Microbiology & Immunology
Mycobacterium, Two-Component Systems, Lipid DropletsView Thomas C. Zahrt Bio
Project 1: Elucidate the function of PspA
The goal of this project is define the mechanism(s) by which PspA regulates lipid droplet homeostasis and non-replicating persistence in Mycobacterium.
Project 2: Sequestration of Mycobacterial proteins by lipid droplets
The goal of this project is to determine if lipid droplets regulate the transition of Mycobacterium into non-replicating persistence by sequestering key proteins normally involved in energy production, transcription and translation, and DNA compaction and cell wall synthesis.