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Valve Disease Clinical Trials

We have three current trials: TAVR Unload, Early TAVR. 

TAVR Unload

View TAVR Unload information

The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate aortic stenosis (AS) compared with optimized heart failure therapy (OHFT).

Primary Investigator: Will be announced
Subinvestigator: Peter Mason, MD; Paul Pearson, MD; Josh Meskin, MD; Fasseas Panayotis, MD; Dhiraj Baruah, MD; Nunzio Gaglianello, MD; David Ishizawar, MD; Zachary Laste, MD

Status: Currently enrolling
Sub Category: Heart Valve Disease

Meet Our Team

Learn about our TAVR Unload Team

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Panayotis Fasseas, MD, FACC

Associate Professor

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Nunzio A. Gaglianello, MD

Associate Professor

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David Ishizawar, MD

Assistant Professor

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Peter Mason, MD, MPH

Associate Professor

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Joshua A. Meskin, MD, FACC

Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

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Paul Joseph Pearson, MD, PhD

Chief, Professor

Early TAVR

View Early TAVR information

To establish the safety and effectiveness of the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis

Primary Investigator: Peter Mason, MD
Subinvestigator: Michael Salinger, MD; Paul Pearson, MD; Joshua Meskin, MD; Panayotis Fasseas, MD; Dhiraj Baruah, MD; James Kleczka, MD; Zachary Laste, MD

Status: Currently enrolling
Sub Category: Heart Valve Disease

Meet Our Team

Learn about our Early TAVR Team

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Panayotis Fasseas, MD, FACC

Associate Professor

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James F. Kleczka, MD, FACC

Associate Professor

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Peter Mason, MD, MPH

Associate Professor

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Joshua A. Meskin, MD, FACC

Vice Chair for Ambulatory Operations, Department of Medicine; Associate Professor, Division of Cardiovascular Medicine Medical College of Wisconsin; Director of Froedtert & MCW Echocardiographic Laboratories Froedtert & MCW Health Network

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Paul Joseph Pearson, MD, PhD

Chief, Professor

Cardiovascular Clinical Trials

The Cardiovascular Research Service is currently conducting drug and/or device trials in the cardiac subspecialties listed. However, this does not limit what we may be working on tomorrow.

Please contact the Cardiovascular Trials program by calling (414) 955-7021 or at DOMCVClinTriStaff@mcw.edu.