Medical College of Wisconsin Cardiac Amyloid Program
About Cardiac Amyloidosis
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Comprehensive Treatment Options
There are several types of amyloidosis; the two most commonly affecting the heart are:
- AL Amyloidosis: amyloid fibrils are composed of immunoglobulin light chain proteins produced in the bone marrow and most commonly affect the heart, kidneys, skin, nerves, and liver.
- ATTR Amyloidosis: can be based on a genetic mutation in the transthyretin protein (variant or ATTRv) or acquired (wild type or ATTRwt).
- Hereditary (variant, ATTRv) transthyretin amyloidosis is an autosomal dominant, multi-organ, progressive, life-threatening disease caused by mutations in the gene encoding TTR production by the liver. The most common ATTRv mutation in the US is V122I. It affects 3-4% of African American population with variable penetrance.
- Wild-type ATTR (ATTRwt) amyloidosis is a slowly progressive disease, typically affecting patients over age 65. The disease typically is manifested as heart failure with preserved ejection fraction, atrial fibrillation, and neuropathy.
There is currently no cure for amyloidosis, but treatments are available which manage symptoms and limit the production of the amyloid protein with the goal to ultimately slow or stop the disease process and improve morbidity and mortality.
To transfer a patient or consult with a specialist (for physicians and staff only):
Call the Access Center at (414) 805-4700 or (877) 804-4700.
Nurses are available 24 hours a day, seven days a week.
Please call (414) 777-7700 to make an appointment in the Cardiovascular Medicine clinic.