Valve Disease Clinical Trials
We have three current trials: TAVR Unload, Early TAVR, and REPRISE IV.
TAVR Unload
The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate aortic stenosis (AS) compared with optimized heart failure therapy (OHFT).
Subinvestigator: Peter Mason, MD; Paul Pearson, MD; Josh Meskin, MD; Fasseas Panayotis, MD; Dhiraj Baruah, MD; Nunzio Gaglianello, MD; David Ishizawar, MD; Zachary Laste, MD
Status: Currently enrolling
Sub Category: Heart Valve Disease
Meet Our Team
Learn about our TAVR Unload Team

Panayotis Fasseas, MD, FACC
Associate Professor

Nunzio Gaglianello, MD
Associate Professor

David Ishizawar, MD
Assistant Professor

Peter Mason, MD, MPH, RPVI
Associate Professor

Joshua A. Meskin, MD, FACC
Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

Paul J. Pearson, MD, PhD
Professor and Chief, Cardiothoracic Surgery

Michael Salinger, MD, FACC, FSCAI
Professor
Early TAVR
To establish the safety and effectiveness of the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis
Subinvestigator: Michael Salinger, MD; Paul Pearson, MD; Joshua Meskin, MD; Panayotis Fasseas, MD; Dhiraj Baruah, MD; James Kleczka, MD; Zachary Laste, MD
Status: Currently enrolling
Sub Category: Heart Valve Disease
Meet Our Team
Learn about our Early TAVR Team

Panayotis Fasseas, MD, FACC
Associate Professor

James F. Kleczka, MD, FACC
Associate Professor

Peter Mason, MD, MPH, RPVI
Associate Professor

Joshua A. Meskin, MD, FACC
Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

Paul J. Pearson, MD, PhD
Professor and Chief, Cardiothoracic Surgery

Michael Salinger, MD, FACC, FSCAI
Professor
REPRISE IV
This is a prospective, multicenter single-arm study designed to evaluate the safety and effectiveness of the LOTUS Edge Valve System for TAVR in symptomatic subjects who have severe native aortic stenosis and are considered at intermediate risk for surgical valve replacement.
Subinvestigators: Peter Mason, MD; Paul Pearson, MD; Joshua Meskin, MD;
Status: Currently enrolling
Sub Category: Heart Valve Disease
Meet Our Team
Learn about our REPRISE IV Team

Peter Mason, MD, MPH, RPVI
Associate Professor

Joshua A. Meskin, MD, FACC
Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

Paul J. Pearson, MD, PhD
Professor and Chief, Cardiothoracic Surgery
