Valve Disease Clinical Trials
We have three current trials: TAVR Unload, Early TAVR.
TAVR Unload
View TAVR Unload information
The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate aortic stenosis (AS) compared with optimized heart failure therapy (OHFT).
Primary Investigator: Will be announced
Subinvestigator: Peter Mason, MD; Paul Pearson, MD; Josh Meskin, MD; Fasseas Panayotis, MD; Dhiraj Baruah, MD; Nunzio Gaglianello, MD; David Ishizawar, MD; Zachary Laste, MD
Subinvestigator: Peter Mason, MD; Paul Pearson, MD; Josh Meskin, MD; Fasseas Panayotis, MD; Dhiraj Baruah, MD; Nunzio Gaglianello, MD; David Ishizawar, MD; Zachary Laste, MD
Status: Currently enrolling
Sub Category: Heart Valve Disease
Meet Our Team
Learn about our TAVR Unload Team

Panayotis Fasseas, MD, FACC
Associate Professor

Nunzio A. Gaglianello, MD
Associate Professor

David Ishizawar, MD
Assistant Professor

Peter Mason, MD, MPH
Associate Professor

Joshua A. Meskin, MD, FACC
Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

Paul Joseph Pearson, MD, PhD
Chief, Professor
Early TAVR
View Early TAVR information
To establish the safety and effectiveness of the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis
Primary Investigator: Peter Mason, MD
Subinvestigator: Michael Salinger, MD; Paul Pearson, MD; Joshua Meskin, MD; Panayotis Fasseas, MD; Dhiraj Baruah, MD; James Kleczka, MD; Zachary Laste, MD
Subinvestigator: Michael Salinger, MD; Paul Pearson, MD; Joshua Meskin, MD; Panayotis Fasseas, MD; Dhiraj Baruah, MD; James Kleczka, MD; Zachary Laste, MD
Status: Currently enrolling
Sub Category: Heart Valve Disease
Meet Our Team
Learn about our Early TAVR Team

Panayotis Fasseas, MD, FACC
Associate Professor

James F. Kleczka, MD, FACC
Associate Professor

Peter Mason, MD, MPH
Associate Professor

Joshua A. Meskin, MD, FACC
Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

Paul Joseph Pearson, MD, PhD
Chief, Professor
Cardiovascular Clinical Trials
The Cardiovascular Research Service is currently conducting drug and/or device trials in the cardiac subspecialties listed. However, this does not limit what we may be working on tomorrow.
Please contact the Cardiovascular Trials program by calling (414) 955-7021 or at DOMCVClinTriStaff@mcw.edu.