SCOPUS ID: 2-s2.0-85140002883 10/18/2022

Time Delta Head Impact Frequency: An Analysis on Head Impact Exposure in the Lead Up to a Concussion: Findings from the NCAA-DOD Care Consortium.

(Seifert J, Shah AS, Harezlak J, Rowson S, Mihalik JP, Riggen L, Duma S, Brooks A, Cameron KL, Giza CC, Goldman J, Guskiewicz KM, Houston MN, Jackson JC, McGinty G, Pasquina P, Broglio SP, McAllister TW, McCrea MA, Stemper BD.) Ann Biomed Eng. 2022 Nov;50(11):1473-1487 PMID: 35933459 PMCID: PMC9652163 SCOPUS ID: 2-s2.0-85135698130 08/07/2022

Calcaneus fracture pattern and severity: Role of local trabecular bone density.

(Chirvi S, Pahapill N, Yoganandan N, Curry W, Stemper B, Kleinberger M, Pintar FA.) J Mech Behav Biomed Mater. 2022 Oct;134:105332 PMID: 35987107 SCOPUS ID: 2-s2.0-85136013753 08/21/2022

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders.

(David S, Jhelum P, Ryan F, Jeong SY, Kroner A.) Antioxid Redox Signal. 2022 Jul;37(1-3):150-170 PMID: 34569265 09/28/2021

Viral tools for mapping and modulating neural networks after spinal cord injury.

(Schrank S, Satkunendrarajah K.) Exp Neurol. 2022 May;351:113995 PMID: 35123955 SCOPUS ID: 2-s2.0-85124103217 02/07/2022

Spinal cord injury and degenerative cervical myelopathy.

(Satkunendrarajah K, Karadimas SK, Fehlings MG.) Handb Clin Neurol. 2022;189:241-257 PMID: 36031307 SCOPUS ID: 2-s2.0-85136594983 08/29/2022

Correction to: CCL3 contributes to secondary damage after spinal cord injury.

(Pelisch N, Almanza JR, Stehlik KE, Aperi BV, Kroner A.) J Neuroinflammation. 2021 Apr 03;18(1):87 PMID: 33812368 PMCID: PMC8019158 04/05/2021

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.

(Zholudeva LV, Abraira VE, Satkunendrarajah K, McDevitt TC, Goulding MD, Magnuson DSK, Lane MA.) J Neurosci. 2021 Feb 03;41(5):845-854 PMID: 33472820 PMCID: PMC7880285 SCOPUS ID: 2-s2.0-85101994444 01/22/2021

Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury.

(Pelisch N, Rosas Almanza J, Stehlik KE, Aperi BV, Kroner A.) eNeuro. 2021;8(2) PMID: 33632814 PMCID: PMC7986543 02/27/2021

Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models.

(Laliberte AM, Karadimas SK, Vidal PM, Satkunendrarajah K, Fehlings MG.) Brain Commun. 2021;3(1):fcaa234 PMID: 33604572 PMCID: PMC7878254 02/20/2021

Bilateral cervical contusion spinal cord injury: A mouse model to evaluate sensorimotor function.

(Reinhardt DR, Stehlik KE, Satkunendrarajah K, Kroner A.) Exp Neurol. 2020 Sep;331:113381 PMID: 32561411 SCOPUS ID: 2-s2.0-85086575731 06/21/2020

Sensory cortical control of movement.

(Karadimas SK, Satkunendrarajah K, Laliberte AM, Ringuette D, Weisspapir I, Li L, Gosgnach S, Fehlings MG.) Nat Neurosci. 2020 Jan;23(1):75-84 PMID: 31740813 SCOPUS ID: 2-s2.0-85075146992 11/20/2019

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2

(Williams JJ, Vazquez AL, Schwartz AB.) International IEEE/EMBS Conference on Neural Engineering, NER. 16 May 2019;2019-March:534-537 SCOPUS ID: 2-s2.0-85066753496 05/16/2019

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.

(Williams JJ, Watson AM, Vazquez AL, Schwartz AB.) Front Neurosci. 2019;13:759 PMID: 31417342 PMCID: PMC6684788 08/17/2019

Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface.

(Michelson NJ, Vazquez AL, Eles JR, Salatino JW, Purcell EK, Williams JJ, Cui XT, Kozai TDY.) J Neural Eng. 2018 Jun;15(3):033001 PMID: 29182149 PMCID: PMC5967409 SCOPUS ID: 2-s2.0-85047317370 11/29/2017

Spatial co-adaptation of cortical control columns in a micro-ECoG brain-computer interface.

(Rouse AG, Williams JJ, Wheeler JJ, Moran DW.) J Neural Eng. 2016 Oct;13(5):056018 PMID: 27651034 09/22/2016

Idle state classification using spiking activity and local field potentials in a brain computer interface.

(Williams JJ, Tien RN, Inoue Y, Schwartz AB.) Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:1572-1575 PMID: 28268628 SCOPUS ID: 2-s2.0-85009083903 03/09/2017

Differentiating closed-loop cortical intention from rest: building an asynchronous electrocorticographic BCI.

(Williams JJ, Rouse AG, Thongpang S, Williams JC, Moran DW.) J Neural Eng. 2013 Aug;10(4):046001 PMID: 23715295 SCOPUS ID: 2-s2.0-84883151862 05/30/2013