Microbiology& Immunology Faculty and Research
Faculty research spans a broad range of interests including viral and bacterial infection and pathogenesis, inflammation and immunology, enzymology and metabolism, molecular genetics, and signaling and gene expression. Our faculty address questions at the cellular and molecular level, using contemporary technology and approaches where more than 30 faculty serve as graduate student research mentors. Many graduates of our program conduct postdoctoral studies and then serve as faculty at academic medical centers, or go on to become scientists in research institutes, industry, and government.
Departmental bacteriologists study a variety of organisms and topics, which include the identification and characterization of the delivery, trafficking and function of bacterial toxins that target key cellular processes of the eukaryotic host. Faculty research interests also address intrinsic antibiotic resistance in Gram-positive bacteria such as E. faecalis where one major areas of study is a kinase/phosphatase system that mediates resistance to the cephalosporin family of antibiotics. Other faculty study host-pathogen interactions of spirochetes.
Departmental virologists study different research topics on members of the herpesvirus family. These topics include studies on the immune evasions encoded by human herpesvirus 6 and 7, host/ human cytomegalovirus interactions, using a combination of virology and mass spectrometry.
Departmental immunologists address various aspects of the immune system. These topics include the study of chemokines, which are chemotactic cytokines that can affect the homing of various cell types to different organs. This work focuses on how the expression of chemokines and chemokine receptors affects tumor progression and metastasis; pancreatic cancer and other high-risk malignancies are a particular focus.
Center for Immunology
The Center for Immunology Program consists of a highly collaborative and integrated group of scientists from the Medical College of Wisconsin, Blood Research Institute and Children’s Research Institute whose goal is to promote immunological education and research on campus at both the basic and clinical level. the Center for Immunology is composed of research laboratories focused on the immunological aspects of autoimmunity, infectious disease, allergy, immunodeficiency and cancer and is forging new links to physician colleagues at Froedtert Hospital and the Children’s Hospital of Wisconsin.