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Cardiovascular Medicine

Valve Disease Clinical Trials

We have three current trials: TAVR Unload, Early TAVR, and REPRISE IV. 

TAVR Unload

View TAVR Unload information

The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate aortic stenosis (AS) compared with optimized heart failure therapy (OHFT).

Primary Investigator: Michael Salinger, MD
Subinvestigator: Peter Mason, MD; Paul Pearson, MD; Josh Meskin, MD; Fasseas Panayotis, MD; Dhiraj Baruah, MD; Nunzio Gaglianello, MD; David Ishizawar, MD; Zachary Laste, MD

Status: Currently enrolling
Sub Category: Heart Valve Disease

Meet Our Team

Learn about our TAVR Unload Team

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Dhiraj Baruah, MD

Assistant Professor of Radiology

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Panayotis Fasseas, MD, FACC

Associate Professor

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Nunzio Gaglianello, MD

Assistant Professor; Director of the Cardiovascular Medicine Fellowship

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David Ishizawar, MD

Assistant Professor

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Zachary R. Laste, MD

Assistant Professor of Radiology

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Peter Mason, MD, MPH, RPVI

Associate Professor

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Joshua A. Meskin, MD, FACC

Associate Professor

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Paul J. Pearson, MD, PhD

Professor and Chief, Cardiothoracic Surgery

Early TAVR

View Early TAVR information

To establish the safety and effectiveness of the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis

Primary Investigator: Peter Mason, MD
Subinvestigator: Michael Salinger, MD; Paul Pearson, MD; Joshua Meskin, MD; Panayotis Fasseas, MD; Dhiraj Baruah, MD; James Kleczka, MD; Zachary Laste, MD

Status: Currently enrolling
Sub Category: Heart Valve Disease

Meet Our Team

Learn about our Early TAVR Team

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Dhiraj Baruah, MD

Assistant Professor of Radiology

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Panayotis Fasseas, MD, FACC

Associate Professor

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James F. Kleczka, MD, FACC

Associate Professor

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Zachary R. Laste, MD

Assistant Professor of Radiology

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Peter Mason, MD, MPH, RPVI

Associate Professor

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Joshua A. Meskin, MD, FACC

Associate Professor

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Paul J. Pearson, MD, PhD

Professor and Chief, Cardiothoracic Surgery

REPRISE IV

View REPRISE IV information

This is a prospective, multicenter single-arm study designed to evaluate the safety and effectiveness of the LOTUS Edge Valve System for TAVR in symptomatic subjects who have severe native aortic stenosis and are considered at intermediate risk for surgical valve replacement.

Primary Investigator: Michael Salinger, MD
Subinvestigators: Peter Mason, MD; Paul Pearson, MD; Joshua Meskin, MD; 

Status: Currently enrolling
Sub Category: Heart Valve Disease

Meet Our Team

Learn about our REPRISE IV Team

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Peter Mason, MD, MPH, RPVI

Associate Professor

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Joshua A. Meskin, MD, FACC

Associate Professor

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Paul J. Pearson, MD, PhD

Professor and Chief, Cardiothoracic Surgery

Cardiovascular Clinical Trials

The Cardiovascular Research Service is currently conducting drug and/or device trials in the cardiac subspecialties listed. However, this does not limit what we may be working on tomorrow.

Please contact the Cardiovascular Trials program by calling (414) 955-7021 or at DOMCVClinTriStaff@mcw.edu.